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Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens

(2012) JOURNAL OF BIOLOGICAL CHEMISTRY. 287(41). p.34474-34483
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Abstract
Enteric pathogens represent a major cause of morbidity and mortality worldwide. Toll-like receptor (TLR) and inflammasome signaling are critical for host responses against these pathogens, but how these pathways are integrated remains unclear. Here, we show that TLR4 and the TLR adaptor TRIF are required for inflammasome activation in macrophages infected with the enteric pathogens Escherichia coli and Citrobacter rodentium. In contrast, TLR4 and TRIF were dispensable for Salmonella typhimurium-induced caspase-1 activation. TRIF regulated expression of caspase-11, a caspase-1-related protease that is critical for E. coli-and C. rodentium-induced inflammasome activation, but dispensable for inflammasome activation by S. typhimurium. Thus, TLR4- and TRIF-induced caspase-11 synthesis is critical for noncanonical Nlrp3 inflammasome activation in macrophages infected with enteric pathogens.
Keywords
MICE, INFECTION, INNATE, ACTIVATION, SIGNALING PATHWAY, PATTERN-RECOGNITION, CRYOPYRIN INFLAMMASOME, CITROBACTER-RODENTIUM, CUTTING EDGE, IMMUNITY

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Citation

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Chicago
Gurung, Prajwal, RK Subbarao Malireddi, Paras K Anand, Dieter Demon, Lieselotte Vande Walle, ZhiPing Liu, Peter Vogel, Mohamed Lamkanfi, and Thirumala-Devi Kanneganti. 2012. “Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense Against Enteropathogens.” Journal of Biological Chemistry 287 (41): 34474–34483.
APA
Gurung, P., Malireddi, R. S., Anand, P. K., Demon, D., Vande Walle, L., Liu, Z., Vogel, P., et al. (2012). Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(41), 34474–34483.
Vancouver
1.
Gurung P, Malireddi RS, Anand PK, Demon D, Vande Walle L, Liu Z, et al. Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens. JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(41):34474–83.
MLA
Gurung, Prajwal, RK Subbarao Malireddi, Paras K Anand, et al. “Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense Against Enteropathogens.” JOURNAL OF BIOLOGICAL CHEMISTRY 287.41 (2012): 34474–34483. Print.
@article{3054609,
  abstract     = {Enteric pathogens represent a major cause of morbidity and mortality worldwide. Toll-like receptor (TLR) and inflammasome signaling are critical for host responses against these pathogens, but how these pathways are integrated remains unclear. Here, we show that TLR4 and the TLR adaptor TRIF are required for inflammasome activation in macrophages infected with the enteric pathogens Escherichia coli and Citrobacter rodentium. In contrast, TLR4 and TRIF were dispensable for Salmonella typhimurium-induced caspase-1 activation. TRIF regulated expression of caspase-11, a caspase-1-related protease that is critical for E. coli-and C. rodentium-induced inflammasome activation, but dispensable for inflammasome activation by S. typhimurium. Thus, TLR4- and TRIF-induced caspase-11 synthesis is critical for noncanonical Nlrp3 inflammasome activation in macrophages infected with enteric pathogens.},
  author       = {Gurung, Prajwal and Malireddi, RK Subbarao and Anand, Paras K and Demon, Dieter and Vande Walle, Lieselotte and Liu, ZhiPing and Vogel, Peter and Lamkanfi, Mohamed and Kanneganti, Thirumala-Devi},
  issn         = {0021-9258},
  journal      = {JOURNAL OF BIOLOGICAL CHEMISTRY},
  keyword      = {MICE,INFECTION,INNATE,ACTIVATION,SIGNALING PATHWAY,PATTERN-RECOGNITION,CRYOPYRIN INFLAMMASOME,CITROBACTER-RODENTIUM,CUTTING EDGE,IMMUNITY},
  language     = {eng},
  number       = {41},
  pages        = {34474--34483},
  title        = {Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-\ensuremath{\beta} (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens},
  url          = {http://dx.doi.org/10.1074/jbc.M112.401406},
  volume       = {287},
  year         = {2012},
}

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