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In vivo evaluation of a novel implant coating agent: laminin-1

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Abstract
Purpose: The aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo. Materials and Methods: Turned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1. Results: After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone. Conclusions: Within the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.
Keywords
titanium, implants, biochemical coating, laminin -1, OXIDIZED TITANIUM IMPLANTS, PERI-IMPLANTITIS, SPONTANEOUS PROGRESSION, FOLLOW-UP, SURFACE CHARACTERISTICS, BONE, DOGS, OSTEOPROGENITORS, ATTACHMENT, FIXATION

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MLA
Bougas, Kostas, et al. “In Vivo Evaluation of a Novel Implant Coating Agent: Laminin-1.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, vol. 16, no. 5, 2014, pp. 728–35, doi:10.1111/cid.12037.
APA
Bougas, K., Jimbo, R., Vandeweghe, S., Tovar, N., Baldassarri, M., Alenezi, A., … Wennerberg, A. (2014). In vivo evaluation of a novel implant coating agent: laminin-1. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, 16(5), 728–735. https://doi.org/10.1111/cid.12037
Chicago author-date
Bougas, Kostas, Ryo Jimbo, Stefan Vandeweghe, Nick Tovar, Marta Baldassarri, Ali Alenezi, Malvin Janal, Paulo Coelho, and Ann Wennerberg. 2014. “In Vivo Evaluation of a Novel Implant Coating Agent: Laminin-1.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH 16 (5): 728–35. https://doi.org/10.1111/cid.12037.
Chicago author-date (all authors)
Bougas, Kostas, Ryo Jimbo, Stefan Vandeweghe, Nick Tovar, Marta Baldassarri, Ali Alenezi, Malvin Janal, Paulo Coelho, and Ann Wennerberg. 2014. “In Vivo Evaluation of a Novel Implant Coating Agent: Laminin-1.” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH 16 (5): 728–735. doi:10.1111/cid.12037.
Vancouver
1.
Bougas K, Jimbo R, Vandeweghe S, Tovar N, Baldassarri M, Alenezi A, et al. In vivo evaluation of a novel implant coating agent: laminin-1. CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH. 2014;16(5):728–35.
IEEE
[1]
K. Bougas et al., “In vivo evaluation of a novel implant coating agent: laminin-1,” CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH, vol. 16, no. 5, pp. 728–735, 2014.
@article{3071559,
  abstract     = {{Purpose: The aim of this study was to assess the effect of implant coating with laminin-1 on the early stages of osseointegration in vivo. 
Materials and Methods: Turned titanium implants were coated with the osteoprogenitor-stimulating protein, laminin-1 (TL). Their osteogenic performance was assessed with removal torque, histomorphometry, and nanoindentation in a rabbit model after 2 and 4 weeks. The performance of the test implants was compared with turned control implants (T), alkali- and heat-treated implants (AH), and AH implants coated with laminin-1. 
Results: After 2 weeks, TL demonstrated significantly higher removal torque as compared with T and equivalent to AH. Bone area was significantly higher for the test surface after 4 weeks, while no significant changes were detected on the micromechanical properties of the surrounding bone. 
Conclusions: Within the limitations of this study, our results suggest a great potential for laminin-1 as a coating agent. A turned implant surface coated with laminin-1 could enhance osseointegration comparable with a bioactive implant surface while keeping the surface smooth.}},
  author       = {{Bougas, Kostas and Jimbo, Ryo and Vandeweghe, Stefan and Tovar, Nick and Baldassarri, Marta and Alenezi, Ali and Janal, Malvin and Coelho, Paulo and Wennerberg, Ann}},
  issn         = {{1523-0899}},
  journal      = {{CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH}},
  keywords     = {{titanium,implants,biochemical coating,laminin -1,OXIDIZED TITANIUM IMPLANTS,PERI-IMPLANTITIS,SPONTANEOUS PROGRESSION,FOLLOW-UP,SURFACE CHARACTERISTICS,BONE,DOGS,OSTEOPROGENITORS,ATTACHMENT,FIXATION}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{728--735}},
  title        = {{In vivo evaluation of a novel implant coating agent: laminin-1}},
  url          = {{http://doi.org/10.1111/cid.12037}},
  volume       = {{16}},
  year         = {{2014}},
}

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