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Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature

Jelle van den Ameele UGent, ANNE SIEBEN UGent, Caroline Van den Broecke UGent, Tom Boterberg UGent, Luc Defreyne UGent, Eric Achten UGent, Martin Lammens UGent and DIMITRI HEMELSOET UGent (2012) ACTA NEUROLOGICA BELGICA. 112(1). p.101-104
abstract
Radiotherapy is extensively used in the treatment of malignant tumors of the central nervous system, but may also cause considerable morbidity and mortality, probably through damage to the remarkably vulnerable vascular system. We present two cases of infarction in the posterior cerebral vasculature related to earlier irradiation for a pineal gland tumor. Two patients were irradiated for a pineal gland tumor in young adulthood. Respectively 20 and 35 years later, they presented with a progressive neurological decline, related to early progressive atherosclerosis in the posterior cerebral vasculature. In conclusion, irradiation of the posterior cerebral territory may produce precocious atherosclerosis of posterior circulation vasculature, even decades later. When a progressive clinical decline with accumulating ischemic events is observed, together with signs of atherosclerosis, radiotherapy-related vasculopathy may be considered.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ISCHEMIC-STROKE, Stroke, Post-irradiation vasculopathy, Pinealoma, Posterior cerebral vasculature, RADIATION
journal title
ACTA NEUROLOGICA BELGICA
Acta Neurol. Belg.
volume
112
issue
1
pages
101 - 104
Web of Science type
Article
Web of Science id
000305226100021
JCR category
CLINICAL NEUROLOGY
JCR impact factor
0.466 (2012)
JCR rank
177/190 (2012)
JCR quartile
4 (2012)
ISSN
0300-9009
DOI
10.1007/s13760-012-0014-4
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3063688
handle
http://hdl.handle.net/1854/LU-3063688
date created
2012-12-02 21:19:42
date last changed
2015-06-17 10:19:24
@article{3063688,
  abstract     = {Radiotherapy is extensively used in the treatment of malignant tumors of the central nervous system, but may also cause considerable morbidity and mortality, probably through damage to the remarkably vulnerable vascular system. We present two cases of infarction in the posterior cerebral vasculature related to earlier irradiation for a pineal gland tumor. Two patients were irradiated for a pineal gland tumor in young adulthood. Respectively 20 and 35 years later, they presented with a progressive neurological decline, related to early progressive atherosclerosis in the posterior cerebral vasculature. In conclusion, irradiation of the posterior cerebral territory may produce precocious atherosclerosis of posterior circulation vasculature, even decades later. When a progressive clinical decline with accumulating ischemic events is observed, together with signs of atherosclerosis, radiotherapy-related vasculopathy may be considered.},
  author       = {van den Ameele, Jelle and SIEBEN, ANNE and Van den Broecke, Caroline and Boterberg, Tom and Defreyne, Luc and Achten, Eric and Lammens, Martin and HEMELSOET, DIMITRI},
  issn         = {0300-9009},
  journal      = {ACTA NEUROLOGICA BELGICA},
  keyword      = {ISCHEMIC-STROKE,Stroke,Post-irradiation vasculopathy,Pinealoma,Posterior cerebral vasculature,RADIATION},
  language     = {eng},
  number       = {1},
  pages        = {101--104},
  title        = {Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature},
  url          = {http://dx.doi.org/10.1007/s13760-012-0014-4},
  volume       = {112},
  year         = {2012},
}

Chicago
van den Ameele, Jelle, ANNE SIEBEN, Caroline Van den Broecke, Tom Boterberg, Luc Defreyne, Eric Achten, Martin Lammens, and Dimitri Hemelsoet. 2012. “Late-onset Post-irradiation Vasculopathy of the Posterior Cerebral Vasculature.” Acta Neurologica Belgica 112 (1): 101–104.
APA
van den Ameele, J., SIEBEN, A., Van den Broecke, C., Boterberg, T., Defreyne, L., Achten, E., Lammens, M., et al. (2012). Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature. ACTA NEUROLOGICA BELGICA, 112(1), 101–104.
Vancouver
1.
van den Ameele J, SIEBEN A, Van den Broecke C, Boterberg T, Defreyne L, Achten E, et al. Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature. ACTA NEUROLOGICA BELGICA. 2012;112(1):101–4.
MLA
van den Ameele, Jelle, ANNE SIEBEN, Caroline Van den Broecke, et al. “Late-onset Post-irradiation Vasculopathy of the Posterior Cerebral Vasculature.” ACTA NEUROLOGICA BELGICA 112.1 (2012): 101–104. Print.