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A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability for homogeneous perfusion

Charlotte Debbaut UGent, Jan Vierendeels UGent, Jennifer H Siggers, Rodolfo Repetto, Diethard Monbaliu and Patrick Segers UGent (2014) COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING. 17(12). p.1295-1310
abstract
The hepatic blood circulation is complex, particularly at the microcirculatory level. Previously, 2D liver lobule models using porous media and a 3D model using real sinusoidal geometries have been developed. We extended these models to investigate the role of vascular septa (VS) and anisotropic permeability. The lobule was modelled as a hexagonal prism (with or without VS) and the tissue was treated as a porous medium (isotropic or anisotropic permeability). Models were solved using computational fluid dynamics. VS inclusion resulted in more spatially homogeneous perfusion. Anisotropic permeability resulted in a larger axial velocity component than isotropic permeability. A parameter study revealed that results are most sensitive to the lobule size and radial pressure drop. Our model provides insight into hepatic microhaemodynamics, and suggests that inclusion of VS in the model leads to perfusion patterns that are likely to reflect physiological reality. The model has potential for applications to unphysiological and pathological conditions.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
vascular septa, liver lobule, hepatic microcirculation, computational fluid dynamics, porous medium, anisotropic permeability, HYPOTHERMIC MACHINE PERFUSION, PORCINE LIVERS, HEPATIC LOBULE, TRANSPLANTATION, MICROCIRCULATION, REGENERATION, PRESERVATION, PRESSURE, ARTERIAL, GRAFT
journal title
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
Comput. Methods Biomech. Biomed. Eng.
volume
17
issue
12
pages
1295 - 1310
Web of Science type
Article
Web of Science id
000334487900002
ISSN
1025-5842
DOI
10.1080/10255842.2012.744399
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3052790
handle
http://hdl.handle.net/1854/LU-3052790
date created
2012-11-14 11:30:47
date last changed
2015-08-20 11:32:41
@article{3052790,
  abstract     = {The hepatic blood circulation is complex, particularly at the microcirculatory level. Previously, 2D liver lobule models using porous media and a 3D model using real sinusoidal geometries have been developed. We extended these models to investigate the role of vascular septa (VS) and anisotropic permeability. The lobule was modelled as a hexagonal prism (with or without VS) and the tissue was treated as a porous medium (isotropic or anisotropic permeability). Models were solved using computational fluid dynamics. VS inclusion resulted in more spatially homogeneous perfusion. Anisotropic permeability resulted in a larger axial velocity component than isotropic permeability. A parameter study revealed that results are most sensitive to the lobule size and radial pressure drop. Our model provides insight into hepatic microhaemodynamics, and suggests that inclusion of VS in the model leads to perfusion patterns that are likely to reflect physiological reality. The model has potential for applications to unphysiological and pathological conditions.},
  author       = {Debbaut, Charlotte and Vierendeels, Jan and Siggers, Jennifer H and Repetto, Rodolfo and Monbaliu, Diethard and Segers, Patrick},
  issn         = {1025-5842},
  journal      = {COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING},
  keyword      = {vascular septa,liver lobule,hepatic microcirculation,computational fluid dynamics,porous medium,anisotropic permeability,HYPOTHERMIC MACHINE PERFUSION,PORCINE LIVERS,HEPATIC LOBULE,TRANSPLANTATION,MICROCIRCULATION,REGENERATION,PRESERVATION,PRESSURE,ARTERIAL,GRAFT},
  language     = {eng},
  number       = {12},
  pages        = {1295--1310},
  title        = {A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability for homogeneous perfusion},
  url          = {http://dx.doi.org/10.1080/10255842.2012.744399},
  volume       = {17},
  year         = {2014},
}

Chicago
Debbaut, Charlotte, Jan Vierendeels, Jennifer H Siggers, Rodolfo Repetto, Diethard Monbaliu, and Patrick Segers. 2014. “A 3D Porous Media Liver Lobule Model: The Importance of Vascular Septa and Anisotropic Permeability for Homogeneous Perfusion.” Computer Methods in Biomechanics and Biomedical Engineering 17 (12): 1295–1310.
APA
Debbaut, C., Vierendeels, J., Siggers, J. H., Repetto, R., Monbaliu, D., & Segers, P. (2014). A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability for homogeneous perfusion. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, 17(12), 1295–1310.
Vancouver
1.
Debbaut C, Vierendeels J, Siggers JH, Repetto R, Monbaliu D, Segers P. A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability for homogeneous perfusion. COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING. 2014;17(12):1295–310.
MLA
Debbaut, Charlotte, Jan Vierendeels, Jennifer H Siggers, et al. “A 3D Porous Media Liver Lobule Model: The Importance of Vascular Septa and Anisotropic Permeability for Homogeneous Perfusion.” COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING 17.12 (2014): 1295–1310. Print.