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Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study

Lies Lahousse UGent, Quirijn JA van den Bouwhuijsen, Daan W Loth, Guy Joos UGent, Albert Hofman, Jacqueline CM Witteman, Aad van der Lugt, Guy Brusselle UGent and Bruno H Stricker (2013) AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 187(1). p.58-64
abstract
Rationale: Chronic obstructive pulmonary disease (COPD) is an independent risk factor for ischemic stroke and the risk increases with severity of airflow limitation. Even though vulnerable carotid artery plaque components, such as intraplaque hemorrhage and lipid core, place persons at high risk for ischemic events, the plaque composition in COPD patients has never been explored. Objectives: To investigate the prevalence of carotid wall thickening, the different carotid artery plaque components, and their relations with severity of airflow limitation in elderly patients with COPD. Methods: This cross-sectional analysis was part of the Rotterdam Study, a prospective population-based cohort study performed in subjects aged 55 years and older. Diagnosis of COPD was confirmed by spirometry. Participants with carotid wall intima-media thickness (IMT) ≥ 2.5 mm on ultrasonography underwent high-resolution magnetic resonance imaging (MRI) for characterization of carotid plaques. Data were analyzed using logistic regression. Main Results: COPD cases (n = 253) had a twofold increased risk (OR 2.0, 95%CI 1.44-2.85, p<0.0001) of presentation with carotid wall thickening on ultrasonography compared to controls with a normal lung function (n = 920). Moreover, the risk increased significantly with severity of airflow limitation. On MRI, vulnerable lipid core plaques were more frequent in COPD cases than in controls (OR 2.1, 95%CI 1.25-3.69, p=0.0058). Conclusions: Carotid artery wall thickening is more prevalent in COPD patients than in controls. In elderly subjects with carotid wall thickening, COPD is an independent predictor for the presence of a lipid core, and therefore of vulnerable plaques.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Plaque, Carotid Intima-Media Thickness, Chronic Airflow Obstruction, Atherosclerotic, INTIMA-MEDIA THICKNESS, LUNG-FUNCTION, SUBCLINICAL ATHEROSCLEROSIS, CARDIOVASCULAR-DISEASE, COPD, RISK, COMORBIDITIES, ASSOCIATION, PROGRESSION, EMPHYSEMA, Intraplaque hemorrhage
journal title
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Am. J. Respir. Crit. Care Med.
volume
187
issue
1
pages
58 - 64
Web of Science type
Article
Web of Science id
000313606700012
JCR category
RESPIRATORY SYSTEM
JCR impact factor
11.986 (2013)
JCR rank
1/54 (2013)
JCR quartile
1 (2013)
ISSN
1073-449X
DOI
10.1164/rccm.201206-1046OC
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3067222
handle
http://hdl.handle.net/1854/LU-3067222
date created
2012-12-07 09:32:31
date last changed
2014-11-21 12:58:57
@article{3067222,
  abstract     = {Rationale: Chronic obstructive pulmonary disease (COPD) is an independent risk factor for ischemic stroke and the risk increases with severity of airflow limitation. Even though vulnerable carotid artery plaque components, such as intraplaque hemorrhage and lipid core, place persons at high risk for ischemic events, the plaque composition in COPD patients has never been explored.
Objectives: To investigate the prevalence of carotid wall thickening, the different carotid artery plaque components, and their relations with severity of airflow limitation in elderly patients with COPD.
Methods: This cross-sectional analysis was part of the Rotterdam Study, a prospective population-based cohort study performed in subjects aged 55 years and older. Diagnosis of COPD was confirmed by spirometry. Participants with carotid wall intima-media thickness (IMT) \ensuremath{\geq} 2.5 mm on ultrasonography underwent high-resolution magnetic resonance imaging (MRI) for characterization of carotid plaques. Data were analyzed using logistic regression.
Main Results: COPD cases (n = 253) had a twofold increased risk (OR 2.0, 95\%CI 1.44-2.85, p{\textlangle}0.0001) of presentation with carotid wall thickening on ultrasonography compared to controls with a normal lung function (n = 920). Moreover, the risk increased significantly with severity of airflow limitation. On MRI, vulnerable lipid core plaques were more frequent in COPD cases than in controls (OR 2.1, 95\%CI 1.25-3.69, p=0.0058).
Conclusions: Carotid artery wall thickening is more prevalent in COPD patients than in controls. In elderly subjects with carotid wall thickening, COPD is an independent predictor for the presence of a lipid core, and therefore of vulnerable plaques.},
  author       = {Lahousse, Lies and van den Bouwhuijsen, Quirijn JA and Loth, Daan W and Joos, Guy and Hofman, Albert and Witteman, Jacqueline CM and van der Lugt, Aad and Brusselle, Guy and Stricker, Bruno H},
  issn         = {1073-449X},
  journal      = {AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE},
  keyword      = {Plaque,Carotid Intima-Media Thickness,Chronic Airflow Obstruction,Atherosclerotic,INTIMA-MEDIA THICKNESS,LUNG-FUNCTION,SUBCLINICAL ATHEROSCLEROSIS,CARDIOVASCULAR-DISEASE,COPD,RISK,COMORBIDITIES,ASSOCIATION,PROGRESSION,EMPHYSEMA,Intraplaque hemorrhage},
  language     = {eng},
  number       = {1},
  pages        = {58--64},
  title        = {Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study},
  url          = {http://dx.doi.org/10.1164/rccm.201206-1046OC},
  volume       = {187},
  year         = {2013},
}

Chicago
Lahousse, Lies, Quirijn JA van den Bouwhuijsen, Daan W Loth, Guy Joos, Albert Hofman, Jacqueline CM Witteman, Aad van der Lugt, Guy Brusselle, and Bruno H Stricker. 2013. “Chronic Obstructive Pulmonary Disease and Lipid Core Carotid Artery Plaques in the Elderly: The Rotterdam Study.” American Journal of Respiratory and Critical Care Medicine 187 (1): 58–64.
APA
Lahousse, L., van den Bouwhuijsen, Q. J., Loth, D. W., Joos, G., Hofman, A., Witteman, J. C., van der Lugt, A., et al. (2013). Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(1), 58–64.
Vancouver
1.
Lahousse L, van den Bouwhuijsen QJ, Loth DW, Joos G, Hofman A, Witteman JC, et al. Chronic obstructive pulmonary disease and lipid core carotid artery plaques in the elderly: the Rotterdam Study. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2013;187(1):58–64.
MLA
Lahousse, Lies, Quirijn JA van den Bouwhuijsen, Daan W Loth, et al. “Chronic Obstructive Pulmonary Disease and Lipid Core Carotid Artery Plaques in the Elderly: The Rotterdam Study.” AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 187.1 (2013): 58–64. Print.