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Incentive processing in Congenital Adrenal Hyperplasia (CAH): a reward-based antisaccade study

(2013) PSYCHONEUROENDOCRINOLOGY. 38(5). p.716-721
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The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Little is known about how steroid hormones contribute to the beneficial effect of incentives on cognitive control during adolescent development. In this study, 27 adolescents with Congenital Adrenal Hyperplasia (CAH, mean age 15.6 years, 12 female), a disorder of cortisol deficiency and androgen excess, and 36 healthy participants (mean age 16.3 years, 18 female) completed a reward-based antisaccade task. In this mixed-saccade task, participants performed eye movements towards (prosaccades) or away (antisaccades) from a peripherally occuring stimulus. On incentive trials, monetary reward was provided for correct performance, while no such reward was provided on no-incentive trials. Consistent with the hypothesis, the results showed that healthy, but not CAH adolescents, significantly improved their inhibitory control (antisaccade accuracy) during incentive trials relative to no-incentive trials. These findings were not driven by severity of CAH (salt wasters vs. simple virilizers), individual hormone levels, sex, age-at-diagnosis, or medication type (dexamethasone vs. hydrocortisone). In addition, no significant differences between groups were found on orienting responses (prosaccades). Additional analyses revealed an impact of glucocorticoid (GC) dosage, such that higher GC dose predicted better antisaccade performance. However, this effect did not impact incentive processing. The data are discussed within the context of steroid hormone mediated effects on cognitive control and reward processing.
Keywords
EARLY STEROID ABNORMALITIES, HIPPOCAMPAL-FORMATION, INHIBITORY CONTROL, DOPAMINE RELEASE, DEPRESSIVE STATE, STRESS, ADOLESCENTS, DISORDER, SUPPRESSION, PERFORMANCE, Inhibitory control, Androgen, Development, Adolescence, Sex steroids, Testosterone, Cortisol

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Citation

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Chicago
Müller, Sven, Teresa Daniele, Jessica Macintyre, Katherine Korelitz, Christina Carlisi, Michael Hardin, Carol VanRyzin, Deborah Merke, and Monique Ernst. 2013. “Incentive Processing in Congenital Adrenal Hyperplasia (CAH): a Reward-based Antisaccade Study.” Psychoneuroendocrinology 38 (5): 716–721.
APA
Müller, Sven, Daniele, T., Macintyre, J., Korelitz, K., Carlisi, C., Hardin, M., VanRyzin, C., et al. (2013). Incentive processing in Congenital Adrenal Hyperplasia (CAH): a reward-based antisaccade study. PSYCHONEUROENDOCRINOLOGY, 38(5), 716–721.
Vancouver
1.
Müller S, Daniele T, Macintyre J, Korelitz K, Carlisi C, Hardin M, et al. Incentive processing in Congenital Adrenal Hyperplasia (CAH): a reward-based antisaccade study. PSYCHONEUROENDOCRINOLOGY. 2013;38(5):716–21.
MLA
Müller, Sven, Teresa Daniele, Jessica Macintyre, et al. “Incentive Processing in Congenital Adrenal Hyperplasia (CAH): a Reward-based Antisaccade Study.” PSYCHONEUROENDOCRINOLOGY 38.5 (2013): 716–721. Print.
@article{3056348,
  abstract     = {Little is known about how steroid hormones contribute to the beneficial effect of incentives on cognitive control during adolescent development. In this study, 27 adolescents with Congenital Adrenal Hyperplasia (CAH, mean age 15.6 years, 12 female), a disorder of cortisol deficiency and androgen excess, and 36 healthy participants (mean age 16.3 years, 18 female) completed a reward-based antisaccade task. In this mixed-saccade task, participants performed eye movements towards (prosaccades) or away (antisaccades) from a peripherally occuring stimulus. On incentive trials, monetary reward was provided for correct performance, while no such reward was provided on no-incentive trials. Consistent with the hypothesis, the results showed that healthy, but not CAH adolescents, significantly improved their inhibitory control (antisaccade accuracy) during incentive trials relative to no-incentive trials. These findings were not driven by severity of CAH (salt wasters vs. simple virilizers), individual hormone levels, sex, age-at-diagnosis, or medication type (dexamethasone vs. hydrocortisone). In addition, no significant differences between groups were found on orienting responses (prosaccades). Additional analyses revealed an impact of glucocorticoid (GC) dosage, such that higher GC dose predicted better antisaccade performance. However, this effect did not impact incentive processing. The data are discussed within the context of steroid hormone mediated effects on cognitive control and reward processing.},
  author       = {M{\"u}ller, Sven and Daniele, Teresa and Macintyre, Jessica and Korelitz, Katherine and Carlisi, Christina and Hardin, Michael and VanRyzin, Carol and Merke, Deborah  and Ernst, Monique},
  issn         = {0306-4530},
  journal      = {PSYCHONEUROENDOCRINOLOGY},
  keyword      = {EARLY STEROID ABNORMALITIES,HIPPOCAMPAL-FORMATION,INHIBITORY CONTROL,DOPAMINE RELEASE,DEPRESSIVE STATE,STRESS,ADOLESCENTS,DISORDER,SUPPRESSION,PERFORMANCE,Inhibitory control,Androgen,Development,Adolescence,Sex steroids,Testosterone,Cortisol},
  language     = {eng},
  number       = {5},
  pages        = {716--721},
  title        = {Incentive processing in Congenital Adrenal Hyperplasia (CAH): a reward-based antisaccade study},
  url          = {http://dx.doi.org/10.1016/j.psyneuen.2012.08.001},
  volume       = {38},
  year         = {2013},
}

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