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Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome

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Abstract
To allow early detection and prevention of metabolic disorders, circulating levels of adipokines involved in insulin sensitivity were compared with the hyperinsulinemic-euglycemic clamp. Twenty non-obese normo-glycaemic men (age 32.1 +/- 6 years) underwent a clamp procedure. Levels of leptin, adiponectin, resistin, visfatin, omentin and chemerin levels were determined in fasting blood samples. Pearson correlation coefficients between the M-value for insulin sensitivity and fasting levels of chemerin (r = -0.63, P = 0.003) and leptin (r = -0.54, P = 0.013) performed better than conventional surrogate measures of insulin sensitivity (HOMA-IR: r = -0.45, P = 0.048; Quicki: r = 0.36, P = 0.12). However, only the relation between M-value(LBM) and chemerin remained significant when adjusting for BMI and fasting insulin levels (r = -0.559, P = 0.016). In conclusion, fasting levels of chemerin might be used as biomarker to identify insulin resistance in healthy men without typical characteristics of metabolic disorders.
Keywords
HUMANS, METFORMIN, EXPRESSION, RESISTANCE, OBESITY, GLUCOSE, prevention, detection, insulin sensitivity, Chemerin, BETA-CELL FUNCTION, screening

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Chicago
Ouwens, D Margriet, Marlies Bekaert, Bruno Lapauw, Yves Van Nieuwenhove, Stefan Lehr, Sonja Hartwig, Patrick Calders, et al. 2012. “Chemerin as Biomarker for Insulin Sensitivity in Males Without Typical Characteristics of Metabolic Syndrome.” Archives of Physiology and Biochemistry 118 (3): 135–138.
APA
Ouwens, D. M., Bekaert, M., Lapauw, B., Van Nieuwenhove, Y., Lehr, S., Hartwig, S., Calders, P., et al. (2012). Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 118(3), 135–138.
Vancouver
1.
Ouwens DM, Bekaert M, Lapauw B, Van Nieuwenhove Y, Lehr S, Hartwig S, et al. Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY. 2012;118(3):135–8.
MLA
Ouwens, D Margriet, Marlies Bekaert, Bruno Lapauw, et al. “Chemerin as Biomarker for Insulin Sensitivity in Males Without Typical Characteristics of Metabolic Syndrome.” ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY 118.3 (2012): 135–138. Print.
@article{3087592,
  abstract     = {To allow early detection and prevention of metabolic disorders, circulating levels of adipokines involved in insulin sensitivity were compared with the hyperinsulinemic-euglycemic clamp. Twenty non-obese normo-glycaemic men (age 32.1 +/- 6 years) underwent a clamp procedure. Levels of leptin, adiponectin, resistin, visfatin, omentin and chemerin levels were determined in fasting blood samples. Pearson correlation coefficients between the M-value for insulin sensitivity and fasting levels of chemerin (r = -0.63, P = 0.003) and leptin (r = -0.54, P = 0.013) performed better than conventional surrogate measures of insulin sensitivity (HOMA-IR: r = -0.45, P = 0.048; Quicki: r = 0.36, P = 0.12). However, only the relation between M-value(LBM) and chemerin remained significant when adjusting for BMI and fasting insulin levels (r = -0.559, P = 0.016). In conclusion, fasting levels of chemerin might be used as biomarker to identify insulin resistance in healthy men without typical characteristics of metabolic disorders.},
  author       = {Ouwens, D Margriet and Bekaert, Marlies and Lapauw, Bruno and Van Nieuwenhove, Yves and Lehr, Stefan and Hartwig, Sonja and Calders, Patrick and Kaufman, Jean and Sell, Henrike and Eckel, Juergen and Ruige, Johannes},
  issn         = {1381-3455},
  journal      = {ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY},
  language     = {eng},
  number       = {3},
  pages        = {135--138},
  title        = {Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome},
  url          = {http://dx.doi.org/10.3109/13813455.2012.654800},
  volume       = {118},
  year         = {2012},
}

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