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Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis

(2012) MUSCLE & NERVE. 46(6). p.917-925
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Abstract
Introduction: In Duchenne muscular dystrophy (DMD), the infiltration of skeletal muscle by immune cells aggravates disease, yet the precise mechanisms behind these inflammatory responses remain poorly understood. Chemotactic cytokines, or chemokines, are considered essential recruiters of inflammatory cells to the tissues. Methods: We assayed chemokine and chemokine receptor expression in DMD muscle biopsies (n = 9, average age 7 years) using immunohistochemistry, immunofluorescence, and in situ hybridization. Results: CXCL1, CXCL2, CXCL3, CXCL8, and CXCL11, absent from normal muscle fibers, were induced in DMD myofibers. CXCL11, CXCL12, and the ligandreceptor couple CCL2CCR2 were upregulated on the blood vessel endothelium of DMD patients. CD68+ macrophages expressed high levels of CXCL8, CCL2, and CCL5. Conclusions: Our data suggest a possible beneficial role for CXCR1/2/4 ligands in managing muscle fiber damage control and tissue regeneration. Upregulation of endothelial chemokine receptors and CXCL8, CCL2, and CCL5 expression by cytotoxic macrophages may regulate myofiber necrosis.
Keywords
chemokine receptors, chemokines, Duchenne muscular dystrophy, muscle regeneration, myositis, SKELETAL-MUSCLE INJURY, CC CLASS CHEMOKINES, CXC CHEMOKINES, EXPRESSION, MACROPHAGE, CELLS, PATHOPHYSIOLOGY, REGENERATION, INVOLVEMENT, MYOGENESIS

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MLA
De Paepe, Boel, Kim Creus, Jean-Jacques Martin, et al. “Upregulation of Chemokines and Their Receptors in Duchenne Muscular Dystrophy: Potential for Attenuation of Myofiber Necrosis.” MUSCLE & NERVE 46.6 (2012): 917–925. Print.
APA
De Paepe, Boel, Creus, K., Martin, J.-J., & De Bleecker, J. (2012). Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis. MUSCLE & NERVE, 46(6), 917–925.
Chicago author-date
De Paepe, Boel, Kim Creus, Jean-Jacques Martin, and Jan De Bleecker. 2012. “Upregulation of Chemokines and Their Receptors in Duchenne Muscular Dystrophy: Potential for Attenuation of Myofiber Necrosis.” Muscle & Nerve 46 (6): 917–925.
Chicago author-date (all authors)
De Paepe, Boel, Kim Creus, Jean-Jacques Martin, and Jan De Bleecker. 2012. “Upregulation of Chemokines and Their Receptors in Duchenne Muscular Dystrophy: Potential for Attenuation of Myofiber Necrosis.” Muscle & Nerve 46 (6): 917–925.
Vancouver
1.
De Paepe B, Creus K, Martin J-J, De Bleecker J. Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis. MUSCLE & NERVE. 2012;46(6):917–25.
IEEE
[1]
B. De Paepe, K. Creus, J.-J. Martin, and J. De Bleecker, “Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis,” MUSCLE & NERVE, vol. 46, no. 6, pp. 917–925, 2012.
@article{3079204,
  abstract     = {Introduction: In Duchenne muscular dystrophy (DMD), the infiltration of skeletal muscle by immune cells aggravates disease, yet the precise mechanisms behind these inflammatory responses remain poorly understood. Chemotactic cytokines, or chemokines, are considered essential recruiters of inflammatory cells to the tissues.
Methods: We assayed chemokine and chemokine receptor expression in DMD muscle biopsies (n = 9, average age 7 years) using immunohistochemistry, immunofluorescence, and in situ hybridization.
Results: CXCL1, CXCL2, CXCL3, CXCL8, and CXCL11, absent from normal muscle fibers, were induced in DMD myofibers. CXCL11, CXCL12, and the ligandreceptor couple CCL2CCR2 were upregulated on the blood vessel endothelium of DMD patients. CD68+ macrophages expressed high levels of CXCL8, CCL2, and CCL5.
Conclusions: Our data suggest a possible beneficial role for CXCR1/2/4 ligands in managing muscle fiber damage control and tissue regeneration. Upregulation of endothelial chemokine receptors and CXCL8, CCL2, and CCL5 expression by cytotoxic macrophages may regulate myofiber necrosis.},
  author       = {De Paepe, Boel and Creus, Kim and Martin, Jean-Jacques and De Bleecker, Jan},
  issn         = {0148-639X},
  journal      = {MUSCLE & NERVE},
  keywords     = {chemokine receptors,chemokines,Duchenne muscular dystrophy,muscle regeneration,myositis,SKELETAL-MUSCLE INJURY,CC CLASS CHEMOKINES,CXC CHEMOKINES,EXPRESSION,MACROPHAGE,CELLS,PATHOPHYSIOLOGY,REGENERATION,INVOLVEMENT,MYOGENESIS},
  language     = {eng},
  number       = {6},
  pages        = {917--925},
  title        = {Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis},
  url          = {http://dx.doi.org/10.1002/mus.23481},
  volume       = {46},
  year         = {2012},
}

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