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Benzalkonium chloride induces anterior chamber inflammation in previously untreated patients with ocular hypertension as measured by flare meter: a randomized clinical trial

Anna Maria Stevens, PHILIPPE ADRIAAN KESTELYN UGent, Dirk De Bacquer UGent and Philippe Kestelyn UGent (2012) ACTA OPHTHALMOLOGICA. 90(3). p.e221-e224
abstract
Purpose: The deleterious effects of benzalkonium chloride (BAK) on the ocular surface are well known. However, few clinical data are available to prove a toxic effect at the level of the anterior chamber. The laser flare meter is a reliable tool to detect low levels of inflammation in the anterior chamber. We wanted to know whether instillation of BAK-preserved timolol in one eye would result in higher laser flare values than the instillation of preservative-free timolol in the fellow eye. Methods: Randomized prospective, single-masked clinical trial. Twenty-eight untreated patients with ocular hypertension were recruited. After obtaining baseline flare values, we randomly assigned one eye to BAK-preserved timolol and the fellow eye to preservative-free timolol. After 1 month, flare measurements were repeated. Results: There was a significant increase in the flare values in the two treatment regimens, but the increase in the BAK-treated eyes was higher than in the preservative-free treated eyes, and this difference in increase was statistically significant. Conclusion: This is the first study to show that short-term BAK administration produces inflammation in the anterior segment of previously untreated patients whose bloodaqueous barrier was not affected by recent intraocular surgery.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
AQUEOUS FLARE, HUMOR PROTEIN-CONCENTRATION, QUANTITATIVE-DETERMINATION, INTRAOCULAR-PRESSURE, GLAUCOMA MEDICATION, TOPICAL TIMOLOL, HEALTHY EYES, CELL NUMBER, PREVALENCE, TRABECULECTOMY, glaucoma medication, laser flare meter, anterior chamber inflammation, benzalkonium chloride
journal title
ACTA OPHTHALMOLOGICA
Acta Ophthalmol.
volume
90
issue
3
pages
e221 - e224
Web of Science type
Article
Web of Science id
000303311400014
JCR category
OPHTHALMOLOGY
JCR impact factor
2.345 (2012)
JCR rank
15/58 (2012)
JCR quartile
2 (2012)
ISSN
1755-375X
DOI
10.1111/j.1755-3768.2011.02338.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3030407
handle
http://hdl.handle.net/1854/LU-3030407
date created
2012-10-17 14:37:55
date last changed
2012-10-18 11:01:15
@article{3030407,
  abstract     = {Purpose: The deleterious effects of benzalkonium chloride (BAK) on the ocular surface are well known. However, few clinical data are available to prove a toxic effect at the level of the anterior chamber. The laser flare meter is a reliable tool to detect low levels of inflammation in the anterior chamber. We wanted to know whether instillation of BAK-preserved timolol in one eye would result in higher laser flare values than the instillation of preservative-free timolol in the fellow eye.
Methods: Randomized prospective, single-masked clinical trial. Twenty-eight untreated patients with ocular hypertension were recruited. After obtaining baseline flare values, we randomly assigned one eye to BAK-preserved timolol and the fellow eye to preservative-free timolol. After 1 month, flare measurements were repeated.
Results: There was a significant increase in the flare values in the two treatment regimens, but the increase in the BAK-treated eyes was higher than in the preservative-free treated eyes, and this difference in increase was statistically significant.
Conclusion: This is the first study to show that short-term BAK administration produces inflammation in the anterior segment of previously untreated patients whose bloodaqueous barrier was not affected by recent intraocular surgery.},
  author       = {Stevens, Anna Maria and KESTELYN, PHILIPPE ADRIAAN and De Bacquer, Dirk and Kestelyn, Philippe},
  issn         = {1755-375X},
  journal      = {ACTA OPHTHALMOLOGICA},
  keyword      = {AQUEOUS FLARE,HUMOR PROTEIN-CONCENTRATION,QUANTITATIVE-DETERMINATION,INTRAOCULAR-PRESSURE,GLAUCOMA MEDICATION,TOPICAL TIMOLOL,HEALTHY EYES,CELL NUMBER,PREVALENCE,TRABECULECTOMY,glaucoma medication,laser flare meter,anterior chamber inflammation,benzalkonium chloride},
  language     = {eng},
  number       = {3},
  pages        = {e221--e224},
  title        = {Benzalkonium chloride induces anterior chamber inflammation in previously untreated patients with ocular hypertension as measured by flare meter: a randomized clinical trial},
  url          = {http://dx.doi.org/10.1111/j.1755-3768.2011.02338.x},
  volume       = {90},
  year         = {2012},
}

Chicago
Stevens, Anna Maria, PHILIPPE ADRIAAN KESTELYN, Dirk De Bacquer, and Philippe Kestelyn. 2012. “Benzalkonium Chloride Induces Anterior Chamber Inflammation in Previously Untreated Patients with Ocular Hypertension as Measured by Flare Meter: a Randomized Clinical Trial.” Acta Ophthalmologica 90 (3): e221–e224.
APA
Stevens, A. M., KESTELYN, P. A., De Bacquer, D., & Kestelyn, P. (2012). Benzalkonium chloride induces anterior chamber inflammation in previously untreated patients with ocular hypertension as measured by flare meter: a randomized clinical trial. ACTA OPHTHALMOLOGICA, 90(3), e221–e224.
Vancouver
1.
Stevens AM, KESTELYN PA, De Bacquer D, Kestelyn P. Benzalkonium chloride induces anterior chamber inflammation in previously untreated patients with ocular hypertension as measured by flare meter: a randomized clinical trial. ACTA OPHTHALMOLOGICA. 2012;90(3):e221–e224.
MLA
Stevens, Anna Maria, PHILIPPE ADRIAAN KESTELYN, Dirk De Bacquer, et al. “Benzalkonium Chloride Induces Anterior Chamber Inflammation in Previously Untreated Patients with Ocular Hypertension as Measured by Flare Meter: a Randomized Clinical Trial.” ACTA OPHTHALMOLOGICA 90.3 (2012): e221–e224. Print.