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Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies

GUY VANDENPLAS UGent, Dirk De Bacquer UGent, Patrick Calders UGent, TOM FIERS UGent, Jean Kaufman UGent, D Margriet Ouwens and Johannes Ruige UGent (2012) HEART. 98(20). p.1478-1482
abstract
Context : The literature provides no clear answer as to whether total oestradiol (E2) concentrations increase the risk of incident cardiovascular disease (CVD) in healthy men. Objective : The authors conducted a systematic review and meta-analysis to estimate the predictive value of E2 for CVD, and to identify study features explaining conflicting results. Data sources : Articles were identified by a Medline and Embase search and citation tracking. Study selection : Eligible articles were prospective population-based cohorts and nested case-control studies on E2 and incident cardiovascular disease (CVD), including myocardial infarction, stroke or death from coronary heart disease. Data-extraction : Independent researchers re-expressed associations of E2 and incident CVD in a uniform manner to be used in meta-regression analyses for identification of study features explaining conflicting results, and to estimate the predictive value of E2 for CVD. Results and conclusions : 14 studies out of 128 electronically identified articles were eligible. Data to be used for meta-analysis could be calculated in seven cases, and in the remaining seven cases, data of three more became available by contacting those authors. Overall, a non-significant association was found with an estimated summary RR of 0.98 for a change of >75th versus <25th percentile in E2 (95% CI 0.74 to 1.31). Mean body mass index (BMI) of the study population (beta s -0.8, p<0.004), and quality of E2 assay (beta s -0.6, p<0.08) may have modified the relationship between E2 and incident CVD. The present systematic review does not provide evidence for a pronounced harmful or beneficial effect of E2 on risk for incident CVD in healthy men. If present, an effect of E2 on risk for CVD might be modulated by BMI.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
ELDERLY SWEDISH MEN, MIDDLE-AGED MEN, LOW SERUM TESTOSTERONE, CORONARY-ARTERY-DISEASE, SEX-HORMONES, HEART-DISEASE, CAROTID ATHEROSCLEROSIS, MYOCARDIAL-INFARCTION, RISK-FACTORS, MORTALITY
journal title
HEART
Heart
volume
98
issue
20
pages
1478 - 1482
Web of Science type
Review
Web of Science id
000309116600004
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
5.014 (2012)
JCR rank
22/120 (2012)
JCR quartile
1 (2012)
ISSN
1355-6037
DOI
10.1136/heartjnl-2011-301587
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3053197
handle
http://hdl.handle.net/1854/LU-3053197
date created
2012-11-14 16:21:11
date last changed
2012-11-19 11:26:42
@article{3053197,
  abstract     = {Context : The literature provides no clear answer as to whether total oestradiol (E2) concentrations increase the risk of incident cardiovascular disease (CVD) in healthy men. 
Objective : The authors conducted a systematic review and meta-analysis to estimate the predictive value of E2 for CVD, and to identify study features explaining conflicting results. 
Data sources : Articles were identified by a Medline and Embase search and citation tracking. 
Study selection : Eligible articles were prospective population-based cohorts and nested case-control studies on E2 and incident cardiovascular disease (CVD), including myocardial infarction, stroke or death from coronary heart disease. 
Data-extraction : Independent researchers re-expressed associations of E2 and incident CVD in a uniform manner to be used in meta-regression analyses for identification of study features explaining conflicting results, and to estimate the predictive value of E2 for CVD. 
Results and conclusions : 14 studies out of 128 electronically identified articles were eligible. Data to be used for meta-analysis could be calculated in seven cases, and in the remaining seven cases, data of three more became available by contacting those authors. Overall, a non-significant association was found with an estimated summary RR of 0.98 for a change of {\textrangle}75th versus {\textlangle}25th percentile in E2 (95\% CI 0.74 to 1.31). Mean body mass index (BMI) of the study population (beta s -0.8, p{\textlangle}0.004), and quality of E2 assay (beta s -0.6, p{\textlangle}0.08) may have modified the relationship between E2 and incident CVD. The present systematic review does not provide evidence for a pronounced harmful or beneficial effect of E2 on risk for incident CVD in healthy men. If present, an effect of E2 on risk for CVD might be modulated by BMI.},
  author       = {VANDENPLAS, GUY and De Bacquer, Dirk and Calders, Patrick and FIERS, TOM and Kaufman, Jean and Ouwens, D Margriet and Ruige, Johannes},
  issn         = {1355-6037},
  journal      = {HEART},
  keyword      = {ELDERLY SWEDISH MEN,MIDDLE-AGED MEN,LOW SERUM TESTOSTERONE,CORONARY-ARTERY-DISEASE,SEX-HORMONES,HEART-DISEASE,CAROTID ATHEROSCLEROSIS,MYOCARDIAL-INFARCTION,RISK-FACTORS,MORTALITY},
  language     = {eng},
  number       = {20},
  pages        = {1478--1482},
  title        = {Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies},
  url          = {http://dx.doi.org/10.1136/heartjnl-2011-301587},
  volume       = {98},
  year         = {2012},
}

Chicago
VANDENPLAS, GUY, Dirk De Bacquer, Patrick Calders, TOM FIERS, Jean Kaufman, D Margriet Ouwens, and Johannes Ruige. 2012. “Endogenous Oestradiol and Cardiovascular Disease in Healthy Men: a Systematic Review and Meta-analysis of Prospective Studies.” Heart 98 (20): 1478–1482.
APA
VANDENPLAS, G., De Bacquer, D., Calders, P., FIERS, T., Kaufman, J., Ouwens, D. M., & Ruige, J. (2012). Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies. HEART, 98(20), 1478–1482.
Vancouver
1.
VANDENPLAS G, De Bacquer D, Calders P, FIERS T, Kaufman J, Ouwens DM, et al. Endogenous oestradiol and cardiovascular disease in healthy men: a systematic review and meta-analysis of prospective studies. HEART. 2012;98(20):1478–82.
MLA
VANDENPLAS, GUY, Dirk De Bacquer, Patrick Calders, et al. “Endogenous Oestradiol and Cardiovascular Disease in Healthy Men: a Systematic Review and Meta-analysis of Prospective Studies.” HEART 98.20 (2012): 1478–1482. Print.