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Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces

(2004) CHROMATOGRAPHIA. 59. p.S85-S93
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Abstract
Norchlorotestosterone acetate (NClTA) is an anabolic steroid which resembles chlorotestosterone acetate. It cannot yet be detected by routine methods used for anabolic steroids, because there is no knowledge of its metabolic pathway. The invertebrate Neomysis integer has been used as an alternative model to study the metabolism of NClTA. The experimental results indicated the presence of 4-norchloroandrost-4-ene-17-ol-3-one (NClT) and 4-norchloroandrost-4-ene-3,17-dione (NorClAD) as possible metabolites of NClTA. Subsequently NClTA and the synthesised metabolites NClT and NorClAD were incorporated into the routine multi-residue method for detection of anabolic steroids in kidney fat, urine, and faeces.
Keywords
Neomysis integer, TANDEM MASS-SPECTROMETRY, metabolism, norchlorotestosterone acelate, gas chromatography, mass spectrometry, column liquid chromatography, mass spectrometry, RESIDUES, STEROIDS, IDENTIFICATION, CATTLE, ILLEGAL USE, 4-CHLOROTESTOSTERONE ACETATE

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Chicago
Van Hoof, Nathalie, K De Wasch, Sofie Poelmans, D Bruneel, S Spruyt, Herlinde Noppe, Colin Janssen, D Courtheyn, and Hubert De Brabander. 2004. “Norchlorotestosterone Acetate: An Alternative Metabolism Study and GC-MS2 Analysis in Kidney Fat, Urine, and Faeces.” Chromatographia 59: S85–S93.
APA
Van Hoof, N., De Wasch, K., Poelmans, S., Bruneel, D., Spruyt, S., Noppe, H., Janssen, C., et al. (2004). Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces. CHROMATOGRAPHIA, 59, S85–S93.
Vancouver
1.
Van Hoof N, De Wasch K, Poelmans S, Bruneel D, Spruyt S, Noppe H, et al. Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces. CHROMATOGRAPHIA. 2004;59:S85–S93.
MLA
Van Hoof, Nathalie, K De Wasch, Sofie Poelmans, et al. “Norchlorotestosterone Acetate: An Alternative Metabolism Study and GC-MS2 Analysis in Kidney Fat, Urine, and Faeces.” CHROMATOGRAPHIA 59 (2004): S85–S93. Print.
@article{303244,
  abstract     = {Norchlorotestosterone acetate (NClTA) is an anabolic steroid which resembles chlorotestosterone acetate. It cannot yet be detected by routine methods used for anabolic steroids, because there is no knowledge of its metabolic pathway. The invertebrate Neomysis integer has been used as an alternative model to study the metabolism of NClTA. The experimental results indicated the presence of 4-norchloroandrost-4-ene-17-ol-3-one (NClT) and 4-norchloroandrost-4-ene-3,17-dione (NorClAD) as possible metabolites of NClTA. Subsequently NClTA and the synthesised metabolites NClT and NorClAD were incorporated into the routine multi-residue method for detection of anabolic steroids in kidney fat, urine, and faeces.},
  author       = {Van Hoof, Nathalie and De Wasch, K and Poelmans, Sofie and Bruneel, D and Spruyt, S and Noppe, Herlinde and Janssen, Colin and Courtheyn, D and De Brabander, Hubert},
  issn         = {0009-5893},
  journal      = {CHROMATOGRAPHIA},
  keyword      = {Neomysis integer,TANDEM MASS-SPECTROMETRY,metabolism,norchlorotestosterone acelate,gas chromatography,mass spectrometry,column liquid chromatography,mass spectrometry,RESIDUES,STEROIDS,IDENTIFICATION,CATTLE,ILLEGAL USE,4-CHLOROTESTOSTERONE ACETATE},
  language     = {eng},
  pages        = {S85--S93},
  title        = {Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces},
  url          = {http://dx.doi.org/10.1365/s10337-003-0178-4},
  volume       = {59},
  year         = {2004},
}

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