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Cystic fibrosis gut microbiota: diversity, temporal stability and antibiotic resistance

Gwen Duytschaever UGent (2012)
abstract
As a result of recurrent lung infections, patients with cystic fibrosis (CF) are frequently treated with high doses of antibiotics. Growing concern exists about the impact of these therapeutic interventions on the ecological balance of the indigenous gut microbiota, and the development and spread of antibiotic resistant strains. Furthermore, it is suspected that antibiotic-induced dysbiosis might increase the risk for GI and extra-intestinal complications such as pulmonary exacerbations by interfering with key host-microbe interactions, and thus immuno-regulatory functions. In addition, also CF-associated GI complications might be associated with GI dysbiosis. Hence, from a clinical point of view it is of paramount importance to document the nature, structure and underlying mechanisms of GI dysbiosis in patients with CF. Moreover, a profound insight into this gut microbial ecosystem is essential to provide a framework for steering the development of next-generation therapeutic drug targets, and implementing alternative biotherapeutic strategies based on functional foods. Up till now the composition and dynamics of the digestive microbiota in this patient population remained virtually unexplored. Therefore, the ultimate goal of the current thesis was to obtain a first profound insight into the GI microbial ecosystem of patients with CF in relation to that of healthy siblings.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
DGGE, antibiotic resistance, dysbiosis, Cystic fibrosis, gut microbiota
pages
VIII, 207 pages
publisher
Ghent University. Faculty of Sciences
place of publication
Ghent, Belgium
defense location
Gent : Aula Universiteit
defense date
2012-06-01 17:00
ISBN
9789461970473
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
3030609
handle
http://hdl.handle.net/1854/LU-3030609
date created
2012-10-17 17:01:15
date last changed
2012-10-18 09:06:41
@phdthesis{3030609,
  abstract     = {As a result of recurrent lung infections, patients with cystic fibrosis (CF) are frequently treated with high doses of antibiotics. Growing concern exists about the impact of these therapeutic interventions on the ecological balance of the indigenous gut microbiota, and the development and spread of antibiotic resistant strains. Furthermore, it is suspected that antibiotic-induced dysbiosis might increase the risk for GI and extra-intestinal complications such as pulmonary exacerbations by interfering with key host-microbe interactions, and thus immuno-regulatory functions. In addition, also CF-associated GI complications might be associated with GI dysbiosis. Hence, from a clinical point of view it is of paramount importance to document the nature, structure and underlying mechanisms of GI dysbiosis in patients with CF. Moreover, a profound insight into this gut microbial ecosystem is essential to provide a framework for steering the development of next-generation therapeutic drug targets, and implementing alternative biotherapeutic strategies based on functional foods. Up till now the composition and dynamics of the digestive microbiota in this patient population remained virtually unexplored. Therefore, the ultimate goal of the current thesis was to obtain a first profound insight into the GI microbial ecosystem of patients with CF in relation to that of healthy siblings.},
  author       = {Duytschaever, Gwen},
  isbn         = {9789461970473},
  keyword      = {DGGE,antibiotic resistance,dysbiosis,Cystic fibrosis,gut microbiota},
  language     = {eng},
  pages        = {VIII, 207},
  publisher    = {Ghent University. Faculty of Sciences},
  school       = {Ghent University},
  title        = {Cystic fibrosis gut microbiota: diversity, temporal stability and antibiotic resistance},
  year         = {2012},
}

Chicago
Duytschaever, Gwen. 2012. “Cystic Fibrosis Gut Microbiota: Diversity, Temporal Stability and Antibiotic Resistance”. Ghent, Belgium: Ghent University. Faculty of Sciences.
APA
Duytschaever, G. (2012). Cystic fibrosis gut microbiota: diversity, temporal stability and antibiotic resistance. Ghent University. Faculty of Sciences, Ghent, Belgium.
Vancouver
1.
Duytschaever G. Cystic fibrosis gut microbiota: diversity, temporal stability and antibiotic resistance. [Ghent, Belgium]: Ghent University. Faculty of Sciences; 2012.
MLA
Duytschaever, Gwen. “Cystic Fibrosis Gut Microbiota: Diversity, Temporal Stability and Antibiotic Resistance.” 2012 : n. pag. Print.