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Efficacy and safety of deep sclerectomy in childhood glaucoma in Saudi Arabia

SA Al-Obeidan, EA Osman, AS Dewedar, Philippe Kestelyn UGent and A Mousa (2014) ACTA OPHTHALMOLOGICA. 92(1). p.65-70
abstract
Purpose: To evaluate the efficacy and safety of deep sclerectomy in childhood glaucoma. Methods: A prospective cohort of 120 children presenting with glaucoma to King Abdul Aziz University Hospital (KAUH) was subjected to nonpenetrating deep sclerectomy surgery (NPDS). Eventually, 57 patients had macro perforation and converted to penetrating deep sclerectomy (PDS). Intra-operative mitomycin C (MMC) 0.2mg/ml was used in all patients. Pre- and postintervention glaucoma indices were assessed. Complete success rate (CSR) was identified as achieving an end-point of intraocular pressure <21 without any antiglaucoma medications. Data were analysed to compare pre- and postintervention changes and to compare both procedures. Results: After follow-up of 35.8 (34.5) months, NPDS procedure went smooth in 74 eyes of 63 patients. The complete success rate was 79.7%, whereas the overall success rate was 82.4%. Thirteen cases failed. The probability to survive was 74.6% after the 12th month. The mean intraocular pressure (IOP) went down to 11.53.0mmHg compared to 31.9mmHg preoperatively. Comparing cases with NPDS to those with PDS, the magnitude of IOP reduction (15.8) was higher than that of the PDS (14.8); however, this difference was not statistically significant (p=0.259). Apart from involuntary perforation of trabeculodescemetic window (TDW), neither intra-operative nor early postoperative complications were observed. Conclusions: Deep sclerectomy in childhood glaucoma can effectively reduce the IOP, without the occurrence of serious complications that are commonly seen after trabeculotomy or combined trabeculotomy trabeculectomy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
glaucoma surgery, congenital glaucoma, deep sclerectomy, Saudi Arabia, CONGENITAL GLAUCOMA, COMBINED TRABECULOTOMY, DEVELOPMENTAL GLAUCOMA, COLLAGEN IMPLANT, FOLLOW-UP, TRABECULECTOMY, SURGERY, BLINDNESS
journal title
ACTA OPHTHALMOLOGICA
Acta Ophthalmol.
volume
92
issue
1
pages
65 - 70
Web of Science type
Article
Web of Science id
000329925000018
ISSN
1755-375X
DOI
10.1111/j.1755-3768.2012.02558.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3030388
handle
http://hdl.handle.net/1854/LU-3030388
date created
2012-10-17 14:18:57
date last changed
2015-04-02 12:58:48
@article{3030388,
  abstract     = {Purpose: To evaluate the efficacy and safety of deep sclerectomy in childhood glaucoma.
Methods: A prospective cohort of 120 children presenting with glaucoma to King Abdul Aziz University Hospital (KAUH) was subjected to nonpenetrating deep sclerectomy surgery (NPDS). Eventually, 57 patients had macro perforation and converted to penetrating deep sclerectomy (PDS). Intra-operative mitomycin C (MMC) 0.2mg/ml was used in all patients. Pre- and postintervention glaucoma indices were assessed. Complete success rate (CSR) was identified as achieving an end-point of intraocular pressure {\textlangle}21 without any antiglaucoma medications. Data were analysed to compare pre- and postintervention changes and to compare both procedures.
Results: After follow-up of 35.8 (34.5) months, NPDS procedure went smooth in 74 eyes of 63 patients. The complete success rate was 79.7\%, whereas the overall success rate was 82.4\%. Thirteen cases failed. The probability to survive was 74.6\% after the 12th month. The mean intraocular pressure (IOP) went down to 11.53.0mmHg compared to 31.9mmHg preoperatively. Comparing cases with NPDS to those with PDS, the magnitude of IOP reduction (15.8) was higher than that of the PDS (14.8); however, this difference was not statistically significant (p=0.259). Apart from involuntary perforation of trabeculodescemetic window (TDW), neither intra-operative nor early postoperative complications were observed.
Conclusions: Deep sclerectomy in childhood glaucoma can effectively reduce the IOP, without the occurrence of serious complications that are commonly seen after trabeculotomy or combined trabeculotomy trabeculectomy.},
  author       = {Al-Obeidan, SA and Osman, EA and Dewedar, AS and Kestelyn, Philippe and Mousa, A},
  issn         = {1755-375X},
  journal      = {ACTA OPHTHALMOLOGICA},
  keyword      = {glaucoma surgery,congenital glaucoma,deep sclerectomy,Saudi Arabia,CONGENITAL GLAUCOMA,COMBINED TRABECULOTOMY,DEVELOPMENTAL GLAUCOMA,COLLAGEN IMPLANT,FOLLOW-UP,TRABECULECTOMY,SURGERY,BLINDNESS},
  language     = {eng},
  number       = {1},
  pages        = {65--70},
  title        = {Efficacy and safety of deep sclerectomy in childhood glaucoma in Saudi Arabia},
  url          = {http://dx.doi.org/10.1111/j.1755-3768.2012.02558.x},
  volume       = {92},
  year         = {2014},
}

Chicago
Al-Obeidan, SA, EA Osman, AS Dewedar, Philippe Kestelyn, and A Mousa. 2014. “Efficacy and Safety of Deep Sclerectomy in Childhood Glaucoma in Saudi Arabia.” Acta Ophthalmologica 92 (1): 65–70.
APA
Al-Obeidan, S., Osman, E., Dewedar, A., Kestelyn, P., & Mousa, A. (2014). Efficacy and safety of deep sclerectomy in childhood glaucoma in Saudi Arabia. ACTA OPHTHALMOLOGICA, 92(1), 65–70.
Vancouver
1.
Al-Obeidan S, Osman E, Dewedar A, Kestelyn P, Mousa A. Efficacy and safety of deep sclerectomy in childhood glaucoma in Saudi Arabia. ACTA OPHTHALMOLOGICA. 2014;92(1):65–70.
MLA
Al-Obeidan, SA, EA Osman, AS Dewedar, et al. “Efficacy and Safety of Deep Sclerectomy in Childhood Glaucoma in Saudi Arabia.” ACTA OPHTHALMOLOGICA 92.1 (2014): 65–70. Print.