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Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces

Nathalie Van Hoof, K De Wasch, Sofie Poelmans, D Bruneel, S Spruyt, Herlinde Noppe UGent, Colin Janssen UGent, D Courtheyn and Hubert De Brabander UGent (2004) CHROMATOGRAPHIA. 59. p.S85-S93
abstract
Norchlorotestosterone acetate (NClTA) is an anabolic steroid which resembles chlorotestosterone acetate. It cannot yet be detected by routine methods used for anabolic steroids, because there is no knowledge of its metabolic pathway. The invertebrate Neomysis integer has been used as an alternative model to study the metabolism of NClTA. The experimental results indicated the presence of 4-norchloroandrost-4-ene-17-ol-3-one (NClT) and 4-norchloroandrost-4-ene-3,17-dione (NorClAD) as possible metabolites of NClTA. Subsequently NClTA and the synthesised metabolites NClT and NorClAD were incorporated into the routine multi-residue method for detection of anabolic steroids in kidney fat, urine, and faeces.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Neomysis integer, TANDEM MASS-SPECTROMETRY, metabolism, norchlorotestosterone acelate, gas chromatography, mass spectrometry, column liquid chromatography, mass spectrometry, RESIDUES, STEROIDS, IDENTIFICATION, CATTLE, ILLEGAL USE, 4-CHLOROTESTOSTERONE ACETATE
journal title
CHROMATOGRAPHIA
Chromatographia
volume
59
pages
S85 - S93
Web of Science type
Article
Web of Science id
000224155600012
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
1.145 (2004)
JCR rank
42/70 (2004)
JCR quartile
3 (2004)
ISSN
0009-5893
DOI
10.1365/s10337-003-0178-4
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
303244
handle
http://hdl.handle.net/1854/LU-303244
date created
2005-05-03 12:28:00
date last changed
2016-12-19 15:43:54
@article{303244,
  abstract     = {Norchlorotestosterone acetate (NClTA) is an anabolic steroid which resembles chlorotestosterone acetate. It cannot yet be detected by routine methods used for anabolic steroids, because there is no knowledge of its metabolic pathway. The invertebrate Neomysis integer has been used as an alternative model to study the metabolism of NClTA. The experimental results indicated the presence of 4-norchloroandrost-4-ene-17-ol-3-one (NClT) and 4-norchloroandrost-4-ene-3,17-dione (NorClAD) as possible metabolites of NClTA. Subsequently NClTA and the synthesised metabolites NClT and NorClAD were incorporated into the routine multi-residue method for detection of anabolic steroids in kidney fat, urine, and faeces.},
  author       = {Van Hoof, Nathalie and De Wasch, K and Poelmans, Sofie and Bruneel, D and Spruyt, S and Noppe, Herlinde and Janssen, Colin and Courtheyn, D and De Brabander, Hubert},
  issn         = {0009-5893},
  journal      = {CHROMATOGRAPHIA},
  keyword      = {Neomysis integer,TANDEM MASS-SPECTROMETRY,metabolism,norchlorotestosterone acelate,gas chromatography,mass spectrometry,column liquid chromatography,mass spectrometry,RESIDUES,STEROIDS,IDENTIFICATION,CATTLE,ILLEGAL USE,4-CHLOROTESTOSTERONE ACETATE},
  language     = {eng},
  pages        = {S85--S93},
  title        = {Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces},
  url          = {http://dx.doi.org/10.1365/s10337-003-0178-4},
  volume       = {59},
  year         = {2004},
}

Chicago
Van Hoof, Nathalie, K De Wasch, Sofie Poelmans, D Bruneel, S Spruyt, Herlinde Noppe, Colin Janssen, D Courtheyn, and Hubert De Brabander. 2004. “Norchlorotestosterone Acetate: An Alternative Metabolism Study and GC-MS2 Analysis in Kidney Fat, Urine, and Faeces.” Chromatographia 59: S85–S93.
APA
Van Hoof, N., De Wasch, K., Poelmans, S., Bruneel, D., Spruyt, S., Noppe, H., Janssen, C., et al. (2004). Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces. CHROMATOGRAPHIA, 59, S85–S93.
Vancouver
1.
Van Hoof N, De Wasch K, Poelmans S, Bruneel D, Spruyt S, Noppe H, et al. Norchlorotestosterone acetate: an alternative metabolism study and GC-MS2 analysis in kidney fat, urine, and faeces. CHROMATOGRAPHIA. 2004;59:S85–S93.
MLA
Van Hoof, Nathalie, K De Wasch, Sofie Poelmans, et al. “Norchlorotestosterone Acetate: An Alternative Metabolism Study and GC-MS2 Analysis in Kidney Fat, Urine, and Faeces.” CHROMATOGRAPHIA 59 (2004): S85–S93. Print.