
Bone mass, bone geometry, and body composition in female-to-male transsexual persons after long-term cross-sex hormonal therapy
- Author
- Eva Van Caenegem, Katrien Wierckx, Youri Taes (UGent) , David Dedecker (UGent) , Fleur Van de Peer (UGent) , Kaatje Toye (UGent) , Jean Kaufman (UGent) and Guy T'Sjoen (UGent)
- Organization
- Abstract
- Context: Female-to-male transsexual persons (transsexual men) undergo extreme hormonal changes due to ovariectomy and testosterone substitution, allowing studies on sex steroid effects on bone geometry and physiology in the adult. Objective: The objective of the study was to examine the effects of cross-gender sex steroid exposure on volumetric bone parameters in transsexual men. Design: This was a cross-sectional study. Setting: Participants were recruited from the Center for Sexology and Gender Problems at the Ghent University Hospital (Ghent, Belgium). Participants: Fifty transsexual men after sex reassignment surgery with 50 age-matched control women and an additional 16 transsexual men before testosterone substitution and sex reassignment surgery with 16 control women participated in the study. Main Outcome Measures: The main outcome measures were areal and volumetric bone parameters using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, body composition (dual-energy X-ray absorptiometry), sex steroids, markers of bone turnover and grip strength. Results: Before hormonal treatment, transsexual men had similar body composition and bone geometry as female controls. The transsexual men on long-term testosterone therapy, however, demonstrated a higher lean body mass and muscle mass and a greater grip strength as well as a lower body and subcutaneous fat mass and a larger waist and smaller hip circumference compared with female controls (all P < 0.001). We observed a larger radial cortical bone size (P < 0.001) and lower cortical volumetric bone mineral density at the radius and tibia (P < 0.05) in transsexual men on testosterone therapy. Conclusions: Transsexual men on testosterone substitution therapy present with a different body composition with more muscle mass and strength and less fat mass as well as an altered bone geometry with larger bones compared with female controls.
- Keywords
- QUANTITATIVE COMPUTED-TOMOGRAPHY, MINERAL DENSITY, FAT DISTRIBUTION, POSTMENOPAUSAL WOMEN, PHYSICAL-ACTIVITY, TENNIS PLAYERS, SIZE, AGE, TESTOSTERONE, MEN
Downloads
-
(...).pdf
- full text
- |
- UGent only
- |
- |
- 166.86 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-3087563
- MLA
- Van Caenegem, Eva, Katrien Wierckx, Youri Taes, et al. “Bone Mass, Bone Geometry, and Body Composition in Female-to-male Transsexual Persons After Long-term Cross-sex Hormonal Therapy.” JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 97.7 (2012): 2503–2511. Print.
- APA
- Van Caenegem, E., Wierckx, K., Taes, Y., Dedecker, D., Van de Peer, F., Toye, K., Kaufman, J., et al. (2012). Bone mass, bone geometry, and body composition in female-to-male transsexual persons after long-term cross-sex hormonal therapy. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 97(7), 2503–2511.
- Chicago author-date
- Van Caenegem, Eva, Katrien Wierckx, Youri Taes, David Dedecker, Fleur Van de Peer, Kaatje Toye, Jean Kaufman, and Guy T’Sjoen. 2012. “Bone Mass, Bone Geometry, and Body Composition in Female-to-male Transsexual Persons After Long-term Cross-sex Hormonal Therapy.” Journal of Clinical Endocrinology & Metabolism 97 (7): 2503–2511.
- Chicago author-date (all authors)
- Van Caenegem, Eva, Katrien Wierckx, Youri Taes, David Dedecker, Fleur Van de Peer, Kaatje Toye, Jean Kaufman, and Guy T’Sjoen. 2012. “Bone Mass, Bone Geometry, and Body Composition in Female-to-male Transsexual Persons After Long-term Cross-sex Hormonal Therapy.” Journal of Clinical Endocrinology & Metabolism 97 (7): 2503–2511.
- Vancouver
- 1.Van Caenegem E, Wierckx K, Taes Y, Dedecker D, Van de Peer F, Toye K, et al. Bone mass, bone geometry, and body composition in female-to-male transsexual persons after long-term cross-sex hormonal therapy. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2012;97(7):2503–11.
- IEEE
- [1]E. Van Caenegem et al., “Bone mass, bone geometry, and body composition in female-to-male transsexual persons after long-term cross-sex hormonal therapy,” JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 97, no. 7, pp. 2503–2511, 2012.
@article{3087563, abstract = {Context: Female-to-male transsexual persons (transsexual men) undergo extreme hormonal changes due to ovariectomy and testosterone substitution, allowing studies on sex steroid effects on bone geometry and physiology in the adult. Objective: The objective of the study was to examine the effects of cross-gender sex steroid exposure on volumetric bone parameters in transsexual men. Design: This was a cross-sectional study. Setting: Participants were recruited from the Center for Sexology and Gender Problems at the Ghent University Hospital (Ghent, Belgium). Participants: Fifty transsexual men after sex reassignment surgery with 50 age-matched control women and an additional 16 transsexual men before testosterone substitution and sex reassignment surgery with 16 control women participated in the study. Main Outcome Measures: The main outcome measures were areal and volumetric bone parameters using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography, body composition (dual-energy X-ray absorptiometry), sex steroids, markers of bone turnover and grip strength. Results: Before hormonal treatment, transsexual men had similar body composition and bone geometry as female controls. The transsexual men on long-term testosterone therapy, however, demonstrated a higher lean body mass and muscle mass and a greater grip strength as well as a lower body and subcutaneous fat mass and a larger waist and smaller hip circumference compared with female controls (all P < 0.001). We observed a larger radial cortical bone size (P < 0.001) and lower cortical volumetric bone mineral density at the radius and tibia (P < 0.05) in transsexual men on testosterone therapy. Conclusions: Transsexual men on testosterone substitution therapy present with a different body composition with more muscle mass and strength and less fat mass as well as an altered bone geometry with larger bones compared with female controls.}, author = {Van Caenegem, Eva and Wierckx, Katrien and Taes, Youri and Dedecker, David and Van de Peer, Fleur and Toye, Kaatje and Kaufman, Jean and T'Sjoen, Guy}, issn = {0021-972X}, journal = {JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM}, keywords = {QUANTITATIVE COMPUTED-TOMOGRAPHY,MINERAL DENSITY,FAT DISTRIBUTION,POSTMENOPAUSAL WOMEN,PHYSICAL-ACTIVITY,TENNIS PLAYERS,SIZE,AGE,TESTOSTERONE,MEN}, language = {eng}, number = {7}, pages = {2503--2511}, title = {Bone mass, bone geometry, and body composition in female-to-male transsexual persons after long-term cross-sex hormonal therapy}, url = {http://dx.doi.org/10.1210/jc.2012-1187}, volume = {97}, year = {2012}, }
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: