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Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model

Liesbet Van Praet, Filip Van den Bosch (UGent) , Peggy Jacques (UGent) , Philippe Carron (UGent) , Lennart Jans (UGent) , Roos Colman (UGent) , Elien Glorieus (UGent) , Harald Peeters (UGent) , Herman Mielants (UGent) , Martine De Vos (UGent) , et al.
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Abstract
Objective : To assess the rates and explore predictors of microscopic gut inflammation in a cohort of patients with axial and peripheral spondyloarthritis (SpA). Methods : Ileocolonoscopy was performed in 65 patients with axial and peripheral SpA from the Gent Inflammatory Arthritis and spoNdylitis cohorT. Histopathological analysis and scoring were performed by an experienced pathologist. Results : Overall, 46.2% of the patients with SpA showed microscopic gut inflammation. In axial SpA, the following parameters were independently associated with gut involvement: male sex (OR = 8.9, p = 0.035); high disease activity measured by the Bath Ankylosing Spondylitis Disease Activity Index (OR = 2.05, p = 0.032); restricted spinal mobility measured by the Bath Ankylosing Spondylitis Metrology Index (OR = 1.94, p = 0.009); and younger age (OR = 0.85, p = 0.013). No clear association was found for human leucocyte antigen-B27 status, presence of peripheral arthritis, enthesitis, uveitis, psoriasis, intake of non-steroidal anti-inflammatory drugs and family history of SpA. The prevalence of gut inflammation in non-radiographic axial SpA and ankylosing spondylitis was comparable. Conclusions : The prevalence of microscopic gut inflammation in SpA remains unaltered over time. Younger age (shorter symptom duration), progressive disease, male sex and higher disease activity are independently associated with microscopic gut inflammation in axial SpA.
Keywords
DISEASE, LESIONS, ARTHRITIS, EVOLUTION, BOWEL INFLAMMATION, HISTOLOGY, SAFETY

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MLA
Van Praet, Liesbet, et al. “Microscopic Gut Inflammation in Axial Spondyloarthritis: A Multiparametric Predictive Model.” ANNALS OF THE RHEUMATIC DISEASES, vol. 72, no. 3, 2013, pp. 414–17.
APA
Van Praet, L., Van den Bosch, F., Jacques, P., Carron, P., Jans, L., Colman, R., … Elewaut, D. (2013). Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model. ANNALS OF THE RHEUMATIC DISEASES, 72(3), 414–417.
Chicago author-date
Van Praet, Liesbet, Filip Van den Bosch, Peggy Jacques, Philippe Carron, Lennart Jans, Roos Colman, Elien Glorieus, et al. 2013. “Microscopic Gut Inflammation in Axial Spondyloarthritis: A Multiparametric Predictive Model.” ANNALS OF THE RHEUMATIC DISEASES 72 (3): 414–17.
Chicago author-date (all authors)
Van Praet, Liesbet, Filip Van den Bosch, Peggy Jacques, Philippe Carron, Lennart Jans, Roos Colman, Elien Glorieus, Harald Peeters, Herman Mielants, Martine De Vos, Claude Cuvelier, and Dirk Elewaut. 2013. “Microscopic Gut Inflammation in Axial Spondyloarthritis: A Multiparametric Predictive Model.” ANNALS OF THE RHEUMATIC DISEASES 72 (3): 414–417.
Vancouver
1.
Van Praet L, Van den Bosch F, Jacques P, Carron P, Jans L, Colman R, et al. Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model. ANNALS OF THE RHEUMATIC DISEASES. 2013;72(3):414–7.
IEEE
[1]
L. Van Praet et al., “Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model,” ANNALS OF THE RHEUMATIC DISEASES, vol. 72, no. 3, pp. 414–417, 2013.
@article{3087212,
  abstract     = {Objective : To assess the rates and explore predictors of microscopic gut inflammation in a cohort of patients with axial and peripheral spondyloarthritis (SpA). 
Methods : Ileocolonoscopy was performed in 65 patients with axial and peripheral SpA from the Gent Inflammatory Arthritis and spoNdylitis cohorT. Histopathological analysis and scoring were performed by an experienced pathologist. 
Results : Overall, 46.2% of the patients with SpA showed microscopic gut inflammation. In axial SpA, the following parameters were independently associated with gut involvement: male sex (OR = 8.9, p = 0.035); high disease activity measured by the Bath Ankylosing Spondylitis Disease Activity Index (OR = 2.05, p = 0.032); restricted spinal mobility measured by the Bath Ankylosing Spondylitis Metrology Index (OR = 1.94, p = 0.009); and younger age (OR = 0.85, p = 0.013). No clear association was found for human leucocyte antigen-B27 status, presence of peripheral arthritis, enthesitis, uveitis, psoriasis, intake of non-steroidal anti-inflammatory drugs and family history of SpA. The prevalence of gut inflammation in non-radiographic axial SpA and ankylosing spondylitis was comparable. 
Conclusions : The prevalence of microscopic gut inflammation in SpA remains unaltered over time. Younger age (shorter symptom duration), progressive disease, male sex and higher disease activity are independently associated with microscopic gut inflammation in axial SpA.},
  author       = {Van Praet, Liesbet and Van den Bosch, Filip and Jacques, Peggy and Carron, Philippe and Jans, Lennart and Colman, Roos and Glorieus, Elien and Peeters, Harald and Mielants, Herman and De Vos, Martine and Cuvelier, Claude and Elewaut, Dirk},
  issn         = {0003-4967},
  journal      = {ANNALS OF THE RHEUMATIC DISEASES},
  keywords     = {DISEASE,LESIONS,ARTHRITIS,EVOLUTION,BOWEL INFLAMMATION,HISTOLOGY,SAFETY},
  language     = {eng},
  number       = {3},
  pages        = {414--417},
  title        = {Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2012-202135},
  volume       = {72},
  year         = {2013},
}

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