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Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females

Margot Berings, Charline Wehlou, An Verrijken, Ellen Deschepper UGent, Ilse Mertens, Jean Kaufman UGent, Luc F Van Gaal, D Margriet Ouwens and Johannes Ruige (2012) PLOS ONE. 7(9).
abstract
Context: Lipotoxicity is a risk factor for developing obesity-related metabolic complications, including non-alcoholic fatty liver disease, type 2 diabetes (DM2), cardiovascular disease and stroke. Yet, the mechanisms underlying the development of lipotoxicity itself remain poorly understood. Here, we investigated whether glucose intolerance aggravates lipotoxicity by evaluating the association between triglyceride (TG) concentrations and glucose tolerance status in a cross-sectional study on obese Caucasian women at risk for DM2. Methods: 913 obese females unknown to have diabetes were recruited (mean age: 41.2 +/- SD 12.3; median BMI: 36.2, IQR 32.9-40.2). Visceral (VAT) and subcutaneous abdominal adipose tissue volumes were quantified with computed tomography. Glucose, insulin, and triglyceride concentrations were determined in fasting state and following a 75 gram oral glucose tolerance test. Results: Based on fasting and 2 h post-load glucose levels, 27% of the women had impaired glucose tolerance (IGT), and 8% had newly diagnosed DM2. Fasting TG concentrations were similar between the IGT- and DM2-groups, and increased as compared to women with normal glucose tolerance (NGT). Even when adjusting for age, hip circumference and VAT, fasting TG concentrations remained elevated as compared to NGT. Mixed modelling analysis of post-load responses showed that TG concentrations declined more slowly in the DM2-group as compared to IGT and NGT. However, when adjusting for VAT the difference in decline between the glucose tolerance groups disappeared. Conclusions: Glucose intolerance associates with elevated fasting TG concentrations in obese Caucasian women. We propose that glucose intolerance and increased VAT reduce lipid disposal mechanisms and may accelerate lipotoxicity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INSULIN-RESISTANCE, CORONARY-HEART-DISEASE, DIABETES-MELLITUS, YOUNG MEN, RISK, FAT, HEALTH, TIME, HIP
journal title
PLOS ONE
PLoS One
volume
7
issue
9
article number
e45145
pages
5 pages
Web of Science type
Article
Web of Science id
000309973900027
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
3.73 (2012)
JCR rank
7/56 (2012)
JCR quartile
1 (2012)
ISSN
1932-6203
DOI
10.1371/journal.pone.0045145
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
3087551
handle
http://hdl.handle.net/1854/LU-3087551
date created
2013-01-10 11:53:52
date last changed
2016-12-21 15:41:22
@article{3087551,
  abstract     = {Context: Lipotoxicity is a risk factor for developing obesity-related metabolic complications, including non-alcoholic fatty liver disease, type 2 diabetes (DM2), cardiovascular disease and stroke. Yet, the mechanisms underlying the development of lipotoxicity itself remain poorly understood. Here, we investigated whether glucose intolerance aggravates lipotoxicity by evaluating the association between triglyceride (TG) concentrations and glucose tolerance status in a cross-sectional study on obese Caucasian women at risk for DM2. 
Methods: 913 obese females unknown to have diabetes were recruited (mean age: 41.2 +/- SD 12.3; median BMI: 36.2, IQR 32.9-40.2). Visceral (VAT) and subcutaneous abdominal adipose tissue volumes were quantified with computed tomography. Glucose, insulin, and triglyceride concentrations were determined in fasting state and following a 75 gram oral glucose tolerance test. 
Results: Based on fasting and 2 h post-load glucose levels, 27\% of the women had impaired glucose tolerance (IGT), and 8\% had newly diagnosed DM2. Fasting TG concentrations were similar between the IGT- and DM2-groups, and increased as compared to women with normal glucose tolerance (NGT). Even when adjusting for age, hip circumference and VAT, fasting TG concentrations remained elevated as compared to NGT. Mixed modelling analysis of post-load responses showed that TG concentrations declined more slowly in the DM2-group as compared to IGT and NGT. However, when adjusting for VAT the difference in decline between the glucose tolerance groups disappeared. 
Conclusions: Glucose intolerance associates with elevated fasting TG concentrations in obese Caucasian women. We propose that glucose intolerance and increased VAT reduce lipid disposal mechanisms and may accelerate lipotoxicity.},
  articleno    = {e45145},
  author       = {Berings, Margot and Wehlou, Charline and Verrijken, An and Deschepper, Ellen and Mertens, Ilse and Kaufman, Jean and Van Gaal, Luc F and Ouwens, D Margriet and Ruige, Johannes},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {INSULIN-RESISTANCE,CORONARY-HEART-DISEASE,DIABETES-MELLITUS,YOUNG MEN,RISK,FAT,HEALTH,TIME,HIP},
  language     = {eng},
  number       = {9},
  pages        = {5},
  title        = {Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females},
  url          = {http://dx.doi.org/10.1371/journal.pone.0045145},
  volume       = {7},
  year         = {2012},
}

Chicago
Berings, Margot, Charline Wehlou, An Verrijken, Ellen Deschepper, Ilse Mertens, Jean Kaufman, Luc F Van Gaal, D Margriet Ouwens, and Johannes Ruige. 2012. “Glucose Intolerance and the Amount of Visceral Adipose Tissue Contribute to an Increase in Circulating Triglyceride Concentrations in Caucasian Obese Females.” Plos One 7 (9).
APA
Berings, M., Wehlou, C., Verrijken, A., Deschepper, E., Mertens, I., Kaufman, J., Van Gaal, L. F., et al. (2012). Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females. PLOS ONE, 7(9).
Vancouver
1.
Berings M, Wehlou C, Verrijken A, Deschepper E, Mertens I, Kaufman J, et al. Glucose intolerance and the amount of visceral adipose tissue contribute to an increase in circulating triglyceride concentrations in Caucasian obese females. PLOS ONE. 2012;7(9).
MLA
Berings, Margot, Charline Wehlou, An Verrijken, et al. “Glucose Intolerance and the Amount of Visceral Adipose Tissue Contribute to an Increase in Circulating Triglyceride Concentrations in Caucasian Obese Females.” PLOS ONE 7.9 (2012): n. pag. Print.