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Towards a human proteomics atlas

Giulia Gonnelli (UGent) , Niels Hulstaert (UGent) , Sven Degroeve (UGent) and Lennart Martens (UGent)
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Abstract
Proteomics research has taken up an increasingly important role in life sciences over the past few years. Due to a strong push from publishers and funders alike, the community has also started to freely share its data in earnest, making use of public repositories such as the highly popular PRIDE database at EMBL-EBI. Reuse of these publicly available data has so far been confined to rather specific, targeted reanalyses, but this limited reuse is set to expand dramatically as repositories continue to grow exponentially. Examples of large-scale reuse are readily found in other omics disciplines, where more comprehensive public data have already accumulated over longer periods. Here, a typical example of integrative data reuse is provided by the construction of so-called expression atlases. We here therefore investigate the issues involved in using the human data currently stored in the PRIDE database to construct a robust, tissue-specific protein expression atlas from tandem-MS based label-free quantification.
Keywords
PEPTIDE, SYSTEM, PROFILES, DISCOVERY, MICROARRAY, DATABASE, UPDATE, PROTEIN QUANTIFICATION, MASS-SPECTROMETRY, GENE-EXPRESSION ATLAS, Quantification, Mass spectrometry, Bioinformatics, Proteomics

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MLA
Gonnelli, Giulia, et al. “Towards a Human Proteomics Atlas.” ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 404, no. 4, 2012, pp. 1069–77, doi:10.1007/s00216-012-5940-8.
APA
Gonnelli, G., Hulstaert, N., Degroeve, S., & Martens, L. (2012). Towards a human proteomics atlas. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 404(4), 1069–1077. https://doi.org/10.1007/s00216-012-5940-8
Chicago author-date
Gonnelli, Giulia, Niels Hulstaert, Sven Degroeve, and Lennart Martens. 2012. “Towards a Human Proteomics Atlas.” ANALYTICAL AND BIOANALYTICAL CHEMISTRY 404 (4): 1069–77. https://doi.org/10.1007/s00216-012-5940-8.
Chicago author-date (all authors)
Gonnelli, Giulia, Niels Hulstaert, Sven Degroeve, and Lennart Martens. 2012. “Towards a Human Proteomics Atlas.” ANALYTICAL AND BIOANALYTICAL CHEMISTRY 404 (4): 1069–1077. doi:10.1007/s00216-012-5940-8.
Vancouver
1.
Gonnelli G, Hulstaert N, Degroeve S, Martens L. Towards a human proteomics atlas. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2012;404(4):1069–77.
IEEE
[1]
G. Gonnelli, N. Hulstaert, S. Degroeve, and L. Martens, “Towards a human proteomics atlas,” ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 404, no. 4, pp. 1069–1077, 2012.
@article{3049757,
  abstract     = {{Proteomics research has taken up an increasingly important role in life sciences over the past few years. Due to a strong push from publishers and funders alike, the community has also started to freely share its data in earnest, making use of public repositories such as the highly popular PRIDE database at EMBL-EBI. Reuse of these publicly available data has so far been confined to rather specific, targeted reanalyses, but this limited reuse is set to expand dramatically as repositories continue to grow exponentially. Examples of large-scale reuse are readily found in other omics disciplines, where more comprehensive public data have already accumulated over longer periods. Here, a typical example of integrative data reuse is provided by the construction of so-called expression atlases. We here therefore investigate the issues involved in using the human data currently stored in the PRIDE database to construct a robust, tissue-specific protein expression atlas from tandem-MS based label-free quantification.}},
  author       = {{Gonnelli, Giulia and Hulstaert, Niels and Degroeve, Sven and Martens, Lennart}},
  issn         = {{1618-2642}},
  journal      = {{ANALYTICAL AND BIOANALYTICAL CHEMISTRY}},
  keywords     = {{PEPTIDE,SYSTEM,PROFILES,DISCOVERY,MICROARRAY,DATABASE,UPDATE,PROTEIN QUANTIFICATION,MASS-SPECTROMETRY,GENE-EXPRESSION ATLAS,Quantification,Mass spectrometry,Bioinformatics,Proteomics}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1069--1077}},
  title        = {{Towards a human proteomics atlas}},
  url          = {{http://doi.org/10.1007/s00216-012-5940-8}},
  volume       = {{404}},
  year         = {{2012}},
}

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