Advanced search
1 file | 527.68 KB

Previous healthcare exposure is the main antecedent for methicillin-resistant Staphylococcus aureus carriage on hospital admission in Belgium

Author
Organization
Abstract
This study aimed to estimate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) carriage upon hospital admission and to study the molecular epidemiology of MRSA in order to assess the proportion of Panton-Valentine leukocidin (PVL)-positive community-associated (CA) and livestock-associated (LA) MRSA strains. Epidemiological data on MRSA carriage upon hospital admission (2006-2009) were collected in a compulsory, continuous, national MRSA surveillance in Belgian acute-care hospitals. Additionally, 328 MRSA strains in 2005 and 314 strains in 2008 were collected in a separate, multicenter microbiological survey. Spa-typing, SCCmec-typing and MLST were performed; toxin genes were detected by PCR. The overall prevalence of MRSA carriage upon hospital admission was 8.9 cases/1,000 admissions between 2006 and 2009. Of MRSA carriers, 37.5% had a known MRSA history, 39.4% had stayed in a care facility, 12.2% reported no contact with healthcare. Over 90% of MRSA belonged to five healthcare-associated clones. Of these, MRSA spa-CC038-ST45-IV was in decline, mainly in favor of spa-CC008-ST8-IV. MRSA spa-CC002-ST5-IV, spa-CC002-ST5-II and spa-CC032-ST22-IV remained relatively stable. The proportion of PVL-positive CA-MRSA and LA-MRSA ST398 was below 2% of all MRSA. The extra-hospital MRSA reservoir in Belgium mainly consists of persons with previous healthcare exposure. PVL-positive CA-MRSA and LA-MRSA strains remained infrequent among hospitalized patients.
Keywords
NATIONAL-SURVEY, EPIDEMIOLOGY, CLONES, GENES, MRSA, SURVEILLANCE, EMERGENCE, STRAINS, ST398, PCR

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 527.68 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Vandendriessche, Stien, M Hallin, B Catry, B Jans, A Deplano, C Nonhoff, S Roisin, R De Mendonça, MJ Struelens, and O Denis. 2012. “Previous Healthcare Exposure Is the Main Antecedent for Methicillin-resistant Staphylococcus Aureus Carriage on Hospital Admission in Belgium.” European Journal of Clinical Microbiology & Infectious Diseases 31 (9): 2283–2292.
APA
Vandendriessche, Stien, Hallin, M., Catry, B., Jans, B., Deplano, A., Nonhoff, C., Roisin, S., et al. (2012). Previous healthcare exposure is the main antecedent for methicillin-resistant Staphylococcus aureus carriage on hospital admission in Belgium. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 31(9), 2283–2292.
Vancouver
1.
Vandendriessche S, Hallin M, Catry B, Jans B, Deplano A, Nonhoff C, et al. Previous healthcare exposure is the main antecedent for methicillin-resistant Staphylococcus aureus carriage on hospital admission in Belgium. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES. 2012;31(9):2283–92.
MLA
Vandendriessche, Stien, M Hallin, B Catry, et al. “Previous Healthcare Exposure Is the Main Antecedent for Methicillin-resistant Staphylococcus Aureus Carriage on Hospital Admission in Belgium.” EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 31.9 (2012): 2283–2292. Print.
@article{3074417,
  abstract     = {This study aimed to estimate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) carriage upon hospital admission and to study the molecular epidemiology of MRSA in order to assess the proportion of Panton-Valentine leukocidin (PVL)-positive community-associated (CA) and livestock-associated (LA) MRSA strains. Epidemiological data on MRSA carriage upon hospital admission (2006-2009) were collected in a compulsory, continuous, national MRSA surveillance in Belgian acute-care hospitals. Additionally, 328 MRSA strains in 2005 and 314 strains in 2008 were collected in a separate, multicenter microbiological survey. Spa-typing, SCCmec-typing and MLST were performed; toxin genes were detected by PCR. The overall prevalence of MRSA carriage upon hospital admission was 8.9 cases/1,000 admissions between 2006 and 2009. Of MRSA carriers, 37.5\% had a known MRSA history, 39.4\% had stayed in a care facility, 12.2\% reported no contact with healthcare. Over 90\% of MRSA belonged to five healthcare-associated clones. Of these, MRSA spa-CC038-ST45-IV was in decline, mainly in favor of spa-CC008-ST8-IV. MRSA spa-CC002-ST5-IV, spa-CC002-ST5-II and spa-CC032-ST22-IV remained relatively stable. The proportion of PVL-positive CA-MRSA and LA-MRSA ST398 was below 2\% of all MRSA. The extra-hospital MRSA reservoir in Belgium mainly consists of persons with previous healthcare exposure. PVL-positive CA-MRSA and LA-MRSA strains remained infrequent among hospitalized patients.},
  author       = {Vandendriessche, Stien and Hallin, M and Catry, B and Jans, B and Deplano, A and Nonhoff, C and Roisin, S and De Mendon\c{c}a, R and Struelens, MJ and Denis, O},
  issn         = {0934-9723},
  journal      = {EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY \& INFECTIOUS DISEASES},
  language     = {eng},
  number       = {9},
  pages        = {2283--2292},
  title        = {Previous healthcare exposure is the main antecedent for methicillin-resistant Staphylococcus aureus carriage on hospital admission in Belgium},
  url          = {http://dx.doi.org/10.1007/s10096-012-1567-0},
  volume       = {31},
  year         = {2012},
}

Altmetric
View in Altmetric
Web of Science
Times cited: