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Threshold retinopathy at threshold of viability: the EpiBel study

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Abstract
Aim: To describe incidence, co-morbidity characteristics, and risk factors associated with threshold retinopathy of prematurity (ROP) in survivors with a gestational age (GA) of (26 weeks at birth. Methods: Retrospective analysis of perinatal data of all inborn survivors in all perinatal centres of Belgium in the period 1999-2000 (EpiBel cohort) believed to be between 22 and 26 weeks GA at time of delivery. Data on survivors who did and survivors who did not develop threshold ROP were compared (chi(2), Mann-Whitney U) and logistic regression was performed. Results: Of 303 admitted infants 175 (58%) were discharged alive. Incidence of major retinopathy (greater than or equal tostage 3) and of threshold ROP was 25.5% and 19.8% in survivors. Associated central nervous abnormalities were documented in six (17%) and associated chronic lung disease in 19 (54%) threshold ROP infants. Threshold ROP without additional morbidity characteristics at discharge was documented in 14 (40%) infants. Besides often reported risk factors, renal insufficiency (creatinaemia. 1.5 mg/dl) was a risk factor to develop threshold ROP (p < 0.0015) (χ(2)). Days of respiratory support (OR 1.02; 95% CI 1.002 to 1.039), number of transfusions (OR 1.118; 95% CI 1.030 to 1.214), and renal insufficiency (OR 3.31; 95% CI 1.344 to 8.196) remained independent risk factors to develop threshold ROP in this cohort in a stepwise logistic regression model (MedCalc). Conclusions: Incidence of threshold ROP is high at the limits of viability. Renal insufficiency is a risk factor to develop threshold ROP in this cohort.
Keywords
BABIES SCORE, CLINICAL RISK INDEX, PREMATURITY, INFANTS

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Chicago
Allegaert, K, Kris De Coen, and H Devlieger. 2004. “Threshold Retinopathy at Threshold of Viability: The EpiBel Study.” British Journal of Ophthalmology 88 (2): 239–242.
APA
Allegaert, K, De Coen, K., & Devlieger, H. (2004). Threshold retinopathy at threshold of viability: the EpiBel study. BRITISH JOURNAL OF OPHTHALMOLOGY, 88(2), 239–242. Presented at the 18th European congress of Perinatal Medicine.
Vancouver
1.
Allegaert K, De Coen K, Devlieger H. Threshold retinopathy at threshold of viability: the EpiBel study. BRITISH JOURNAL OF OPHTHALMOLOGY. 2004;88(2):239–42.
MLA
Allegaert, K, Kris De Coen, and H Devlieger. “Threshold Retinopathy at Threshold of Viability: The EpiBel Study.” BRITISH JOURNAL OF OPHTHALMOLOGY 88.2 (2004): 239–242. Print.
@article{305970,
  abstract     = {Aim: To describe incidence, co-morbidity characteristics, and risk factors associated with threshold retinopathy of prematurity (ROP) in survivors with a gestational age (GA) of (26 weeks at birth. 
Methods: Retrospective analysis of perinatal data of all inborn survivors in all perinatal centres of Belgium in the period 1999-2000 (EpiBel cohort) believed to be between 22 and 26 weeks GA at time of delivery. Data on survivors who did and survivors who did not develop threshold ROP were compared (chi(2), Mann-Whitney U) and logistic regression was performed. 
Results: Of 303 admitted infants 175 (58\%) were discharged alive. Incidence of major retinopathy (greater than or equal tostage 3) and of threshold ROP was 25.5\% and 19.8\% in survivors. Associated central nervous abnormalities were documented in six (17\%) and associated chronic lung disease in 19 (54\%) threshold ROP infants. Threshold ROP without additional morbidity characteristics at discharge was documented in 14 (40\%) infants. Besides often reported risk factors, renal insufficiency (creatinaemia. 1.5 mg/dl) was a risk factor to develop threshold ROP (p {\textlangle} 0.0015) (\ensuremath{\chi}(2)). Days of respiratory support (OR 1.02; 95\% CI 1.002 to 1.039), number of transfusions (OR 1.118; 95\% CI 1.030 to 1.214), and renal insufficiency (OR 3.31; 95\% CI 1.344 to 8.196) remained independent risk factors to develop threshold ROP in this cohort in a stepwise logistic regression model (MedCalc). 
Conclusions: Incidence of threshold ROP is high at the limits of viability. Renal insufficiency is a risk factor to develop threshold ROP in this cohort.},
  author       = {Allegaert, K and De Coen, Kris and Devlieger, H},
  issn         = {0007-1161},
  journal      = {BRITISH JOURNAL OF OPHTHALMOLOGY},
  language     = {eng},
  location     = {Oslo, Norway},
  number       = {2},
  pages        = {239--242},
  title        = {Threshold retinopathy at threshold of viability: the EpiBel study},
  url          = {http://dx.doi.org/10.1136/bjo.2003.027474},
  volume       = {88},
  year         = {2004},
}

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