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Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model

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Abstract
In the present work, we report the characterization of a Cryptosporidium parvum strain isolated from a patient who nearly drowned in the Deule River (Lille, France) after being discharged from the hospital where he had undergone allogeneic stem cell transplantation. After being rescued and readmitted to the hospital, he developed fulminant cryptosporidiosis. The strain isolated from the patient's stools was identified as C. parvum II2A15G2R1 (subtype linked to zoonotic exposure) and inoculated into SCID mice. In this host, this virulent C. parvum isolate induced not only severe infection but also invasive gastrointestinal and biliary adenocarcinoma. The observation of adenocarcinomas that progressed through all layers of the digestive tract to the subserosa and spread via blood vessels confirmed the invasive nature of the neoplastic process. These results indicate for the first time that a human-derived C. parvum isolate is able to induce digestive cancer. This study is of special interest considering the exposure of a large number of humans and animals to this waterborne protozoan, which is highly tumorigenic when inoculated in a rodent model.
Keywords
MICE, HYPER-IGM, INFECTION, IMMUNODEFICIENCY, EPIDEMIOLOGY, LIVER

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Chicago
Certad, Gabriela, Sadia Benamrouz, Karine Guyot, Anthony Mouray, Thierry Chassat, Nicolas Flament, Laurence Delhaes, et al. 2012. “Fulminant Cryptosporidiosis After Near-drowning: a Human Cryptosporidium Parvum Strain Implicated in Invasive Gastrointestinal Adenocarcinoma and Cholangiocarcinoma in an Experimental Model.” Applied and Environmental Microbiology 78 (6): 1746–1751.
APA
Certad, Gabriela, Benamrouz, S., Guyot, K., Mouray, A., Chassat, T., Flament, N., Delhaes, L., et al. (2012). Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(6), 1746–1751.
Vancouver
1.
Certad G, Benamrouz S, Guyot K, Mouray A, Chassat T, Flament N, et al. Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model. APPLIED AND ENVIRONMENTAL MICROBIOLOGY. 2012;78(6):1746–51.
MLA
Certad, Gabriela, Sadia Benamrouz, Karine Guyot, et al. “Fulminant Cryptosporidiosis After Near-drowning: a Human Cryptosporidium Parvum Strain Implicated in Invasive Gastrointestinal Adenocarcinoma and Cholangiocarcinoma in an Experimental Model.” APPLIED AND ENVIRONMENTAL MICROBIOLOGY 78.6 (2012): 1746–1751. Print.
@article{3087017,
  abstract     = {In the present work, we report the characterization of a Cryptosporidium parvum strain isolated from a patient who nearly drowned in the Deule River (Lille, France) after being discharged from the hospital where he had undergone allogeneic stem cell transplantation. After being rescued and readmitted to the hospital, he developed fulminant cryptosporidiosis. The strain isolated from the patient's stools was identified as C. parvum II2A15G2R1 (subtype linked to zoonotic exposure) and inoculated into SCID mice. In this host, this virulent C. parvum isolate induced not only severe infection but also invasive gastrointestinal and biliary adenocarcinoma. The observation of adenocarcinomas that progressed through all layers of the digestive tract to the subserosa and spread via blood vessels confirmed the invasive nature of the neoplastic process. These results indicate for the first time that a human-derived C. parvum isolate is able to induce digestive cancer. This study is of special interest considering the exposure of a large number of humans and animals to this waterborne protozoan, which is highly tumorigenic when inoculated in a rodent model.},
  author       = {Certad, Gabriela and Benamrouz, Sadia and Guyot, Karine and Mouray, Anthony and Chassat, Thierry and Flament, Nicolas and Delhaes, Laurence and Coiteux, Valerie and Delaire, Baptiste and Praet, Marleen and Cuvelier, Claude and Gosset, Peirre and Dei-Cas, Eduardo and Creusy, Colette},
  issn         = {0099-2240},
  journal      = {APPLIED AND ENVIRONMENTAL MICROBIOLOGY},
  keywords     = {MICE,HYPER-IGM,INFECTION,IMMUNODEFICIENCY,EPIDEMIOLOGY,LIVER},
  language     = {eng},
  number       = {6},
  pages        = {1746--1751},
  title        = {Fulminant cryptosporidiosis after near-drowning: a human Cryptosporidium parvum strain implicated in invasive gastrointestinal adenocarcinoma and cholangiocarcinoma in an experimental model},
  url          = {http://dx.doi.org/10.1128/AEM.06457-11},
  volume       = {78},
  year         = {2012},
}

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