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Measurement of activity produced by low energy proton beam in metals using off-line PET imaging

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Abstract
In this work, we investigate PET imaging with Ga-68 and Ga-66 after proton irradiation on a natural zinc foil. The nuclides Ga-68 and Ga-66 are ideally suited for off-line PET monitoring of proton radiotherapy due to their beta-decay half-lives of 67.71(9) minutes and 9.49(3) hours, respectively, and suitable beta end-point energy. The purpose of this work is to explore the feasibility of PET monitoring in hadrontherapy treatments, and to study how the amount of activity and the positron range affect the PET image reconstruction. Profiting from the low energy reaction threshold for production via (p, n) reactions, both Ga-68 and Ga-66 gallium isotopes have been produced by activation on a natural zinc target by a proton pencil beam. In this way, it is possible to create detailed patterns, such as the Derenzo-inspired one employed here. The proton beam was produced by the 5 MV tandetron accelerator at CMAM in Madrid. The energy of this beam (up to 10 MeV) is similar to the residual energy of the protons used for therapy at the distal edge of their path. The activated target was imaged in an ARGUS small animal PET/CT scanner and reconstructed with a fully 3D iterative algorithm, with and without positron range corrections

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Chicago
Corzo, PMG, J Cal-Gonzalez, E Picado, Samuel Espana Palomares, JL Herraiz, E Herranz, E Vicente, et al. 2011. “Measurement of Activity Produced by Low Energy Proton Beam in Metals Using Off-line PET Imaging.” In IEEE Nuclear Science Symposium Conference Record, 3514–3517. New York, NY, USA: IEEE.
APA
Corzo, P., Cal-Gonzalez, J., Picado, E., Espana Palomares, S., Herraiz, J., Herranz, E., Vicente, E., et al. (2011). Measurement of activity produced by low energy proton beam in metals using off-line PET imaging. IEEE Nuclear Science Symposium Conference Record (pp. 3514–3517). Presented at the 2011 IEEE Nuclear Science symposium and Medical Imaging Conference (NSS/MIC 2011) ; 18th International workshop on Room-Temperature Semiconductor X-Ray and Gamma-Ray Detectors, New York, NY, USA: IEEE.
Vancouver
1.
Corzo P, Cal-Gonzalez J, Picado E, Espana Palomares S, Herraiz J, Herranz E, et al. Measurement of activity produced by low energy proton beam in metals using off-line PET imaging. IEEE Nuclear Science Symposium Conference Record. New York, NY, USA: IEEE; 2011. p. 3514–7.
MLA
Corzo, PMG et al. “Measurement of Activity Produced by Low Energy Proton Beam in Metals Using Off-line PET Imaging.” IEEE Nuclear Science Symposium Conference Record. New York, NY, USA: IEEE, 2011. 3514–3517. Print.
@inproceedings{3071607,
  abstract     = {In this work, we investigate PET imaging with Ga-68 and Ga-66 after proton irradiation on a natural zinc foil. The nuclides Ga-68 and Ga-66 are ideally suited for off-line PET monitoring of proton radiotherapy due to their beta-decay half-lives of 67.71(9) minutes and 9.49(3) hours, respectively, and suitable beta end-point energy. The purpose of this work is to explore the feasibility of PET monitoring in hadrontherapy treatments, and to study how the amount of activity and the positron range affect the PET image reconstruction. Profiting from the low energy reaction threshold for production via (p, n) reactions, both Ga-68 and Ga-66 gallium isotopes have been produced by activation on a natural zinc target by a proton pencil beam. In this way, it is possible to create detailed patterns, such as the Derenzo-inspired one employed here. The proton beam was produced by the 5 MV tandetron accelerator at CMAM in Madrid. The energy of this beam (up to 10 MeV) is similar to the residual energy of the protons used for therapy at the distal edge of their path. The activated target was imaged in an ARGUS small animal PET/CT scanner and reconstructed with a fully 3D iterative algorithm, with and without positron range corrections},
  author       = {Corzo, PMG and Cal-Gonzalez, J and Picado, E and Espana Palomares, Samuel and Herraiz, JL and Herranz, E and Vicente, E and Udias, JM and Vaquero, JJ and Mu{\~n}oz-Martin, A and Fraile, LM},
  booktitle    = {IEEE Nuclear Science Symposium Conference Record},
  isbn         = {9781467301183},
  issn         = {1082-3654},
  language     = {eng},
  location     = {Valencia, Spain},
  pages        = {3514--3517},
  publisher    = {IEEE},
  title        = {Measurement of activity produced by low energy proton beam in metals using off-line PET imaging},
  url          = {http://dx.doi.org/10.1109/NSSMIC.2011.6152646},
  year         = {2011},
}

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