Advanced search
1 file | 137.58 KB Add to list

Re-188-HDD/Lipiodol therapy for hepatocellular carcinoma: a phase I clinical trial

(2005) JOURNAL OF NUCLEAR MEDICINE. 46(1). p.60-66
Author
Organization
Abstract
The aim of this study was to investigate the pharmacokinetics organ closimetry, and toxicity after the intraarterial administration of Re-188-labeled 4-hexadecyl-1,2,9,9-tetramethyl-4,7diaza-1,10-decanethiol/lipiodol (Re-188-HDD/lipiodol) for palliative treatment of hepatocellular carcinoma (HCC). A secondary objective was to document the response. Methods: A mean activity of 3.60 GBq Re-188-HDD/lipiodol (range, 1.86-4.14 Gl3q) was administered to 11 patients (16 treatment sessions) via a transfemoral catheter. The pharmacokinetic and dosimetric data were collected by means of venous blood samples, urine collections, and 4 or 5 gamma-scintigraphies over 76 h. Absorbed doses to the various organs were calculated according to the MIRD formalism, using the MIRDOSE3.1 software. The toxicity was assessed until 6 wk after administration by means of the Common Toxicity Criteria scale. The response was evaluated on MRI and by monitoring of the tumor marker. Results: A fast blood clearance of the injected activity was observed with a calculated effective half-life of 7.6 +/- 2.2 h (+/-SD) in blood. The predominant elimination of the activity was through urinary excretion with a mean renal clearance of 44.1 % +/- 11.7% (+/-SD) of the injected activity within the 76 h after administration. Fecal elimination was negligible. The calculated whole-body effective half-life was 14.3 +/- 0.9 h (+/-SD). The absorbed dose to the liver tissue, the lungs, the kidneys, and the thyroid was 4.5 +/- 1.9, 4.1 +/- 1.2, 0.9 +/- 0.7, and 0.3 +/- 0.1 Gy, respectively. Treatment was well tolerated, except in 2 patients. One Child B patient experienced a worsening of his liver dysfunction (hyperbilirubinemia) and another patient experienced dyspnea and coughing. Response assessment on MRI showed 1 case of partial response, disease stabilization in 11 treatments, and progressive disease in 1 treatment. In 5 of 8 treatment sessions with an initially elevated a-fetoprotein, a reduction (range, 19%-90%) was observed 6 wk later. Conclusion: After the intraarterial administration of 3.60 GBq Re-188-HDD/lipiodol, a fast clearance of the activity appearing in the blood is observed and the predominant elimination is through urinary excretion. The tolerance as well as the preliminary response rates of the present phase I study are encouraging.
Keywords
lipiodol, hepatocellular carcinoma, Re-188, radionuclide therapy, 4-hexadecyl-1, 2, 9, 9-tetramethyl-4, 7-diaza-1, 10-decanethiol, HEPATIC-ARTERY, I-131-LIPIODOL THERAPY, LIVER-CANCER, LIPIODOL, DOSIMETRY, RE-188, BIODISTRIBUTION, TUMORS, CHEMOEMBOLIZATION, GENERATOR

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 137.58 KB

Citation

Please use this url to cite or link to this publication:

MLA
Lambert, Bieke, et al. “Re-188-HDD/Lipiodol Therapy for Hepatocellular Carcinoma: A Phase I Clinical Trial.” JOURNAL OF NUCLEAR MEDICINE, vol. 46, no. 1, 2005, pp. 60–66.
APA
Lambert, B., Bacher, K., Defreyne, L., Gemmel, F., Van Vlierberghe, H., Jeong, J. M., … De Vos, F. (2005). Re-188-HDD/Lipiodol therapy for hepatocellular carcinoma: a phase I clinical trial. JOURNAL OF NUCLEAR MEDICINE, 46(1), 60–66.
Chicago author-date
Lambert, Bieke, Klaus Bacher, Luc Defreyne, Filip Gemmel, Hans Van Vlierberghe, Jae Min Jeong, Rudi Dierckx, Christophe Van De Wiele, Hubert Thierens, and Filip De Vos. 2005. “Re-188-HDD/Lipiodol Therapy for Hepatocellular Carcinoma: A Phase I Clinical Trial.” JOURNAL OF NUCLEAR MEDICINE 46 (1): 60–66.
Chicago author-date (all authors)
Lambert, Bieke, Klaus Bacher, Luc Defreyne, Filip Gemmel, Hans Van Vlierberghe, Jae Min Jeong, Rudi Dierckx, Christophe Van De Wiele, Hubert Thierens, and Filip De Vos. 2005. “Re-188-HDD/Lipiodol Therapy for Hepatocellular Carcinoma: A Phase I Clinical Trial.” JOURNAL OF NUCLEAR MEDICINE 46 (1): 60–66.
Vancouver
1.
Lambert B, Bacher K, Defreyne L, Gemmel F, Van Vlierberghe H, Jeong JM, et al. Re-188-HDD/Lipiodol therapy for hepatocellular carcinoma: a phase I clinical trial. JOURNAL OF NUCLEAR MEDICINE. 2005;46(1):60–6.
IEEE
[1]
B. Lambert et al., “Re-188-HDD/Lipiodol therapy for hepatocellular carcinoma: a phase I clinical trial,” JOURNAL OF NUCLEAR MEDICINE, vol. 46, no. 1, pp. 60–66, 2005.
@article{303070,
  abstract     = {{The aim of this study was to investigate the pharmacokinetics organ closimetry, and toxicity after the intraarterial administration of Re-188-labeled 4-hexadecyl-1,2,9,9-tetramethyl-4,7diaza-1,10-decanethiol/lipiodol (Re-188-HDD/lipiodol) for palliative treatment of hepatocellular carcinoma (HCC). A secondary objective was to document the response. Methods: A mean activity of 3.60 GBq Re-188-HDD/lipiodol (range, 1.86-4.14 Gl3q) was administered to 11 patients (16 treatment sessions) via a transfemoral catheter. The pharmacokinetic and dosimetric data were collected by means of venous blood samples, urine collections, and 4 or 5 gamma-scintigraphies over 76 h. Absorbed doses to the various organs were calculated according to the MIRD formalism, using the MIRDOSE3.1 software. The toxicity was assessed until 6 wk after administration by means of the Common Toxicity Criteria scale. The response was evaluated on MRI and by monitoring of the tumor marker. Results: A fast blood clearance of the injected activity was observed with a calculated effective half-life of 7.6 +/- 2.2 h (+/-SD) in blood. The predominant elimination of the activity was through urinary excretion with a mean renal clearance of 44.1 % +/- 11.7% (+/-SD) of the injected activity within the 76 h after administration. Fecal elimination was negligible. The calculated whole-body effective half-life was 14.3 +/- 0.9 h (+/-SD). The absorbed dose to the liver tissue, the lungs, the kidneys, and the thyroid was 4.5 +/- 1.9, 4.1 +/- 1.2, 0.9 +/- 0.7, and 0.3 +/- 0.1 Gy, respectively. Treatment was well tolerated, except in 2 patients. One Child B patient experienced a worsening of his liver dysfunction (hyperbilirubinemia) and another patient experienced dyspnea and coughing. Response assessment on MRI showed 1 case of partial response, disease stabilization in 11 treatments, and progressive disease in 1 treatment. In 5 of 8 treatment sessions with an initially elevated a-fetoprotein, a reduction (range, 19%-90%) was observed 6 wk later. Conclusion: After the intraarterial administration of 3.60 GBq Re-188-HDD/lipiodol, a fast clearance of the activity appearing in the blood is observed and the predominant elimination is through urinary excretion. The tolerance as well as the preliminary response rates of the present phase I study are encouraging.}},
  author       = {{Lambert, Bieke and Bacher, Klaus and Defreyne, Luc and Gemmel, Filip and Van Vlierberghe, Hans and Jeong, Jae Min and Dierckx, Rudi and Van De Wiele, Christophe and Thierens, Hubert and De Vos, Filip}},
  issn         = {{0161-5505}},
  journal      = {{JOURNAL OF NUCLEAR MEDICINE}},
  keywords     = {{lipiodol,hepatocellular carcinoma,Re-188,radionuclide therapy,4-hexadecyl-1,2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol,HEPATIC-ARTERY,I-131-LIPIODOL THERAPY,LIVER-CANCER,LIPIODOL,DOSIMETRY,RE-188,BIODISTRIBUTION,TUMORS,CHEMOEMBOLIZATION,GENERATOR}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{60--66}},
  title        = {{Re-188-HDD/Lipiodol therapy for hepatocellular carcinoma: a phase I clinical trial}},
  url          = {{http://jnm.snmjournals.org/cgi/content/abstract/46/1/60}},
  volume       = {{46}},
  year         = {{2005}},
}

Web of Science
Times cited: