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Effectiveness of rotavirus vaccination in prevention of hospital admissions for rotavirus gastroenteritis among young children in Belgium : case-control study

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Abstract
Objective : To evaluate the effectiveness of rotavirus vaccination among young children in Belgium. Design : Prospective case-control study. Setting : Random sample of 39 Belgian hospitals, February 2008 to June 2010. Participants : 215 children admitted to hospital with rotavirus gastroenteritis confirmed by polymerase chain reaction and 276 age and hospital matched controls. All children were of an eligible age to have received rotavirus vaccination (that is, born after 1 October 2006 and aged >= 14 weeks). Main outcome measure : Vaccination status of children admitted to hospital with rotavirus gastroenteritis and matched controls. Results : 99 children (48%) admitted with rotavirus gastroenteritis and 244 (91%) controls had received at least one dose of any rotavirus vaccine (P<0.001). The monovalent rotavirus vaccine accounted for 92% (n=594) of all rotavirus vaccine doses. With hospital admission as the outcome, the unadjusted effectiveness of two doses of the monovalent rotavirus vaccine was 90% (95% confidence interval 81% to 95%) overall, 91% (75% to 97%) in children aged 3-11 months, and 90% (76% to 96%) in those aged >= 12 months. The G2P[4] genotype accounted for 52% of cases confirmed by polymerase chain reaction with eligible matched controls. Vaccine effectiveness was 85% (64% to 94%) against G2P[4] and 95% (78% to 99%) against G1P[8]. In 25% of cases confirmed by polymerase chain reaction with eligible matched controls, there was reported co-infection with adenovirus, astrovirus and/or norovirus. Vaccine effectiveness against co-infected cases was 86% (52% to 96%). Effectiveness of at least one dose of any rotavirus vaccine (intention to vaccinate analysis) was 91% (82% to 95%). Conclusions : Rotavirus vaccination is effective for the prevention of admission to hospital for rotavirus gastroenteritis among young children in Belgium, despite the high prevalence of G2P[4] and viral co-infection.
Keywords
DISEASE, DOUBLE-BLIND, UNITED-STATES, 1ST 2 YEARS, DIARRHEA-ASSOCIATED HOSPITALIZATIONS, EFFICACY, INFANTS, BURDEN, REDUCTION, AUSTRALIA

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Chicago
Braeckman, Tessa, Koen Van Herck, Nadia Meyer, Jean-Yves Pirçon, Montse Soriano-Gabarró, Elisabeth Heylen, Mark Zeller, et al. 2012. “Effectiveness of Rotavirus Vaccination in Prevention of Hospital Admissions for Rotavirus Gastroenteritis Among Young Children in Belgium : Case-control Study.” British Medical Journal 345.
APA
Braeckman, Tessa, Van Herck, K., Meyer, N., Pirçon, J.-Y., Soriano-Gabarró, M., Heylen, E., Zeller, M., et al. (2012). Effectiveness of rotavirus vaccination in prevention of hospital admissions for rotavirus gastroenteritis among young children in Belgium : case-control study. BRITISH MEDICAL JOURNAL, 345.
Vancouver
1.
Braeckman T, Van Herck K, Meyer N, Pirçon J-Y, Soriano-Gabarró M, Heylen E, et al. Effectiveness of rotavirus vaccination in prevention of hospital admissions for rotavirus gastroenteritis among young children in Belgium : case-control study. BRITISH MEDICAL JOURNAL. 2012;345.
MLA
Braeckman, Tessa, Koen Van Herck, Nadia Meyer, et al. “Effectiveness of Rotavirus Vaccination in Prevention of Hospital Admissions for Rotavirus Gastroenteritis Among Young Children in Belgium : Case-control Study.” BRITISH MEDICAL JOURNAL 345 (2012): n. pag. Print.
@article{3053133,
  abstract     = {Objective : To evaluate the effectiveness of rotavirus vaccination among young children in Belgium. 
Design : Prospective case-control study. 
Setting : Random sample of 39 Belgian hospitals, February 2008 to June 2010. 
Participants : 215 children admitted to hospital with rotavirus gastroenteritis confirmed by polymerase chain reaction and 276 age and hospital matched controls. All children were of an eligible age to have received rotavirus vaccination (that is, born after 1 October 2006 and aged {\textrangle}= 14 weeks). 
Main outcome measure : Vaccination status of children admitted to hospital with rotavirus gastroenteritis and matched controls. 
Results : 99 children (48\%) admitted with rotavirus gastroenteritis and 244 (91\%) controls had received at least one dose of any rotavirus vaccine (P{\textlangle}0.001). The monovalent rotavirus vaccine accounted for 92\% (n=594) of all rotavirus vaccine doses. With hospital admission as the outcome, the unadjusted effectiveness of two doses of the monovalent rotavirus vaccine was 90\% (95\% confidence interval 81\% to 95\%) overall, 91\% (75\% to 97\%) in children aged 3-11 months, and 90\% (76\% to 96\%) in those aged {\textrangle}= 12 months. The G2P[4] genotype accounted for 52\% of cases confirmed by polymerase chain reaction with eligible matched controls. Vaccine effectiveness was 85\% (64\% to 94\%) against G2P[4] and 95\% (78\% to 99\%) against G1P[8]. In 25\% of cases confirmed by polymerase chain reaction with eligible matched controls, there was reported co-infection with adenovirus, astrovirus and/or norovirus. Vaccine effectiveness against co-infected cases was 86\% (52\% to 96\%). Effectiveness of at least one dose of any rotavirus vaccine (intention to vaccinate analysis) was 91\% (82\% to 95\%). 
Conclusions : Rotavirus vaccination is effective for the prevention of admission to hospital for rotavirus gastroenteritis among young children in Belgium, despite the high prevalence of G2P[4] and viral co-infection.},
  articleno    = {e4752},
  author       = {Braeckman, Tessa and Van Herck, Koen and Meyer, Nadia and Pir\c{c}on, Jean-Yves and Soriano-Gabarr{\'o}, Montse and Heylen, Elisabeth and Zeller, Mark and Azou, Myriam and Capiau, Heidi and De Koster, Jan and Maernoudt, Anne-Sophie and Raes, Marc and Verdonck, Lutgard and Verghote, Marc and Vergison, Anne and Matthijnssens, Jelle and Van Ranst, Marc and Van Damme, Pierre},
  issn         = {1756-1833},
  journal      = {BRITISH MEDICAL JOURNAL},
  keyword      = {DISEASE,DOUBLE-BLIND,UNITED-STATES,1ST 2 YEARS,DIARRHEA-ASSOCIATED HOSPITALIZATIONS,EFFICACY,INFANTS,BURDEN,REDUCTION,AUSTRALIA},
  language     = {eng},
  pages        = {13},
  title        = {Effectiveness of rotavirus vaccination in prevention of hospital admissions for rotavirus gastroenteritis among young children in Belgium : case-control study},
  url          = {http://dx.doi.org/10.1136/bmj.e4752},
  volume       = {345},
  year         = {2012},
}

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