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Integrating fasciolosis control in the dry cow management: the effect of closantel treatment on milk production

Johannes Charlier UGent, Miel Hostens UGent, Jos Jacobs, Bonny Van Ranst, Luc Duchateau UGent and Jozef Vercruysse UGent (2012) PLOS ONE. 7(8).
abstract
The liver fluke Fasciola hepatica is a parasite of ruminants with a worldwide distribution and an apparent increasing incidence in EU member states. Effective control in dairy cattle is hampered by the lack of flukicides with a zero-withdrawal time for milk, leaving the dry period as the only time that preventive treatment can be applied. Here, we present the results of a blinded, randomized and placebo-controlled trial on 11 dairy herds (402 animals) exposed to F. hepatica to 1) assess the effect of closantel treatment at dry-off (or 80-42 days before calving in first-calving heifers) on milk production parameters and 2) evaluate if a number of easy-to-use animal parameters is related to the milk production response after treatment. Closantel treatment resulted in a noticeable decrease of anti-F. hepatica antibody levels from 3-6 months after treatment onwards, a higher peak production (1.06 kg) and a slightly higher persistence (9%) of the lactation, resulting in a 305-day milk production increase of 303 kg. No effects of anthelmintic treatment were found on the average protein and fat content of the milk. Milk production responses after treatment were poor in meagre animals and clinically relevant higher milk production responses were observed in first-lactation animals and in cows with a high (0.3-0.5 optical density ratio (ODR)), but not a very high (>= 0.5 ODR) F. hepatica ELISA result on a milk sample from the previous lactation. We conclude that in dairy herds exposed to F. hepatica, flukicide treatment at dry-off is a useful strategy to reduce levels of exposure and increase milk production in the subsequent lactation. Moreover, the results suggest that treatment approaches that only target selected animals within a herd can be developed based on easy-to-use parameters.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SEROPREVALENCE, RISK, ASSOCIATION, CATTLE, HERDS, ELISA, LACTATION MODEL, BOVINE FASCIOLIASIS, DAIRY-COWS, HEPATICA ANTIBODY-LEVELS
journal title
PLOS ONE
PLoS One
volume
7
issue
8
article_number
e43216
pages
7 pages
Web of Science type
Article
Web of Science id
000307733800054
JCR category
MULTIDISCIPLINARY SCIENCES
JCR impact factor
3.73 (2012)
JCR rank
7/56 (2012)
JCR quartile
1 (2012)
ISSN
1932-6203
DOI
10.1371/journal.pone.0043216
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
3032894
handle
http://hdl.handle.net/1854/LU-3032894
date created
2012-10-22 16:00:16
date last changed
2012-10-23 10:12:25
@article{3032894,
  abstract     = {The liver fluke Fasciola hepatica is a parasite of ruminants with a worldwide distribution and an apparent increasing incidence in EU member states. Effective control in dairy cattle is hampered by the lack of flukicides with a zero-withdrawal time for milk, leaving the dry period as the only time that preventive treatment can be applied. Here, we present the results of a blinded, randomized and placebo-controlled trial on 11 dairy herds (402 animals) exposed to F. hepatica to 1) assess the effect of closantel treatment at dry-off (or 80-42 days before calving in first-calving heifers) on milk production parameters and 2) evaluate if a number of easy-to-use animal parameters is related to the milk production response after treatment. Closantel treatment resulted in a noticeable decrease of anti-F. hepatica antibody levels from 3-6 months after treatment onwards, a higher peak production (1.06 kg) and a slightly higher persistence (9\%) of the lactation, resulting in a 305-day milk production increase of 303 kg. No effects of anthelmintic treatment were found on the average protein and fat content of the milk. Milk production responses after treatment were poor in meagre animals and clinically relevant higher milk production responses were observed in first-lactation animals and in cows with a high (0.3-0.5 optical density ratio (ODR)), but not a very high ({\textrangle}= 0.5 ODR) F. hepatica ELISA result on a milk sample from the previous lactation. We conclude that in dairy herds exposed to F. hepatica, flukicide treatment at dry-off is a useful strategy to reduce levels of exposure and increase milk production in the subsequent lactation. Moreover, the results suggest that treatment approaches that only target selected animals within a herd can be developed based on easy-to-use parameters.},
  articleno    = {e43216},
  author       = {Charlier, Johannes and Hostens, Miel and Jacobs, Jos and Van Ranst, Bonny and Duchateau, Luc and Vercruysse, Jozef},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {SEROPREVALENCE,RISK,ASSOCIATION,CATTLE,HERDS,ELISA,LACTATION MODEL,BOVINE FASCIOLIASIS,DAIRY-COWS,HEPATICA ANTIBODY-LEVELS},
  language     = {eng},
  number       = {8},
  pages        = {7},
  title        = {Integrating fasciolosis control in the dry cow management: the effect of closantel treatment on milk production},
  url          = {http://dx.doi.org/10.1371/journal.pone.0043216},
  volume       = {7},
  year         = {2012},
}

Chicago
Charlier, Johannes, Miel Hostens, Jos Jacobs, Bonny Van Ranst, Luc Duchateau, and Jozef Vercruysse. 2012. “Integrating Fasciolosis Control in the Dry Cow Management: The Effect of Closantel Treatment on Milk Production.” Plos One 7 (8).
APA
Charlier, J., Hostens, M., Jacobs, J., Van Ranst, B., Duchateau, L., & Vercruysse, J. (2012). Integrating fasciolosis control in the dry cow management: the effect of closantel treatment on milk production. PLOS ONE, 7(8).
Vancouver
1.
Charlier J, Hostens M, Jacobs J, Van Ranst B, Duchateau L, Vercruysse J. Integrating fasciolosis control in the dry cow management: the effect of closantel treatment on milk production. PLOS ONE. 2012;7(8).
MLA
Charlier, Johannes, Miel Hostens, Jos Jacobs, et al. “Integrating Fasciolosis Control in the Dry Cow Management: The Effect of Closantel Treatment on Milk Production.” PLOS ONE 7.8 (2012): n. pag. Print.