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Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature

Jelle van den Ameele (UGent) , Anne Sieben (UGent) , Caroline Van den Broecke (UGent) , Tom Boterberg (UGent) , Luc Defreyne (UGent) , Eric Achten (UGent) , Martin Lammens (UGent) and Dimitri Hemelsoet (UGent)
(2012) ACTA NEUROLOGICA BELGICA. 112(1). p.101-104
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Abstract
Radiotherapy is extensively used in the treatment of malignant tumors of the central nervous system, but may also cause considerable morbidity and mortality, probably through damage to the remarkably vulnerable vascular system. We present two cases of infarction in the posterior cerebral vasculature related to earlier irradiation for a pineal gland tumor. Two patients were irradiated for a pineal gland tumor in young adulthood. Respectively 20 and 35 years later, they presented with a progressive neurological decline, related to early progressive atherosclerosis in the posterior cerebral vasculature. In conclusion, irradiation of the posterior cerebral territory may produce precocious atherosclerosis of posterior circulation vasculature, even decades later. When a progressive clinical decline with accumulating ischemic events is observed, together with signs of atherosclerosis, radiotherapy-related vasculopathy may be considered.
Keywords
ISCHEMIC-STROKE, Stroke, Post-irradiation vasculopathy, Pinealoma, Posterior cerebral vasculature, RADIATION

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Chicago
van den Ameele, Jelle, Anne Sieben, Caroline Van den Broecke, Tom Boterberg, Luc Defreyne, Eric Achten, Martin Lammens, and Dimitri Hemelsoet. 2012. “Late-onset Post-irradiation Vasculopathy of the Posterior Cerebral Vasculature.” Acta Neurologica Belgica 112 (1): 101–104.
APA
van den Ameele, J., Sieben, A., Van den Broecke, C., Boterberg, T., Defreyne, L., Achten, E., Lammens, M., et al. (2012). Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature. ACTA NEUROLOGICA BELGICA, 112(1), 101–104.
Vancouver
1.
van den Ameele J, Sieben A, Van den Broecke C, Boterberg T, Defreyne L, Achten E, et al. Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature. ACTA NEUROLOGICA BELGICA. 2012;112(1):101–4.
MLA
van den Ameele, Jelle, Anne Sieben, Caroline Van den Broecke, et al. “Late-onset Post-irradiation Vasculopathy of the Posterior Cerebral Vasculature.” ACTA NEUROLOGICA BELGICA 112.1 (2012): 101–104. Print.
@article{3063688,
  abstract     = {Radiotherapy is extensively used in the treatment of malignant tumors of the central nervous system, but may also cause considerable morbidity and mortality, probably through damage to the remarkably vulnerable vascular system. We present two cases of infarction in the posterior cerebral vasculature related to earlier irradiation for a pineal gland tumor. Two patients were irradiated for a pineal gland tumor in young adulthood. Respectively 20 and 35 years later, they presented with a progressive neurological decline, related to early progressive atherosclerosis in the posterior cerebral vasculature. In conclusion, irradiation of the posterior cerebral territory may produce precocious atherosclerosis of posterior circulation vasculature, even decades later. When a progressive clinical decline with accumulating ischemic events is observed, together with signs of atherosclerosis, radiotherapy-related vasculopathy may be considered.},
  author       = {van den Ameele, Jelle and Sieben, Anne and Van den Broecke, Caroline and Boterberg, Tom and Defreyne, Luc and Achten, Eric and Lammens, Martin and Hemelsoet, Dimitri},
  issn         = {0300-9009},
  journal      = {ACTA NEUROLOGICA BELGICA},
  keyword      = {ISCHEMIC-STROKE,Stroke,Post-irradiation vasculopathy,Pinealoma,Posterior cerebral vasculature,RADIATION},
  language     = {eng},
  number       = {1},
  pages        = {101--104},
  title        = {Late-onset post-irradiation vasculopathy of the posterior cerebral vasculature},
  url          = {http://dx.doi.org/10.1007/s13760-012-0014-4},
  volume       = {112},
  year         = {2012},
}

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