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Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens

Prajwal Gurung, RK Subbarao Malireddi, Paras K Anand, Dieter Demon UGent, Lieselotte Vande Walle UGent, ZhiPing Liu, Peter Vogel, Mohamed Lamkanfi UGent and Thirumala-Devi Kanneganti (2012) JOURNAL OF BIOLOGICAL CHEMISTRY. 287(41). p.34474-34483
abstract
Enteric pathogens represent a major cause of morbidity and mortality worldwide. Toll-like receptor (TLR) and inflammasome signaling are critical for host responses against these pathogens, but how these pathways are integrated remains unclear. Here, we show that TLR4 and the TLR adaptor TRIF are required for inflammasome activation in macrophages infected with the enteric pathogens Escherichia coli and Citrobacter rodentium. In contrast, TLR4 and TRIF were dispensable for Salmonella typhimurium-induced caspase-1 activation. TRIF regulated expression of caspase-11, a caspase-1-related protease that is critical for E. coli-and C. rodentium-induced inflammasome activation, but dispensable for inflammasome activation by S. typhimurium. Thus, TLR4- and TRIF-induced caspase-11 synthesis is critical for noncanonical Nlrp3 inflammasome activation in macrophages infected with enteric pathogens.
Please use this url to cite or link to this publication:
author
organization
alternative title
Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-beta (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens
year
type
journalArticle (original)
publication status
published
subject
keyword
MICE, INFECTION, INNATE, ACTIVATION, SIGNALING PATHWAY, PATTERN-RECOGNITION, CRYOPYRIN INFLAMMASOME, CITROBACTER-RODENTIUM, CUTTING EDGE, IMMUNITY
journal title
JOURNAL OF BIOLOGICAL CHEMISTRY
J. Biol. Chem.
volume
287
issue
41
pages
34474 - 34483
Web of Science type
Article
Web of Science id
000309654200049
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
4.651 (2012)
JCR rank
61/288 (2012)
JCR quartile
1 (2012)
ISSN
0021-9258
DOI
10.1074/jbc.M112.401406
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3054609
handle
http://hdl.handle.net/1854/LU-3054609
date created
2012-11-19 14:20:09
date last changed
2012-11-19 15:02:41
@article{3054609,
  abstract     = {Enteric pathogens represent a major cause of morbidity and mortality worldwide. Toll-like receptor (TLR) and inflammasome signaling are critical for host responses against these pathogens, but how these pathways are integrated remains unclear. Here, we show that TLR4 and the TLR adaptor TRIF are required for inflammasome activation in macrophages infected with the enteric pathogens Escherichia coli and Citrobacter rodentium. In contrast, TLR4 and TRIF were dispensable for Salmonella typhimurium-induced caspase-1 activation. TRIF regulated expression of caspase-11, a caspase-1-related protease that is critical for E. coli-and C. rodentium-induced inflammasome activation, but dispensable for inflammasome activation by S. typhimurium. Thus, TLR4- and TRIF-induced caspase-11 synthesis is critical for noncanonical Nlrp3 inflammasome activation in macrophages infected with enteric pathogens.},
  author       = {Gurung, Prajwal and Malireddi, RK Subbarao and Anand, Paras K and Demon, Dieter and Vande Walle, Lieselotte and Liu, ZhiPing and Vogel, Peter and Lamkanfi, Mohamed and Kanneganti, Thirumala-Devi},
  issn         = {0021-9258},
  journal      = {JOURNAL OF BIOLOGICAL CHEMISTRY},
  keyword      = {MICE,INFECTION,INNATE,ACTIVATION,SIGNALING PATHWAY,PATTERN-RECOGNITION,CRYOPYRIN INFLAMMASOME,CITROBACTER-RODENTIUM,CUTTING EDGE,IMMUNITY},
  language     = {eng},
  number       = {41},
  pages        = {34474--34483},
  title        = {Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-\ensuremath{\beta} (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens},
  url          = {http://dx.doi.org/10.1074/jbc.M112.401406},
  volume       = {287},
  year         = {2012},
}

Chicago
Gurung, Prajwal, RK Subbarao Malireddi, Paras K Anand, Dieter Demon, Lieselotte Vande Walle, ZhiPing Liu, Peter Vogel, Mohamed Lamkanfi, and Thirumala-Devi Kanneganti. 2012. “Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense Against Enteropathogens.” Journal of Biological Chemistry 287 (41): 34474–34483.
APA
Gurung, P., Malireddi, R. S., Anand, P. K., Demon, D., Vande Walle, L., Liu, Z., Vogel, P., et al. (2012). Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(41), 34474–34483.
Vancouver
1.
Gurung P, Malireddi RS, Anand PK, Demon D, Vande Walle L, Liu Z, et al. Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)-mediated caspase-11 protease production integrates toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome-mediated host defense against enteropathogens. JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(41):34474–83.
MLA
Gurung, Prajwal, RK Subbarao Malireddi, Paras K Anand, et al. “Toll or Interleukin-1 Receptor (TIR) Domain-containing Adaptor Inducing Interferon-β (TRIF)-mediated Caspase-11 Protease Production Integrates Toll-like Receptor 4 (TLR4) Protein- and Nlrp3 Inflammasome-mediated Host Defense Against Enteropathogens.” JOURNAL OF BIOLOGICAL CHEMISTRY 287.41 (2012): 34474–34483. Print.