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Radiation-induced oesophagitis in lung cancer patients: is susceptibility for neutropenia a risk factor?

Dirk De Ruysscher, Jan Van Meerbeeck UGent, Katrien Vandecasteele UGent, Cary Oberije, Madelon Pijls, Anne-Marie C Dingemans, Bart Reymen, Angela van Baardwijk, Rinus Wanders and G Lammering, et al. (2012) STRAHLENTHERAPIE UND ONKOLOGIE. 188(7). p.564-567
abstract
Radiation-induced oesophagitis is a major side effect of concurrent chemotherapy and radiotherapy. A strong association between neutropenia and oesophagitis was previously shown, but external validation and further elucidation of the possible mechanisms are lacking. A total of 119 patients were included at two institutions. The concurrent group comprised 34 SCLC patients treated with concurrent carboplatin and etoposide, and concurrent chest irradiation, and 36 NSCLC patients with concurrent cisplatin and etoposide, and concurrent radiotherapy, while the sequential group comprised 49 NSCLC patients received sequential cisplatin and gemcitabine, and radiotherapy. Severe neutropenia was very frequent during concurrent chemoradiation (grade: 4 41.4%) and during induction chemotherapy in sequentially treated patients (grade 4: 30.6%), but not during radiotherapy (only 4% grade 1). In the concurrent group, the odds ratios of grade 3 oesophagitis vs. neutropenia were the following: grade 2 vs. grade 0/1: 5.60 (95% CI 1.55-20.26), p = 0.009; grade 3 vs. grade 0/1: 10.40 (95% CI 3.19-33.95); p = 0.0001; grade 4 vs. grade 0/1: 12.60 (95% CI 4.36-36.43); p < 0.00001. There was no correlation between the occurrence of neutropenia during induction chemotherapy and acute oesophagitis during or after radiotherapy alone. In the univariate analysis, total radiation dose (p < 0.001), overall treatment time of radiotherapy (p < 0.001), mean oesophageal dose (p = 0.038) and neutropenia (p < 0.001) were significantly associated with the development of oesophagitis. In a multivariate analysis, only neutropenia remained significant (p = 0.023). We confirm that neutropenia is independently correlated with oesophagitis in concurrent chemoradiation, but that the susceptibility for chemotherapy-induced neutropenia is not associated with radiation-induced oesophagitis. Further studies focusing on the underlying mechanisms are thus warranted.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
INDUCED DYSPHAGIA, PROPHYLAXIS, THORACIC RADIOTHERAPY, INDUCTION CHEMOTHERAPY, Oesophagitis, Dysphagia, Radiotherapy, Toxicity, Lung cancer, CONCURRENT, TOXICITY, THERAPY
journal title
STRAHLENTHERAPIE UND ONKOLOGIE
Strahlenther. Onkol.
volume
188
issue
7
pages
564 - 567
Web of Science type
Article
Web of Science id
000305468800004
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
4.163 (2012)
JCR rank
12/119 (2012)
JCR quartile
1 (2012)
ISSN
0179-7158
DOI
10.1007/s00066-012-0098-z
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3029136
handle
http://hdl.handle.net/1854/LU-3029136
date created
2012-10-15 16:40:21
date last changed
2014-07-29 16:56:09
@article{3029136,
  abstract     = {Radiation-induced oesophagitis is a major side effect of concurrent chemotherapy and radiotherapy. A strong association between neutropenia and oesophagitis was previously shown, but external validation and further elucidation of the possible mechanisms are lacking. 
A total of 119 patients were included at two institutions. The concurrent group comprised 34 SCLC patients treated with concurrent carboplatin and etoposide, and concurrent chest irradiation, and 36 NSCLC patients with concurrent cisplatin and etoposide, and concurrent radiotherapy, while the sequential group comprised 49 NSCLC patients received sequential cisplatin and gemcitabine, and radiotherapy. 
Severe neutropenia was very frequent during concurrent chemoradiation (grade: 4 41.4\%) and during induction chemotherapy in sequentially treated patients (grade 4: 30.6\%), but not during radiotherapy (only 4\% grade 1). In the concurrent group, the odds ratios of grade 3 oesophagitis vs. neutropenia were the following: grade 2 vs. grade 0/1: 5.60 (95\% CI 1.55-20.26), p = 0.009; grade 3 vs. grade 0/1: 10.40 (95\% CI 3.19-33.95); p = 0.0001; grade 4 vs. grade 0/1: 12.60 (95\% CI 4.36-36.43); p {\textlangle} 0.00001. There was no correlation between the occurrence of neutropenia during induction chemotherapy and acute oesophagitis during or after radiotherapy alone. In the univariate analysis, total radiation dose (p {\textlangle} 0.001), overall treatment time of radiotherapy (p {\textlangle} 0.001), mean oesophageal dose (p = 0.038) and neutropenia (p {\textlangle} 0.001) were significantly associated with the development of oesophagitis. In a multivariate analysis, only neutropenia remained significant (p = 0.023). 
We confirm that neutropenia is independently correlated with oesophagitis in concurrent chemoradiation, but that the susceptibility for chemotherapy-induced neutropenia is not associated with radiation-induced oesophagitis. Further studies focusing on the underlying mechanisms are thus warranted.},
  author       = {De Ruysscher, Dirk and Van Meerbeeck, Jan and Vandecasteele, Katrien and Oberije, Cary and Pijls, Madelon and Dingemans, Anne-Marie C and Reymen, Bart and van Baardwijk, Angela and Wanders, Rinus and Lammering, G and Lambin, Philippe and De Neve, Wilfried},
  issn         = {0179-7158},
  journal      = {STRAHLENTHERAPIE UND ONKOLOGIE},
  keyword      = {INDUCED DYSPHAGIA,PROPHYLAXIS,THORACIC RADIOTHERAPY,INDUCTION CHEMOTHERAPY,Oesophagitis,Dysphagia,Radiotherapy,Toxicity,Lung cancer,CONCURRENT,TOXICITY,THERAPY},
  language     = {eng},
  number       = {7},
  pages        = {564--567},
  title        = {Radiation-induced oesophagitis in lung cancer patients: is susceptibility for neutropenia a risk factor?},
  url          = {http://dx.doi.org/10.1007/s00066-012-0098-z},
  volume       = {188},
  year         = {2012},
}

Chicago
De Ruysscher, Dirk, Jan Van Meerbeeck, Katrien Vandecasteele, Cary Oberije, Madelon Pijls, Anne-Marie C Dingemans, Bart Reymen, et al. 2012. “Radiation-induced Oesophagitis in Lung Cancer Patients: Is Susceptibility for Neutropenia a Risk Factor?” Strahlentherapie Und Onkologie 188 (7): 564–567.
APA
De Ruysscher, Dirk, Van Meerbeeck, J., Vandecasteele, K., Oberije, C., Pijls, M., Dingemans, A.-M. C., Reymen, B., et al. (2012). Radiation-induced oesophagitis in lung cancer patients: is susceptibility for neutropenia a risk factor? STRAHLENTHERAPIE UND ONKOLOGIE, 188(7), 564–567.
Vancouver
1.
De Ruysscher D, Van Meerbeeck J, Vandecasteele K, Oberije C, Pijls M, Dingemans A-MC, et al. Radiation-induced oesophagitis in lung cancer patients: is susceptibility for neutropenia a risk factor? STRAHLENTHERAPIE UND ONKOLOGIE. 2012;188(7):564–7.
MLA
De Ruysscher, Dirk, Jan Van Meerbeeck, Katrien Vandecasteele, et al. “Radiation-induced Oesophagitis in Lung Cancer Patients: Is Susceptibility for Neutropenia a Risk Factor?” STRAHLENTHERAPIE UND ONKOLOGIE 188.7 (2012): 564–567. Print.