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Auxin and epigenetic regulation of SKP2B, an F-box that represses lateral root formation

Concepción Manzano, Elena Ramirez-Parra, Ilda Casimiro, Sofía Otero, Bénédicte Desvoyes, Bert De Rybel UGent, Tom Beeckman UGent, Pedro Casero, Crisanto Gutierrez and Juan C del Pozo (2012) PLANT PHYSIOLOGY. 160(2). p.749-762
abstract
In plants, lateral roots originate from pericycle founder cells that are specified at regular intervals along the main root. Here, we show that Arabidopsis (Arabidopsis thaliana) SKP2B (for S-Phase Kinase-Associated Protein2B), an F-box protein, negatively regulates cell cycle and lateral root formation as it represses meristematic and founder cell divisions. According to its function, SKP2B is expressed in founder cells, lateral root primordia and the root apical meristem. We identified a novel motif in the SKP2B promoter that is required for its specific root expression and auxin-dependent induction in the pericycle cells. Next to a transcriptional control by auxin, SKP2B expression is regulated by histone H3.1/H3.3 deposition in a CAF-dependent manner. The SKP2B promoter and the 59 end of the transcribed region are enriched in H3.3, which is associated with active chromatin states, over H3.1. Furthermore, the SKP2B promoter is also regulated by H3 acetylation in an auxin-and IAA14-dependent manner, reinforcing the idea that epigenetics represents an important regulatory mechanism during lateral root formation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CELL-CYCLE PROGRESSION, UBIQUITIN-MEDIATED DEGRADATION, ARABIDOPSIS-THALIANA, HISTONE VARIANT H3.3, PATHWAY, INITIATION, TRANSCRIPTION FACTORS, ACTIVE CHROMATIN, GENE-EXPRESSION, PROTEIN
journal title
PLANT PHYSIOLOGY
Plant Physiol.
volume
160
issue
2
pages
749 - 762
Web of Science type
Article
Web of Science id
000309523800015
JCR category
PLANT SCIENCES
JCR impact factor
6.555 (2012)
JCR rank
8/193 (2012)
JCR quartile
1 (2012)
ISSN
0032-0889
DOI
10.1104/pp.112.198341
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3059379
handle
http://hdl.handle.net/1854/LU-3059379
date created
2012-11-23 15:48:37
date last changed
2017-02-22 14:40:45
@article{3059379,
  abstract     = {In plants, lateral roots originate from pericycle founder cells that are specified at regular intervals along the main root. Here, we show that Arabidopsis (Arabidopsis thaliana) SKP2B (for S-Phase Kinase-Associated Protein2B), an F-box protein, negatively regulates cell cycle and lateral root formation as it represses meristematic and founder cell divisions. According to its function, SKP2B is expressed in founder cells, lateral root primordia and the root apical meristem. We identified a novel motif in the SKP2B promoter that is required for its specific root expression and auxin-dependent induction in the pericycle cells. Next to a transcriptional control by auxin, SKP2B expression is regulated by histone H3.1/H3.3 deposition in a CAF-dependent manner. The SKP2B promoter and the 59 end of the transcribed region are enriched in H3.3, which is associated with active chromatin states, over H3.1. Furthermore, the SKP2B promoter is also regulated by H3 acetylation in an auxin-and IAA14-dependent manner, reinforcing the idea that epigenetics represents an important regulatory mechanism during lateral root formation.},
  author       = {Manzano, Concepci{\'o}n and Ramirez-Parra, Elena and Casimiro, Ilda and Otero, Sof{\'i}a and Desvoyes, B{\'e}n{\'e}dicte and De Rybel, Bert and Beeckman, Tom and Casero, Pedro and Gutierrez, Crisanto and del Pozo, Juan C},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keyword      = {CELL-CYCLE PROGRESSION,UBIQUITIN-MEDIATED DEGRADATION,ARABIDOPSIS-THALIANA,HISTONE VARIANT H3.3,PATHWAY,INITIATION,TRANSCRIPTION FACTORS,ACTIVE CHROMATIN,GENE-EXPRESSION,PROTEIN},
  language     = {eng},
  number       = {2},
  pages        = {749--762},
  title        = {Auxin and epigenetic regulation of SKP2B, an F-box that represses lateral root formation},
  url          = {http://dx.doi.org/10.1104/pp.112.198341},
  volume       = {160},
  year         = {2012},
}

Chicago
Manzano, Concepción, Elena Ramirez-Parra, Ilda Casimiro, Sofía Otero, Bénédicte Desvoyes, Bert De Rybel, Tom Beeckman, Pedro Casero, Crisanto Gutierrez, and Juan C del Pozo. 2012. “Auxin and Epigenetic Regulation of SKP2B, an F-box That Represses Lateral Root Formation.” Plant Physiology 160 (2): 749–762.
APA
Manzano, C., Ramirez-Parra, E., Casimiro, I., Otero, S., Desvoyes, B., De Rybel, B., Beeckman, T., et al. (2012). Auxin and epigenetic regulation of SKP2B, an F-box that represses lateral root formation. PLANT PHYSIOLOGY, 160(2), 749–762.
Vancouver
1.
Manzano C, Ramirez-Parra E, Casimiro I, Otero S, Desvoyes B, De Rybel B, et al. Auxin and epigenetic regulation of SKP2B, an F-box that represses lateral root formation. PLANT PHYSIOLOGY. 2012;160(2):749–62.
MLA
Manzano, Concepción, Elena Ramirez-Parra, Ilda Casimiro, et al. “Auxin and Epigenetic Regulation of SKP2B, an F-box That Represses Lateral Root Formation.” PLANT PHYSIOLOGY 160.2 (2012): 749–762. Print.