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Frailty and sarcopenia: definitions and outcome parameters

(2012) OSTEOPOROSIS INTERNATIONAL. 23(7). p.1839-1848
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Abstract
An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis. Frailty and sarcopenia are linked, but distinct, correlates of musculoskeletal aging that have many causes, including age-related changes in body composition, inflammation, and hormonal imbalance. With the emergence of a number of exciting candidate therapies to retard the loss of muscle mass with aging, the derivation of a consensual definition of sarcopenia and physical frailty becomes an urgent priority. Although several consensual definitions have been proposed, these require clinical validation. An operational definition, which might provide a threshold for treatment/trial inclusion, should incorporate a loss of muscle mass as well as evidence of a decrease in muscle strength and/or physical activity. Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients.
Keywords
Frailty, Assessment, Outcome, Pathophysiology, Sarcopenia, Treatment, LIFE-STYLE INTERVENTIONS, HORMONE-BINDING GLOBULIN, SKELETAL-MUSCLE, BODY-COMPOSITION, HERTFORDSHIRE COHORT, ELDERLY-MEN, PHYSICAL-DISABILITY, MOBILITY LIMITATION, ANDROGEN LEVELS, GROWTH-HORMONE

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Citation

Please use this url to cite or link to this publication:

Chicago
Cooper, C, W Dere, W Evans, JA Kanis, R Rizzoli, AA Sayer, CC Sieber, et al. 2012. “Frailty and Sarcopenia: Definitions and Outcome Parameters.” Osteoporosis International 23 (7): 1839–1848.
APA
Cooper, C, Dere, W., Evans, W., Kanis, J., Rizzoli, R., Sayer, A., Sieber, C., et al. (2012). Frailty and sarcopenia: definitions and outcome parameters. OSTEOPOROSIS INTERNATIONAL, 23(7), 1839–1848.
Vancouver
1.
Cooper C, Dere W, Evans W, Kanis J, Rizzoli R, Sayer A, et al. Frailty and sarcopenia: definitions and outcome parameters. OSTEOPOROSIS INTERNATIONAL. 2012;23(7):1839–48.
MLA
Cooper, C, W Dere, W Evans, et al. “Frailty and Sarcopenia: Definitions and Outcome Parameters.” OSTEOPOROSIS INTERNATIONAL 23.7 (2012): 1839–1848. Print.
@article{3087683,
  abstract     = {An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis. Frailty and sarcopenia are linked, but distinct, correlates of musculoskeletal aging that have many causes, including age-related changes in body composition, inflammation, and hormonal imbalance. With the emergence of a number of exciting candidate therapies to retard the loss of muscle mass with aging, the derivation of a consensual definition of sarcopenia and physical frailty becomes an urgent priority. Although several consensual definitions have been proposed, these require clinical validation. An operational definition, which might provide a threshold for treatment/trial inclusion, should incorporate a loss of muscle mass as well as evidence of a decrease in muscle strength and/or physical activity. Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients.},
  author       = {Cooper, C and Dere, W and Evans, W and Kanis, JA and Rizzoli, R and Sayer, AA and Sieber, CC and Kaufman, Jean and Abellan van Kan, G and Boonen, S and Adachi, J and Mitlak, B and Tsouderos, Y and Rolland, Y and Reginster, J-YL},
  issn         = {0937-941X},
  journal      = {OSTEOPOROSIS INTERNATIONAL},
  keywords     = {Frailty,Assessment,Outcome,Pathophysiology,Sarcopenia,Treatment,LIFE-STYLE INTERVENTIONS,HORMONE-BINDING GLOBULIN,SKELETAL-MUSCLE,BODY-COMPOSITION,HERTFORDSHIRE COHORT,ELDERLY-MEN,PHYSICAL-DISABILITY,MOBILITY LIMITATION,ANDROGEN LEVELS,GROWTH-HORMONE},
  language     = {eng},
  number       = {7},
  pages        = {1839--1848},
  title        = {Frailty and sarcopenia: definitions and outcome parameters},
  url          = {http://dx.doi.org/10.1007/s00198-012-1913-1},
  volume       = {23},
  year         = {2012},
}

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