@article{3053197,
  abstract     = {{Context : The literature provides no clear answer as to whether total oestradiol (E2) concentrations increase the risk of incident cardiovascular disease (CVD) in healthy men. 
Objective : The authors conducted a systematic review and meta-analysis to estimate the predictive value of E2 for CVD, and to identify study features explaining conflicting results. 
Data sources : Articles were identified by a Medline and Embase search and citation tracking. 
Study selection : Eligible articles were prospective population-based cohorts and nested case-control studies on E2 and incident cardiovascular disease (CVD), including myocardial infarction, stroke or death from coronary heart disease. 
Data-extraction : Independent researchers re-expressed associations of E2 and incident CVD in a uniform manner to be used in meta-regression analyses for identification of study features explaining conflicting results, and to estimate the predictive value of E2 for CVD. 
Results and conclusions : 14 studies out of 128 electronically identified articles were eligible. Data to be used for meta-analysis could be calculated in seven cases, and in the remaining seven cases, data of three more became available by contacting those authors. Overall, a non-significant association was found with an estimated summary RR of 0.98 for a change of >75th versus <25th percentile in E2 (95% CI 0.74 to 1.31). Mean body mass index (BMI) of the study population (beta s -0.8, p<0.004), and quality of E2 assay (beta s -0.6, p<0.08) may have modified the relationship between E2 and incident CVD. The present systematic review does not provide evidence for a pronounced harmful or beneficial effect of E2 on risk for incident CVD in healthy men. If present, an effect of E2 on risk for CVD might be modulated by BMI.}},
  author       = {{VANDENPLAS, GUY and De Bacquer, Dirk and Calders, Patrick and Fiers, Tom and Kaufman, Jean and Ouwens, D Margriet and Ruige, Johannes}},
  issn         = {{1355-6037}},
  journal      = {{HEART}},
  keywords     = {{MIDDLE-AGED MEN,ELDERLY SWEDISH MEN,LOW SERUM TESTOSTERONE,CORONARY-ARTERY-DISEASE,SEX-HORMONES,HEART-DISEASE,CAROTID ATHEROSCLEROSIS,MYOCARDIAL-INFARCTION,RISK-FACTORS,MORTALITY}},
  language     = {{eng}},
  number       = {{20}},
  pages        = {{1478--1482}},
  title        = {{Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies}},
  url          = {{http://doi.org/10.1136/heartjnl-2011-301587}},
  volume       = {{98}},
  year         = {{2012}},
}

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