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ER stress and inflammation

Abhsihek D Garg, Agnieszka Kaczmarek UGent, Dmitri Krysko UGent and Peter Vandenabeele UGent (2012) Endoplasmic reticulum stress in health and disease. p.257-279
abstract
Accumulating evidence indicates that ER-stress-activated pathways, e.g. the unfolded protein response (UPR), lead to activation of various inflammatory processes, such as the acute-phase response (APR) and those instigated by transcriptional factors like NF-κB and AP-1. ER stress-mediated inflammation has been found to be associated with several diseases, such as obesity, type 2 diabetes, intestinal bowel disease and cancer. The role of ER stress-mediated inflammation is not straightforward as it can vary from disease-promoting/supporting to disease-controlling depending upon the cell type or disease in focus. This makes therapeutic targeting of ER stress-mediated inflammation very challenging and tough. In this chapter, we discuss the biology of ER stress-induced inflammation, its role in various diseases, and the possibility of targeting it for therapeutic purposes.
Please use this url to cite or link to this publication:
author
organization
year
type
bookChapter
publication status
published
subject
book title
Endoplasmic reticulum stress in health and disease
editor
Patrizia Agostinis and Afshin Samali UGent
pages
257 - 279
publisher
Springer
place of publication
Dordrecht, The Netherlands
ISBN
9789400743502
9789400743519
DOI
10.1007/978-94-007-4351-9_11
language
English
UGent publication?
yes
classification
B2
copyright statement
I have transferred the copyright for this publication to the publisher
VABB id
c:vabb:339873
VABB type
VABB-4
id
3039441
handle
http://hdl.handle.net/1854/LU-3039441
date created
2012-10-31 13:10:02
date last changed
2015-06-17 10:17:46
@incollection{3039441,
  abstract     = {Accumulating evidence indicates that ER-stress-activated pathways, e.g. the unfolded protein response (UPR), lead to activation of various inflammatory processes, such as the acute-phase response (APR) and those instigated by transcriptional factors like NF-\ensuremath{\kappa}B and AP-1. ER stress-mediated inflammation has been found to be associated with several diseases, such as obesity, type 2 diabetes, intestinal bowel disease and cancer. The role of ER stress-mediated inflammation is not straightforward as it can vary from disease-promoting/supporting to disease-controlling depending upon the cell type or disease in focus. This makes therapeutic targeting of ER stress-mediated inflammation very challenging and tough. In this chapter, we discuss the biology of ER stress-induced inflammation, its role in various diseases, and the possibility of targeting it for therapeutic purposes.},
  author       = {Garg, Abhsihek D and Kaczmarek, Agnieszka and Krysko, Dmitri and Vandenabeele, Peter},
  booktitle    = {Endoplasmic reticulum stress in health and disease},
  editor       = {Agostinis, Patrizia and Samali, Afshin},
  isbn         = {9789400743502},
  language     = {eng},
  pages        = {257--279},
  publisher    = {Springer},
  title        = {ER stress and inflammation},
  url          = {http://dx.doi.org/10.1007/978-94-007-4351-9\_11},
  year         = {2012},
}

Chicago
Garg, Abhsihek D, Agnieszka Kaczmarek, Dmitri Krysko, and Peter Vandenabeele. 2012. “ER Stress and Inflammation.” In Endoplasmic Reticulum Stress in Health and Disease, ed. Patrizia Agostinis and Afshin Samali, 257–279. Dordrecht, The Netherlands: Springer.
APA
Garg, Abhsihek D, Kaczmarek, A., Krysko, D., & Vandenabeele, P. (2012). ER stress and inflammation. In P. Agostinis & A. Samali (Eds.), Endoplasmic reticulum stress in health and disease (pp. 257–279). Dordrecht, The Netherlands: Springer.
Vancouver
1.
Garg AD, Kaczmarek A, Krysko D, Vandenabeele P. ER stress and inflammation. In: Agostinis P, Samali A, editors. Endoplasmic reticulum stress in health and disease. Dordrecht, The Netherlands: Springer; 2012. p. 257–79.
MLA
Garg, Abhsihek D, Agnieszka Kaczmarek, Dmitri Krysko, et al. “ER Stress and Inflammation.” Endoplasmic Reticulum Stress in Health and Disease. Ed. Patrizia Agostinis & Afshin Samali. Dordrecht, The Netherlands: Springer, 2012. 257–279. Print.