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Contribution of ER stress to immunogenic cancer cell death

Abhishek D Garg, Dmitri Krysko UGent, Jakub Golab, Peter Vandenabeele UGent and Patrizia Agostinis (2012) Endoplasmic reticulum stress in health and disease. p.413-428
abstract
ER stress-induced inflammation is a complex phenomenon which can have either disease-supporting or disease-controlling effects depending on the pathology of the particular disease in focus. In case of cancer it has been observed that ER stress-induced inflammation can have both pro-tumorigenic as well as anti-tumorigenic roles. Thus, therapeutic strategies that can tilt the balance towards anti-tumorigenic role might be our best bet. It has been suggested that therapeutically induced reactive oxygen species (ROS)-based ER stress could instigate within the cancer cells, danger signaling pathways that lead to ‘emission’ of certain damage-associated molecular patterns (DAMPs). These molecules could ultimately cause ‘immunogenic apoptosis,’ a cell death modality that can revive anti-tumor immunity. These new findings point to the importance of therapeutically targeting ER stress-induced inflammation in cancer. In the current chapter we discuss the prospects of inducing ER stress-induced inflammation that supports anti-tumor immunity.
Please use this url to cite or link to this publication:
author
organization
year
type
bookChapter
publication status
published
subject
keyword
immunogenic cell death, DAMPs, ER stress
book title
Endoplasmic reticulum stress in health and disease
editor
Patrizia Agosnitis and Afshin Samali UGent
pages
413 - 428
publisher
Springer
place of publication
Dordrecht, The Netherlands
ISBN
9789400743502
9789400743519
DOI
10.1007/978-94-007-4351-9_18
language
English
UGent publication?
yes
classification
B2
copyright statement
I have transferred the copyright for this publication to the publisher
VABB id
c:vabb:339874
VABB type
VABB-4
id
3039464
handle
http://hdl.handle.net/1854/LU-3039464
date created
2012-10-31 13:26:03
date last changed
2015-06-17 10:17:47
@incollection{3039464,
  abstract     = {ER stress-induced inflammation is a complex phenomenon which can have either disease-supporting or disease-controlling effects depending on the pathology of the particular disease in focus. In case of cancer it has been observed that ER stress-induced inflammation can have both pro-tumorigenic as well as anti-tumorigenic roles. Thus, therapeutic strategies that can tilt the balance towards anti-tumorigenic role might be our best bet. It has been suggested that therapeutically induced reactive oxygen species (ROS)-based ER stress could instigate within the cancer cells, danger signaling pathways that lead to {\textquoteleft}emission{\textquoteright} of certain damage-associated molecular patterns (DAMPs). These molecules could ultimately cause {\textquoteleft}immunogenic apoptosis,{\textquoteright} a cell death modality that can revive anti-tumor immunity. These new findings point to the importance of therapeutically targeting ER stress-induced inflammation in cancer. In the current chapter we discuss the prospects of inducing ER stress-induced inflammation that supports anti-tumor immunity.},
  author       = {Garg, Abhishek D and Krysko, Dmitri and Golab, Jakub  and Vandenabeele, Peter and Agostinis, Patrizia},
  booktitle    = {Endoplasmic reticulum stress in health and disease},
  editor       = {Agosnitis, Patrizia and Samali, Afshin},
  isbn         = {9789400743502},
  keyword      = {immunogenic cell death,DAMPs,ER stress},
  language     = {eng},
  pages        = {413--428},
  publisher    = {Springer},
  title        = {Contribution of ER stress to immunogenic cancer cell death},
  url          = {http://dx.doi.org/10.1007/978-94-007-4351-9\_18},
  year         = {2012},
}

Chicago
Garg, Abhishek D, Dmitri Krysko, Jakub Golab, Peter Vandenabeele, and Patrizia Agostinis. 2012. “Contribution of ER Stress to Immunogenic Cancer Cell Death.” In Endoplasmic Reticulum Stress in Health and Disease, ed. Patrizia Agosnitis and Afshin Samali, 413–428. Dordrecht, The Netherlands: Springer.
APA
Garg, Abhishek D, Krysko, D., Golab, J., Vandenabeele, P., & Agostinis, P. (2012). Contribution of ER stress to immunogenic cancer cell death. In P. Agosnitis & A. Samali (Eds.), Endoplasmic reticulum stress in health and disease (pp. 413–428). Dordrecht, The Netherlands: Springer.
Vancouver
1.
Garg AD, Krysko D, Golab J, Vandenabeele P, Agostinis P. Contribution of ER stress to immunogenic cancer cell death. In: Agosnitis P, Samali A, editors. Endoplasmic reticulum stress in health and disease. Dordrecht, The Netherlands: Springer; 2012. p. 413–28.
MLA
Garg, Abhishek D, Dmitri Krysko, Jakub Golab, et al. “Contribution of ER Stress to Immunogenic Cancer Cell Death.” Endoplasmic Reticulum Stress in Health and Disease. Ed. Patrizia Agosnitis & Afshin Samali. Dordrecht, The Netherlands: Springer, 2012. 413–428. Print.