Ghent University Academic Bibliography

Advanced

Population-level retrospective study of neurologically expressed disorders in ruminants before the onset of bovine spongiform encephalopathy (BSE) in Belgium, a BSE risk III country

C Saegerman, Dirk Berkvens UGent, L Claes, A Dewaele, F Coignoul, Richard Ducatelle UGent, D Cassart, B Brochier, F Costy, S Roels, et al. (2005) JOURNAL OF CLINICAL MICROBIOLOGY. 43(2). p.862-869
abstract
A retrospective epidemiological study (n = 7,875) of neurologically expressed disorders (NED) in ruminants before the onset of the bovine spongiform encephalopathy epidemic (years studied, 1980 to 1997) was carried out in Belgium. The archives of all veterinary laboratories and rabies and transmissible spongiform encephalopathy (TSE) epidetniosurveillance networks were consulted. For all species, a significantly higher number of NED with virological causes (rabies) was reported south of the Sambre-Meuse Valley. During the period 1992 to 1997, for which the data were complete, (i) the predicted annual incidence of NED varied significantly as a function of species and area (higher numbers in areas where rabies was present) but was always above 100 cases per million, and (ii) the mean incidence of suspected TSE cases and, among them, those investigated by histopathological examination varied significantly as a function of species and area. The positive predictive value of a presumptive clinical diagnosis of NED ranged from 0.13 (game) to 0.63 (sheep). Knowledge of the positive predictive value permits the definition of a reference point before certain actions (e.g., awareness and training campaigns) are undertaken. It also shows the usefulness of a systematic necropsy or complementary laboratory tests to establish an etiological diagnosis. TSE analysis of a small, targeted historical sampling (n = 48) permitted the confirmation of one case and uncovered another case of scrapie. The results of the present study help to develop and maintain the quality of the worldwide clinical epidemiological networks for TSE, especially in countries that in the past imported live animals, animal products, and feedstuffs from countries with TSE cases.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CLINICAL SIGNS, DIFFERENTIAL-DIAGNOSIS, SWITZERLAND, EPIDEMIOLOGY, DISEASE, TRANSMISSION, SHEEP, CATTLE, SCRAPIE, GREAT-BRITAIN
journal title
JOURNAL OF CLINICAL MICROBIOLOGY
J. Clin. Microbiol.
volume
43
issue
2
pages
862 - 869
Web of Science type
Article
Web of Science id
000227045600053
JCR category
MICROBIOLOGY
JCR impact factor
3.537 (2005)
JCR rank
20/85 (2005)
JCR quartile
1 (2005)
ISSN
0095-1137
DOI
10.1128/JCM.43.2.862-869.2005
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
303324
handle
http://hdl.handle.net/1854/LU-303324
date created
2005-05-03 14:15:00
date last changed
2016-12-19 15:42:15
@article{303324,
  abstract     = {A retrospective epidemiological study (n = 7,875) of neurologically expressed disorders (NED) in ruminants before the onset of the bovine spongiform encephalopathy epidemic (years studied, 1980 to 1997) was carried out in Belgium. The archives of all veterinary laboratories and rabies and transmissible spongiform encephalopathy (TSE) epidetniosurveillance networks were consulted. For all species, a significantly higher number of NED with virological causes (rabies) was reported south of the Sambre-Meuse Valley. During the period 1992 to 1997, for which the data were complete, (i) the predicted annual incidence of NED varied significantly as a function of species and area (higher numbers in areas where rabies was present) but was always above 100 cases per million, and (ii) the mean incidence of suspected TSE cases and, among them, those investigated by histopathological examination varied significantly as a function of species and area. The positive predictive value of a presumptive clinical diagnosis of NED ranged from 0.13 (game) to 0.63 (sheep). Knowledge of the positive predictive value permits the definition of a reference point before certain actions (e.g., awareness and training campaigns) are undertaken. It also shows the usefulness of a systematic necropsy or complementary laboratory tests to establish an etiological diagnosis. TSE analysis of a small, targeted historical sampling (n = 48) permitted the confirmation of one case and uncovered another case of scrapie. The results of the present study help to develop and maintain the quality of the worldwide clinical epidemiological networks for TSE, especially in countries that in the past imported live animals, animal products, and feedstuffs from countries with TSE cases.},
  author       = {Saegerman, C and Berkvens, Dirk and Claes, L and Dewaele, A and Coignoul, F and Ducatelle, Richard and Cassart, D and Brochier, B and Costy, F and Roels, S and Deluyker, H and Vanopdenbosch, E and Thiry, E},
  issn         = {0095-1137},
  journal      = {JOURNAL OF CLINICAL MICROBIOLOGY},
  keyword      = {CLINICAL SIGNS,DIFFERENTIAL-DIAGNOSIS,SWITZERLAND,EPIDEMIOLOGY,DISEASE,TRANSMISSION,SHEEP,CATTLE,SCRAPIE,GREAT-BRITAIN},
  language     = {eng},
  number       = {2},
  pages        = {862--869},
  title        = {Population-level retrospective study of neurologically expressed disorders in ruminants before the onset of bovine spongiform encephalopathy (BSE) in Belgium, a BSE risk III country},
  url          = {http://dx.doi.org/10.1128/JCM.43.2.862-869.2005},
  volume       = {43},
  year         = {2005},
}

Chicago
Saegerman, C, Dirk Berkvens, L Claes, A Dewaele, F Coignoul, Richard Ducatelle, D Cassart, et al. 2005. “Population-level Retrospective Study of Neurologically Expressed Disorders in Ruminants Before the Onset of Bovine Spongiform Encephalopathy (BSE) in Belgium, a BSE Risk III Country.” Journal of Clinical Microbiology 43 (2): 862–869.
APA
Saegerman, C., Berkvens, D., Claes, L., Dewaele, A., Coignoul, F., Ducatelle, R., Cassart, D., et al. (2005). Population-level retrospective study of neurologically expressed disorders in ruminants before the onset of bovine spongiform encephalopathy (BSE) in Belgium, a BSE risk III country. JOURNAL OF CLINICAL MICROBIOLOGY, 43(2), 862–869.
Vancouver
1.
Saegerman C, Berkvens D, Claes L, Dewaele A, Coignoul F, Ducatelle R, et al. Population-level retrospective study of neurologically expressed disorders in ruminants before the onset of bovine spongiform encephalopathy (BSE) in Belgium, a BSE risk III country. JOURNAL OF CLINICAL MICROBIOLOGY. 2005;43(2):862–9.
MLA
Saegerman, C, Dirk Berkvens, L Claes, et al. “Population-level Retrospective Study of Neurologically Expressed Disorders in Ruminants Before the Onset of Bovine Spongiform Encephalopathy (BSE) in Belgium, a BSE Risk III Country.” JOURNAL OF CLINICAL MICROBIOLOGY 43.2 (2005): 862–869. Print.