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Distinct contribution of the parietal and temporal cortex to manipulation and contextual knowledge of tool use

(2013) CORTEX. 49(8). p.2097-2105
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Abstract
Neuropsychological studies showed that manipulatory and semantic knowledge can be independently impaired in patients with upper-limb apraxia, leading to different tool use disorders. The present study aimed to dissociate the brain regions involved in judging the hand configuration or the context associated to tool use. We focussed on the left supramarginalis gyrus (SMG) and left middle temporal gyrus (MTG), whose activation, as evidenced by fMRI studies, suggests that they may play a critical role in tool use. The distinctive location of SMG in the dorsal visual stream led us to postulate that this parietal region could play a role in processing incoming information about tools to shape hand posture. In contrast, we hypothesized that MTG, because of its interconnections with several cortical areas involved in semantic memory, could contribute to retrieving semantic information necessary to create a contextual representation of tool use. To test these hypotheses, we used neuronavigated transcranial magnetic stimulation (TMS) to interfere transiently with the function of either left SMG or left MTG in healthy participants performing judgment tasks about either hand configuration or context of tool use. We found that SMG virtual lesions impaired hand configuration but not contextual judgments, whereas MTG lesions selectively interfered with judgments about the context of tool use while leaving hand configuration judgements unaffected. This double dissociation demonstrates that the ability to infer a context of use or a hand posture from tool perception relies on distinct processes, performed in the temporal and parietal regions. The present findings suggest that tool use disorders caused by SMG lesions will be characterized by difficulties in selecting the appropriate hand posture for tool use, whereas MTG lesions will yield difficulties in using tools in the appropriate context.
Keywords
CONCEPTUAL KNOWLEDGE, MANIPULATABLE OBJECTS, MAGNETIC STIMULATION, SELECTIVE IMPAIRMENT, IDEATIONAL APRAXIA, VENTRAL STREAM, NEURAL BASIS, REPRESENTATION, Action, SYSTEM, Upper-limb apraxia, Semantic memory, Transcranial magnetic stimulation, SEMANTIC MEMORY

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MLA
Andres, Michael, B Pelgrims, and E Olivier. “Distinct Contribution of the Parietal and Temporal Cortex to Manipulation and Contextual Knowledge of Tool Use.” CORTEX 49.8 (2013): 2097–2105. Print.
APA
Andres, M., Pelgrims, B., & Olivier, E. (2013). Distinct contribution of the parietal and temporal cortex to manipulation and contextual knowledge of tool use. CORTEX, 49(8), 2097–2105.
Chicago author-date
Andres, Michael, B Pelgrims, and E Olivier. 2013. “Distinct Contribution of the Parietal and Temporal Cortex to Manipulation and Contextual Knowledge of Tool Use.” Cortex 49 (8): 2097–2105.
Chicago author-date (all authors)
Andres, Michael, B Pelgrims, and E Olivier. 2013. “Distinct Contribution of the Parietal and Temporal Cortex to Manipulation and Contextual Knowledge of Tool Use.” Cortex 49 (8): 2097–2105.
Vancouver
1.
Andres M, Pelgrims B, Olivier E. Distinct contribution of the parietal and temporal cortex to manipulation and contextual knowledge of tool use. CORTEX. 2013;49(8):2097–105.
IEEE
[1]
M. Andres, B. Pelgrims, and E. Olivier, “Distinct contribution of the parietal and temporal cortex to manipulation and contextual knowledge of tool use,” CORTEX, vol. 49, no. 8, pp. 2097–2105, 2013.
@article{3089625,
  abstract     = {Neuropsychological studies showed that manipulatory and semantic knowledge can be independently impaired in patients with upper-limb apraxia, leading to different tool use disorders. The present study aimed to dissociate the brain regions involved in judging the hand configuration or the context associated to tool use. We focussed on the left supramarginalis gyrus (SMG) and left middle temporal gyrus (MTG), whose activation, as evidenced by fMRI studies, suggests that they may play a critical role in tool use. The distinctive location of SMG in the dorsal visual stream led us to postulate that this parietal region could play a role in processing incoming information about tools to shape hand posture. In contrast, we hypothesized that MTG, because of its interconnections with several cortical areas involved in semantic memory, could contribute to retrieving semantic information necessary to create a contextual representation of tool use. To test these hypotheses, we used neuronavigated transcranial magnetic stimulation (TMS) to interfere transiently with the function of either left SMG or left MTG in healthy participants performing judgment tasks about either hand configuration or context of tool use. We found that SMG virtual lesions impaired hand configuration but not contextual judgments, whereas MTG lesions selectively interfered with judgments about the context of tool use while leaving hand configuration judgements unaffected. This double dissociation demonstrates that the ability to infer a context of use or a hand posture from tool perception relies on distinct processes, performed in the temporal and parietal regions. The present findings suggest that tool use disorders caused by SMG lesions will be characterized by difficulties in selecting the appropriate hand posture for tool use, whereas MTG lesions will yield difficulties in using tools in the appropriate context.},
  author       = {Andres, Michael and Pelgrims, B and Olivier, E},
  issn         = {0010-9452},
  journal      = {CORTEX},
  keywords     = {CONCEPTUAL KNOWLEDGE,MANIPULATABLE OBJECTS,MAGNETIC STIMULATION,SELECTIVE IMPAIRMENT,IDEATIONAL APRAXIA,VENTRAL STREAM,NEURAL BASIS,REPRESENTATION,Action,SYSTEM,Upper-limb apraxia,Semantic memory,Transcranial magnetic stimulation,SEMANTIC MEMORY},
  language     = {eng},
  number       = {8},
  pages        = {2097--2105},
  title        = {Distinct contribution of the parietal and temporal cortex to manipulation and contextual knowledge of tool use},
  url          = {http://dx.doi.org/10.1016/j.cortex.2012.11.013},
  volume       = {49},
  year         = {2013},
}

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