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ER stress-induced inflammation: does it aid or impede disease progression?

Abhishek Garg, Agnieszka Kaczmarek UGent, Olga Krysko UGent, Peter Vandenabeele UGent, Dmitri Krysko UGent and Patrizia Agostinis (2012) TRENDS IN MOLECULAR MEDICINE. 18(10). p.589-598
abstract
Different lines of research have revealed that pathways activated by the endoplasmic reticulum (ER) stress response induce sterile inflammation. When activated, all three sensors of the unfolded protein response (UPR), PERK, IRE1, and ATF6, participate in upregulating inflammatory processes. ER stress in various cells plays an important role in the pathogenesis of several diseases, including obesity, type 2 diabetes, cancer, and intestinal bowel and airway diseases. Moreover, it has been suggested that ER stress-induced inflammation contributes substantially to disease progression. However, this generalization can be challenged at least in the case of cancer. In this review, we emphasize that ER stress can either aid or impede disease progression via inflammatory pathways depending on the cell type, disease stage, and type of ER stressor.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
TUMOR-NECROSIS-FACTOR, UNFOLDED PROTEIN RESPONSE, ACUTE-PHASE RESPONSE, OBSTRUCTIVE PULMONARY-DISEASE, INTESTINAL EPITHELIAL-CELLS, INSULIN-RESISTANCE, CYSTIC-FIBROSIS, CIGARETTE-SMOKE, NF-KAPPA-B, ENDOPLASMIC-RETICULUM STRESS, airway disease, therapeutics, immunity, inflammatory bowel disease, ER stress, cancer, inflammation, obesity, diabetes
journal title
TRENDS IN MOLECULAR MEDICINE
Trends Mol. Med.
volume
18
issue
10
pages
589 - 598
Web of Science type
Review
Web of Science id
000310387800004
JCR category
MEDICINE, RESEARCH & EXPERIMENTAL
JCR impact factor
9.571 (2012)
JCR rank
7/119 (2012)
JCR quartile
1 (2012)
ISSN
1471-4914
DOI
10.1016/j.molmed.2012.06.010
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3039707
handle
http://hdl.handle.net/1854/LU-3039707
date created
2012-10-31 14:30:56
date last changed
2014-05-12 11:01:38
@article{3039707,
  abstract     = {Different lines of research have revealed that pathways activated by the endoplasmic reticulum (ER) stress response induce sterile inflammation. When activated, all three sensors of the unfolded protein response (UPR), PERK, IRE1, and ATF6, participate in upregulating inflammatory processes. ER stress in various cells plays an important role in the pathogenesis of several diseases, including obesity, type 2 diabetes, cancer, and intestinal bowel and airway diseases. Moreover, it has been suggested that ER stress-induced inflammation contributes substantially to disease progression. However, this generalization can be challenged at least in the case of cancer. In this review, we emphasize that ER stress can either aid or impede disease progression via inflammatory pathways depending on the cell type, disease stage, and type of ER stressor.},
  author       = {Garg, Abhishek and Kaczmarek, Agnieszka and Krysko, Olga and Vandenabeele, Peter and Krysko, Dmitri and Agostinis, Patrizia},
  issn         = {1471-4914},
  journal      = {TRENDS IN MOLECULAR MEDICINE},
  keyword      = {TUMOR-NECROSIS-FACTOR,UNFOLDED PROTEIN RESPONSE,ACUTE-PHASE RESPONSE,OBSTRUCTIVE PULMONARY-DISEASE,INTESTINAL EPITHELIAL-CELLS,INSULIN-RESISTANCE,CYSTIC-FIBROSIS,CIGARETTE-SMOKE,NF-KAPPA-B,ENDOPLASMIC-RETICULUM STRESS,airway disease,therapeutics,immunity,inflammatory bowel disease,ER stress,cancer,inflammation,obesity,diabetes},
  language     = {eng},
  number       = {10},
  pages        = {589--598},
  title        = {ER stress-induced inflammation: does it aid or impede disease progression?},
  url          = {http://dx.doi.org/10.1016/j.molmed.2012.06.010},
  volume       = {18},
  year         = {2012},
}

Chicago
Garg, Abhishek, Agnieszka Kaczmarek, Olga Krysko, Peter Vandenabeele, Dmitri Krysko, and Patrizia Agostinis. 2012. “ER Stress-induced Inflammation: Does It Aid or Impede Disease Progression?” Trends in Molecular Medicine 18 (10): 589–598.
APA
Garg, Abhishek, Kaczmarek, A., Krysko, O., Vandenabeele, P., Krysko, D., & Agostinis, P. (2012). ER stress-induced inflammation: does it aid or impede disease progression? TRENDS IN MOLECULAR MEDICINE, 18(10), 589–598.
Vancouver
1.
Garg A, Kaczmarek A, Krysko O, Vandenabeele P, Krysko D, Agostinis P. ER stress-induced inflammation: does it aid or impede disease progression? TRENDS IN MOLECULAR MEDICINE. 2012;18(10):589–98.
MLA
Garg, Abhishek, Agnieszka Kaczmarek, Olga Krysko, et al. “ER Stress-induced Inflammation: Does It Aid or Impede Disease Progression?” TRENDS IN MOLECULAR MEDICINE 18.10 (2012): 589–598. Print.