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Muscle mass, muscle strength, functional performance, and physical impairment in women with the hypermobility type of Ehlers Danlos syndrome

Lies Rombaut UGent, Fransiska Malfait UGent, Inge De Wandele UGent, Youri Taes UGent, Youri Thijs UGent, Anne De Paepe UGent and Patrick Calders UGent (2012) ARTHRITIS CARE & RESEARCH. 64(10). p.1584-1592
abstract
Objective : To investigate lower extremity muscle mass, muscle strength, functional performance, and physical impairment in women with the Ehlers-Danlos syndrome hypermobility type (EDS-HT). Methods : Forty-three women with EDS-HT and 43 sex- and age-matched healthy control subjects participated. Muscle mass was determined by dual x-ray absorptiometry. Muscle strength and muscle strength endurance were measured with isokinetic dynamometry at angular velocities of 60, 180, and 240 degrees/second. Static muscle endurance during posture maintenance was also assessed. Pain and fatigue were simultaneously evaluated by visual analog scale and the Borg scale, respectively. In addition, the chair rise test for assessment of functional performance and the Arthritis Impact Measurement Scales (AIMS) for physical impairment evaluation were used. Results : Compared to control subjects, EDS-HT patients showed substantial lower extremity muscle weakness, reflected by significantly reduced knee extensor and flexor muscle strength and endurance parameters, with differences ranging from -30% to -49%; reduced static muscle endurance time; and diminished functional performance. Lower extremity muscle mass was similar in both groups and unlikely to affect the muscle strength results. By contrast, pain and fatigue were omnipresent and increased remarkably due to the tests. Furthermore, the EDS-HT group was physically impaired, especially in the AIMS domain walking and bending. Conclusion : This study demonstrates severely reduced quantitative muscle function and impairment in physical function in patients with EDS-HT compared to age- and sex-matched controls. The muscle weakness may be due to muscle dysfunction rather than reduced muscle mass. Whether muscle strength and endurance can be improved by appropriate exercise programs needs evaluation in further studies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
QUALITY-OF-LIFE, RHEUMATOID-ARTHRITIS, muscle strength, functional performance, hypermobility, Ehlers Danlos Syndrome, CONNECTIVE-TISSUE, HERITABLE DISORDERS, FIBROMYALGIA, FATIGUE, PAIN, NOSOLOGY, EXERCISE, BALANCE
journal title
ARTHRITIS CARE & RESEARCH
Arthritis Care Res.
volume
64
issue
10
pages
1584 - 1592
Web of Science type
Article
Web of Science id
000309391700016
JCR category
RHEUMATOLOGY
JCR impact factor
3.731 (2012)
JCR rank
9/29 (2012)
JCR quartile
2 (2012)
ISSN
2151-464X
DOI
10.1002/acr.21726
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3030006
handle
http://hdl.handle.net/1854/LU-3030006
date created
2012-10-16 16:05:19
date last changed
2013-07-10 16:10:59
@article{3030006,
  abstract     = {Objective : To investigate lower extremity muscle mass, muscle strength, functional performance, and physical impairment in women with the Ehlers-Danlos syndrome hypermobility type (EDS-HT).
Methods : Forty-three women with EDS-HT and 43 sex- and age-matched healthy control subjects participated. Muscle mass was determined by dual x-ray absorptiometry. Muscle strength and muscle strength endurance were measured with isokinetic dynamometry at angular velocities of 60, 180, and 240 degrees/second. Static muscle endurance during posture maintenance was also assessed. Pain and fatigue were simultaneously evaluated by visual analog scale and the Borg scale, respectively. In addition, the chair rise test for assessment of functional performance and the Arthritis Impact Measurement Scales (AIMS) for physical impairment evaluation were used.
Results : Compared to control subjects, EDS-HT patients showed substantial lower extremity muscle weakness, reflected by significantly reduced knee extensor and flexor muscle strength and endurance parameters, with differences ranging from -30\% to -49\%; reduced static muscle endurance time; and diminished functional performance. Lower extremity muscle mass was similar in both groups and unlikely to affect the muscle strength results. By contrast, pain and fatigue were omnipresent and increased remarkably due to the tests. Furthermore, the EDS-HT group was physically impaired, especially in the AIMS domain walking and bending.
Conclusion : This study demonstrates severely reduced quantitative muscle function and impairment in physical function in patients with EDS-HT compared to age- and sex-matched controls. The muscle weakness may be due to muscle dysfunction rather than reduced muscle mass. Whether muscle strength and endurance can be improved by appropriate exercise programs needs evaluation in further studies.},
  author       = {Rombaut, Lies and Malfait, Fransiska and De Wandele, Inge and Taes, Youri and Thijs, Youri and De Paepe, Anne and Calders, Patrick},
  issn         = {2151-464X},
  journal      = {ARTHRITIS CARE \& RESEARCH},
  keyword      = {QUALITY-OF-LIFE,RHEUMATOID-ARTHRITIS,muscle strength,functional performance,hypermobility,Ehlers Danlos Syndrome,CONNECTIVE-TISSUE,HERITABLE DISORDERS,FIBROMYALGIA,FATIGUE,PAIN,NOSOLOGY,EXERCISE,BALANCE},
  language     = {eng},
  number       = {10},
  pages        = {1584--1592},
  title        = {Muscle mass, muscle strength, functional performance, and physical impairment in women with the hypermobility type of Ehlers Danlos syndrome},
  url          = {http://dx.doi.org/10.1002/acr.21726},
  volume       = {64},
  year         = {2012},
}

Chicago
Rombaut, Lies, Fransiska Malfait, Inge De Wandele, Youri Taes, Youri Thijs, Anne De Paepe, and Patrick Calders. 2012. “Muscle Mass, Muscle Strength, Functional Performance, and Physical Impairment in Women with the Hypermobility Type of Ehlers Danlos Syndrome.” Arthritis Care & Research 64 (10): 1584–1592.
APA
Rombaut, L., Malfait, F., De Wandele, I., Taes, Y., Thijs, Y., De Paepe, A., & Calders, P. (2012). Muscle mass, muscle strength, functional performance, and physical impairment in women with the hypermobility type of Ehlers Danlos syndrome. ARTHRITIS CARE & RESEARCH, 64(10), 1584–1592.
Vancouver
1.
Rombaut L, Malfait F, De Wandele I, Taes Y, Thijs Y, De Paepe A, et al. Muscle mass, muscle strength, functional performance, and physical impairment in women with the hypermobility type of Ehlers Danlos syndrome. ARTHRITIS CARE & RESEARCH. 2012;64(10):1584–92.
MLA
Rombaut, Lies, Fransiska Malfait, Inge De Wandele, et al. “Muscle Mass, Muscle Strength, Functional Performance, and Physical Impairment in Women with the Hypermobility Type of Ehlers Danlos Syndrome.” ARTHRITIS CARE & RESEARCH 64.10 (2012): 1584–1592. Print.