
Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?
- Author
- Huub Van Kuringen (UGent) , Joke Lenoir, Els Adriaens (UGent) , Johan Bender, Bruno De Geest (UGent) and Richard Hoogenboom (UGent)
- Organization
- Abstract
- The hydrolysis of PEtOx is studied to evaluate the potential toxicity of partially hydrolyzed polymers that might interfere with its increasing popularity for biomedical applications. The hydrolysis of PEtOx is studied in the presence of digestive enzymes (gastric and intestinal) and at 5.8?M hydrochloric acid as a function of temperature (57, 73, 90, and 100?degrees C). It is found that PEtOx undergoes negligible hydrolysis at 37?degrees C and that thermal and solution properties are not altered when up to 10% of the polymer backbone is hydrolyzed. Mucosal irritation and cytotoxicity is also absent up to 10% hydrolysis levels. In conclusion, PEtOx will not decompose at physiological conditions, and partial hydrolysis will not limit its biomedical applications.
- Keywords
- biomaterials, biocompatibility, hydrolysis, poly(2-oxazoline)s, stability, DRUG-DELIVERY, LINEAR POLY(ETHYLENIMINE), POLY(2-OXAZOLINE)S, POLYMER, ALTERNATIVES, COPOLYMERS, POLY(2-ALKYL-2-OXAZOLINE)S, 2-METHYL-2-OXAZOLINE, POLYETHYLENIMINE, BIODISTRIBUTION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-3072354
- MLA
- Van Kuringen, Huub, et al. “Partial Hydrolysis of Poly(2-Ethyl-2-Oxazoline) and Potential Implications for Biomedical Applications?” MACROMOLECULAR BIOSCIENCE, vol. 12, no. 8, 2012, pp. 1114–23, doi:10.1002/mabi.201200080.
- APA
- Van Kuringen, H., Lenoir, J., Adriaens, E., Bender, J., De Geest, B., & Hoogenboom, R. (2012). Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications? MACROMOLECULAR BIOSCIENCE, 12(8), 1114–1123. https://doi.org/10.1002/mabi.201200080
- Chicago author-date
- Van Kuringen, Huub, Joke Lenoir, Els Adriaens, Johan Bender, Bruno De Geest, and Richard Hoogenboom. 2012. “Partial Hydrolysis of Poly(2-Ethyl-2-Oxazoline) and Potential Implications for Biomedical Applications?” MACROMOLECULAR BIOSCIENCE 12 (8): 1114–23. https://doi.org/10.1002/mabi.201200080.
- Chicago author-date (all authors)
- Van Kuringen, Huub, Joke Lenoir, Els Adriaens, Johan Bender, Bruno De Geest, and Richard Hoogenboom. 2012. “Partial Hydrolysis of Poly(2-Ethyl-2-Oxazoline) and Potential Implications for Biomedical Applications?” MACROMOLECULAR BIOSCIENCE 12 (8): 1114–1123. doi:10.1002/mabi.201200080.
- Vancouver
- 1.Van Kuringen H, Lenoir J, Adriaens E, Bender J, De Geest B, Hoogenboom R. Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications? MACROMOLECULAR BIOSCIENCE. 2012;12(8):1114–23.
- IEEE
- [1]H. Van Kuringen, J. Lenoir, E. Adriaens, J. Bender, B. De Geest, and R. Hoogenboom, “Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?,” MACROMOLECULAR BIOSCIENCE, vol. 12, no. 8, pp. 1114–1123, 2012.
@article{3072354, abstract = {{The hydrolysis of PEtOx is studied to evaluate the potential toxicity of partially hydrolyzed polymers that might interfere with its increasing popularity for biomedical applications. The hydrolysis of PEtOx is studied in the presence of digestive enzymes (gastric and intestinal) and at 5.8?M hydrochloric acid as a function of temperature (57, 73, 90, and 100?degrees C). It is found that PEtOx undergoes negligible hydrolysis at 37?degrees C and that thermal and solution properties are not altered when up to 10% of the polymer backbone is hydrolyzed. Mucosal irritation and cytotoxicity is also absent up to 10% hydrolysis levels. In conclusion, PEtOx will not decompose at physiological conditions, and partial hydrolysis will not limit its biomedical applications.}}, author = {{Van Kuringen, Huub and Lenoir, Joke and Adriaens, Els and Bender, Johan and De Geest, Bruno and Hoogenboom, Richard}}, issn = {{1616-5187}}, journal = {{MACROMOLECULAR BIOSCIENCE}}, keywords = {{biomaterials,biocompatibility,hydrolysis,poly(2-oxazoline)s,stability,DRUG-DELIVERY,LINEAR POLY(ETHYLENIMINE),POLY(2-OXAZOLINE)S,POLYMER,ALTERNATIVES,COPOLYMERS,POLY(2-ALKYL-2-OXAZOLINE)S,2-METHYL-2-OXAZOLINE,POLYETHYLENIMINE,BIODISTRIBUTION}}, language = {{eng}}, number = {{8}}, pages = {{1114--1123}}, title = {{Partial hydrolysis of poly(2-ethyl-2-oxazoline) and potential implications for biomedical applications?}}, url = {{http://doi.org/10.1002/mabi.201200080}}, volume = {{12}}, year = {{2012}}, }
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