Advanced search
1 file | 171.77 KB

Long-term evaluation of cross-sex hormone treatment in transsexual persons

Katrien Wierckx, Sven Müller (UGent) , Steven Weyers (UGent) , Eva Van Caenegem (UGent) , GREET ROEF (UGent) , GUNTER HEYLENS (UGent) and Guy T'Sjoen (UGent)
(2012) JOURNAL OF SEXUAL MEDICINE. 9(10). p.2641-2651
Author
Organization
Abstract
Introduction. Long-term effects and side effects of cross-sex hormone treatment in transsexual persons are not well known. Aim. The aim of this study is to describe the effects and side effects of cross-sex hormone therapy in both transsexual men and women. Main Outcome Measures. Hormone levels were measured by immunoassays. Physical health was assessed by physical examination and questionnaires on general health and specific side effects, areal bone parameters by dual energy X-ray absorptiometry. Methods. Single center cross-sectional study in 100 transsexual persons post-sex reassignment surgery and on average 10 years on cross-sex hormone therapy. Results. Transsexual men did not experience important side effects such as cardiovascular events, hormone-related cancers, or osteoporosis. In contrast, a quarter of the transsexual women had osteoporosis at the lumbar spine and radius. Moreover, 6% of transsexual women experienced a thromboembolic event and another 6% experienced other cardiovascular problems after on average 11.3 hormone treatment years. None of the transsexual women experienced a hormone-related cancer during treatment. Conclusion. Cross-sex hormone treatment appears to be safe in transsexual men. On the other hand, a substantial number of transsexual women suffered from osteoporosis at the lumbar spine and distal arm. Twelve percent of transsexual women experienced thromboembolic and/or other cardiovascular events during hormone treatment, possibly related to older age, estrogen treatment, and lifestyle factors. In order to decrease cardiovascular morbidity, more attention should be paid to decrease cardiovascular risk factors during hormone therapy management.
Keywords
Gender Identity Disorder, Osteoporosis, Thrombosis, Side Effects, Hormone Therapy, Transsexualism, BONE-MINERAL DENSITY, ANDROGEN-DEPRIVATION THERAPY, TO-MALE TRANSSEXUALS, LIFE-STYLE FACTORS, ENDOCRINE TREATMENT, FEMALE TRANSSEXUALS, ORAL-CONTRACEPTIVES, REPLACEMENT THERAPY, VENOUS THROMBOEMBOLISM, REASSIGNMENT SURGERY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 171.77 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Wierckx, Katrien, Sven Müller, Steven Weyers, Eva Van Caenegem, GREET ROEF, GUNTER HEYLENS, and Guy T’Sjoen. 2012. “Long-term Evaluation of Cross-sex Hormone Treatment in Transsexual Persons.” Journal of Sexual Medicine 9 (10): 2641–2651.
APA
Wierckx, K., Müller, S., Weyers, S., Van Caenegem, E., ROEF, G., HEYLENS, G., & T’Sjoen, G. (2012). Long-term evaluation of cross-sex hormone treatment in transsexual persons. JOURNAL OF SEXUAL MEDICINE, 9(10), 2641–2651.
Vancouver
1.
Wierckx K, Müller S, Weyers S, Van Caenegem E, ROEF G, HEYLENS G, et al. Long-term evaluation of cross-sex hormone treatment in transsexual persons. JOURNAL OF SEXUAL MEDICINE. 2012;9(10):2641–51.
MLA
Wierckx, Katrien, Sven Müller, Steven Weyers, et al. “Long-term Evaluation of Cross-sex Hormone Treatment in Transsexual Persons.” JOURNAL OF SEXUAL MEDICINE 9.10 (2012): 2641–2651. Print.
@article{3056647,
  abstract     = {Introduction. Long-term effects and side effects of cross-sex hormone treatment in transsexual persons are not well known.
Aim. The aim of this study is to describe the effects and side effects of cross-sex hormone therapy in both transsexual men and women.
Main Outcome Measures. Hormone levels were measured by immunoassays. Physical health was assessed by physical examination and questionnaires on general health and specific side effects, areal bone parameters by dual energy X-ray absorptiometry.
Methods. Single center cross-sectional study in 100 transsexual persons post-sex reassignment surgery and on average 10 years on cross-sex hormone therapy.
Results. Transsexual men did not experience important side effects such as cardiovascular events, hormone-related cancers, or osteoporosis. In contrast, a quarter of the transsexual women had osteoporosis at the lumbar spine and radius. Moreover, 6\% of transsexual women experienced a thromboembolic event and another 6\% experienced other cardiovascular problems after on average 11.3 hormone treatment years. None of the transsexual women experienced a hormone-related cancer during treatment.
Conclusion. Cross-sex hormone treatment appears to be safe in transsexual men. On the other hand, a substantial number of transsexual women suffered from osteoporosis at the lumbar spine and distal arm. Twelve percent of transsexual women experienced thromboembolic and/or other cardiovascular events during hormone treatment, possibly related to older age, estrogen treatment, and lifestyle factors. In order to decrease cardiovascular morbidity, more attention should be paid to decrease cardiovascular risk factors during hormone therapy management.},
  author       = {Wierckx, Katrien and M{\"u}ller, Sven and Weyers, Steven and Van Caenegem, Eva and ROEF, GREET and HEYLENS, GUNTER and T'Sjoen, Guy},
  issn         = {1743-6095},
  journal      = {JOURNAL OF SEXUAL MEDICINE},
  keyword      = {Gender Identity Disorder,Osteoporosis,Thrombosis,Side Effects,Hormone Therapy,Transsexualism,BONE-MINERAL DENSITY,ANDROGEN-DEPRIVATION THERAPY,TO-MALE TRANSSEXUALS,LIFE-STYLE FACTORS,ENDOCRINE TREATMENT,FEMALE TRANSSEXUALS,ORAL-CONTRACEPTIVES,REPLACEMENT THERAPY,VENOUS THROMBOEMBOLISM,REASSIGNMENT SURGERY},
  language     = {eng},
  number       = {10},
  pages        = {2641--2651},
  title        = {Long-term evaluation of cross-sex hormone treatment in transsexual persons},
  url          = {http://dx.doi.org/10.1111/j.1743-6109.2012.02876.x},
  volume       = {9},
  year         = {2012},
}

Altmetric
View in Altmetric
Web of Science
Times cited: