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Clozapine directly relaxes bovine retinal arteries

Koen Boussery UGent, Stijn Lambrecht UGent, Christophe Delaey and Johan Van de Voorde UGent (2005) CURRENT EYE RESEARCH. 30(2). p.139-146
abstract
Purpose: It was suggested that clozapine might be helpful in the development of new antiglaucoma agents, as it combines lowering the intraocular pressure after topical instillation with vasodilation. This study aimed to evaluate and characterize the vasodilatory effect of clozapine in isolated bovine retinal arteries ( BRAs). Methods: Retinal arteries were isolated from bovine eyes and mounted in the organ bath of a small vessel myograph. Results: Cumulative addition of clozapine ( 1 nM to 10 mu M) caused a concentration- dependent relaxation of the BRAs. Removal of the endothelium, inhibition of nitric oxide synthase and of soluble guanylyl cyclase reduced the clozapine response, whereas cyclooxygenase inhibition had no influence. A Ca2+ channel activator, a 5- hydroxytryptamine receptor antagonist, and an adenosine receptor antagonist failed in affecting the clozapine- induced relaxations. Conclusions: Clozapine relaxes bovine retinal arteries. Endothelium- derived NO seems to be involved, whereas prostanoids, calcium entry blockade, 5- HT7 receptor stimulation, and adenosine receptor stimulation do not.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
glaucoma, clozapine, retinal vasculature, vasodilation, VASCULAR SMOOTH-MUSCLE, INDUCED RELAXATION, 5-HT(7) RECEPTORS, GUANYLYL CYCLASE, ACETYLCHOLINE, TONE, ENDOTHELIUM, INHIBITION, RESPONSES, DELIVERY
journal title
CURRENT EYE RESEARCH
Curr. Eye Res.
volume
30
issue
2
pages
139 - 146
Web of Science type
Article
Web of Science id
000228182000007
JCR category
OPHTHALMOLOGY
JCR impact factor
1.116 (2005)
JCR rank
27/44 (2005)
JCR quartile
3 (2005)
ISSN
0271-3683
DOI
10.1080/02713680490904377
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
307094
handle
http://hdl.handle.net/1854/LU-307094
date created
2005-05-20 09:27:00
date last changed
2016-12-19 15:43:06
@article{307094,
  abstract     = {Purpose: It was suggested that clozapine might be helpful in the development of new antiglaucoma agents, as it combines lowering the intraocular pressure after topical instillation with vasodilation. This study aimed to evaluate and characterize the vasodilatory effect of clozapine in isolated bovine retinal arteries ( BRAs). Methods: Retinal arteries were isolated from bovine eyes and mounted in the organ bath of a small vessel myograph. Results: Cumulative addition of clozapine ( 1 nM to 10 mu M) caused a concentration- dependent relaxation of the BRAs. Removal of the endothelium, inhibition of nitric oxide synthase and of soluble guanylyl cyclase reduced the clozapine response, whereas cyclooxygenase inhibition had no influence. A Ca2+ channel activator, a 5- hydroxytryptamine receptor antagonist, and an adenosine receptor antagonist failed in affecting the clozapine- induced relaxations. Conclusions: Clozapine relaxes bovine retinal arteries. Endothelium- derived NO seems to be involved, whereas prostanoids, calcium entry blockade, 5- HT7 receptor stimulation, and adenosine receptor stimulation do not.},
  author       = {Boussery, Koen and Lambrecht, Stijn and Delaey, Christophe and Van de Voorde, Johan},
  issn         = {0271-3683},
  journal      = {CURRENT EYE RESEARCH},
  keyword      = {glaucoma,clozapine,retinal vasculature,vasodilation,VASCULAR SMOOTH-MUSCLE,INDUCED RELAXATION,5-HT(7) RECEPTORS,GUANYLYL CYCLASE,ACETYLCHOLINE,TONE,ENDOTHELIUM,INHIBITION,RESPONSES,DELIVERY},
  language     = {eng},
  number       = {2},
  pages        = {139--146},
  title        = {Clozapine directly relaxes bovine retinal arteries},
  url          = {http://dx.doi.org/10.1080/02713680490904377},
  volume       = {30},
  year         = {2005},
}

Chicago
Boussery, Koen, Stijn Lambrecht, Christophe Delaey, and Johan Van de Voorde. 2005. “Clozapine Directly Relaxes Bovine Retinal Arteries.” Current Eye Research 30 (2): 139–146.
APA
Boussery, Koen, Lambrecht, S., Delaey, C., & Van de Voorde, J. (2005). Clozapine directly relaxes bovine retinal arteries. CURRENT EYE RESEARCH, 30(2), 139–146.
Vancouver
1.
Boussery K, Lambrecht S, Delaey C, Van de Voorde J. Clozapine directly relaxes bovine retinal arteries. CURRENT EYE RESEARCH. 2005;30(2):139–46.
MLA
Boussery, Koen, Stijn Lambrecht, Christophe Delaey, et al. “Clozapine Directly Relaxes Bovine Retinal Arteries.” CURRENT EYE RESEARCH 30.2 (2005): 139–146. Print.