Nano hydroxyapatite-coated implants improve bone nanomechanical properties
- Author
- Ryo Jimbo, Paulo Coelho, Matthew Bryington, M Baldassarri, Nick Tovar, F Currie, Mariko Hayashi, MN Janal, M Andersson, D Ono, Stefan Vandeweghe (UGent) and Ann Wennerberg
- Organization
- Abstract
- Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acidetched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.
- Keywords
- MODULUS, TOPOGRAPHY, DOGS, TITANIUM, TISSUE, SURFACES, MECHANICAL-PROPERTIES, MINERAL-CONTENT, dental implants, osseointegration, calcium phosphate, nanostructures, histology, biomechanics
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-3071523
- MLA
- Jimbo, Ryo, et al. “Nano Hydroxyapatite-Coated Implants Improve Bone Nanomechanical Properties.” JOURNAL OF DENTAL RESEARCH, vol. 91, no. 12, 2012, pp. 1172–77, doi:10.1177/0022034512463240.
- APA
- Jimbo, R., Coelho, P., Bryington, M., Baldassarri, M., Tovar, N., Currie, F., … Wennerberg, A. (2012). Nano hydroxyapatite-coated implants improve bone nanomechanical properties. JOURNAL OF DENTAL RESEARCH, 91(12), 1172–1177. https://doi.org/10.1177/0022034512463240
- Chicago author-date
- Jimbo, Ryo, Paulo Coelho, Matthew Bryington, M Baldassarri, Nick Tovar, F Currie, Mariko Hayashi, et al. 2012. “Nano Hydroxyapatite-Coated Implants Improve Bone Nanomechanical Properties.” JOURNAL OF DENTAL RESEARCH 91 (12): 1172–77. https://doi.org/10.1177/0022034512463240.
- Chicago author-date (all authors)
- Jimbo, Ryo, Paulo Coelho, Matthew Bryington, M Baldassarri, Nick Tovar, F Currie, Mariko Hayashi, MN Janal, M Andersson, D Ono, Stefan Vandeweghe, and Ann Wennerberg. 2012. “Nano Hydroxyapatite-Coated Implants Improve Bone Nanomechanical Properties.” JOURNAL OF DENTAL RESEARCH 91 (12): 1172–1177. doi:10.1177/0022034512463240.
- Vancouver
- 1.Jimbo R, Coelho P, Bryington M, Baldassarri M, Tovar N, Currie F, et al. Nano hydroxyapatite-coated implants improve bone nanomechanical properties. JOURNAL OF DENTAL RESEARCH. 2012;91(12):1172–7.
- IEEE
- [1]R. Jimbo et al., “Nano hydroxyapatite-coated implants improve bone nanomechanical properties,” JOURNAL OF DENTAL RESEARCH, vol. 91, no. 12, pp. 1172–1177, 2012.
@article{3071523, abstract = {{Nanostructure modification of dental implants has long been sought as a means to improve osseointegration through enhanced biomimicry of host structures. Several methods have been proposed and demonstrated for creating nanotopographic features; here we describe a nanoscale hydroxyapatite (HA)-coated implant surface and hypothesize that it will hasten osseointegration and improve its quality relative to that of non-coated implants. Twenty threaded titanium alloy implants, half prepared with a stable HA nanoparticle surface and half grit-blasted, acidetched, and heat-treated (HT), were inserted into rabbit femurs. Pre-operatively, the implants were morphologically and topographically characterized. After 3 weeks of healing, the samples were retrieved for histomorphometry. The nanomechanical properties of the surrounding bone were evaluated by nanoindentation. While both implants revealed similar bone-to-implant contact, the nanoindentation demonstrated that the tissue quality was significantly enhanced around the HA-coated implants, validating the postulated hypothesis.}}, author = {{Jimbo, Ryo and Coelho, Paulo and Bryington, Matthew and Baldassarri, M and Tovar, Nick and Currie, F and Hayashi, Mariko and Janal, MN and Andersson, M and Ono, D and Vandeweghe, Stefan and Wennerberg, Ann}}, issn = {{0022-0345}}, journal = {{JOURNAL OF DENTAL RESEARCH}}, keywords = {{MODULUS,TOPOGRAPHY,DOGS,TITANIUM,TISSUE,SURFACES,MECHANICAL-PROPERTIES,MINERAL-CONTENT,dental implants,osseointegration,calcium phosphate,nanostructures,histology,biomechanics}}, language = {{eng}}, number = {{12}}, pages = {{1172--1177}}, title = {{Nano hydroxyapatite-coated implants improve bone nanomechanical properties}}, url = {{http://doi.org/10.1177/0022034512463240}}, volume = {{91}}, year = {{2012}}, }
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