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The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling

Peter Vandenabeele (UGent) and Mathieu Bertrand (UGent)
(2012) NATURE REVIEWS IMMUNOLOGY. 12(12). p.833-844
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Abstract
An inflammatory response is initiated when innate immune pattern-recognition receptors (PRRs) expressed by different cell types detect constituents of invading microorganisms and endogenous intracellular molecules released by dying cells. The intracellular cascades activated by PRRs induce the expression and maturation of inflammatory molecules that coordinate the removal of the infectious agents and of the infected or damaged cells. In this Review, we discuss the findings implicating members of the inhibitor of apoptosis protein (IAP) family in the ubiquitylation-dependent regulation of PRR signalling. Understanding the role of IAPs in innate immunity may open new therapeutic perspectives for the treatment of PRR-dependent inflammatory diseases.
Keywords
INNATE IMMUNE-RESPONSES, ALPHA-DEPENDENT APOPTOSIS, NEGATIVE BACTERIAL-INFECTION, NF-KAPPA-B, DROSOPHILA IMD PATHWAY, NOD-LIKE RECEPTORS, TNF-ALPHA, ANTIVIRAL RESPONSE, CELL-SURVIVAL, ANTIBACTERIAL DEFENSE

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Citation

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MLA
Vandenabeele, Peter, and Mathieu Bertrand. “The Role of the IAP E3 Ubiquitin Ligases in Regulating Pattern-recognition Receptor Signalling.” NATURE REVIEWS IMMUNOLOGY 12.12 (2012): 833–844. Print.
APA
Vandenabeele, P., & Bertrand, M. (2012). The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling. NATURE REVIEWS IMMUNOLOGY, 12(12), 833–844.
Chicago author-date
Vandenabeele, Peter, and Mathieu Bertrand. 2012. “The Role of the IAP E3 Ubiquitin Ligases in Regulating Pattern-recognition Receptor Signalling.” Nature Reviews Immunology 12 (12): 833–844.
Chicago author-date (all authors)
Vandenabeele, Peter, and Mathieu Bertrand. 2012. “The Role of the IAP E3 Ubiquitin Ligases in Regulating Pattern-recognition Receptor Signalling.” Nature Reviews Immunology 12 (12): 833–844.
Vancouver
1.
Vandenabeele P, Bertrand M. The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling. NATURE REVIEWS IMMUNOLOGY. 2012;12(12):833–44.
IEEE
[1]
P. Vandenabeele and M. Bertrand, “The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling,” NATURE REVIEWS IMMUNOLOGY, vol. 12, no. 12, pp. 833–844, 2012.
@article{3077252,
  abstract     = {An inflammatory response is initiated when innate immune pattern-recognition receptors (PRRs) expressed by different cell types detect constituents of invading microorganisms and endogenous intracellular molecules released by dying cells. The intracellular cascades activated by PRRs induce the expression and maturation of inflammatory molecules that coordinate the removal of the infectious agents and of the infected or damaged cells. In this Review, we discuss the findings implicating members of the inhibitor of apoptosis protein (IAP) family in the ubiquitylation-dependent regulation of PRR signalling. Understanding the role of IAPs in innate immunity may open new therapeutic perspectives for the treatment of PRR-dependent inflammatory diseases.},
  author       = {Vandenabeele, Peter and Bertrand, Mathieu},
  issn         = {1474-1733},
  journal      = {NATURE REVIEWS IMMUNOLOGY},
  keywords     = {INNATE IMMUNE-RESPONSES,ALPHA-DEPENDENT APOPTOSIS,NEGATIVE BACTERIAL-INFECTION,NF-KAPPA-B,DROSOPHILA IMD PATHWAY,NOD-LIKE RECEPTORS,TNF-ALPHA,ANTIVIRAL RESPONSE,CELL-SURVIVAL,ANTIBACTERIAL DEFENSE},
  language     = {eng},
  number       = {12},
  pages        = {833--844},
  title        = {The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling},
  url          = {http://dx.doi.org/10.1038/nri3325},
  volume       = {12},
  year         = {2012},
}

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