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Short cigarette smoke exposure facilitates sensitisation and asthma development in mice

Ellen Lanckacker UGent, Kurt Tournoy UGent, Hamida Hammad UGent, Gabriële Holtappels UGent, Bart Lambrecht UGent, Guy Joos UGent and Tania Maes UGent (2013) EUROPEAN RESPIRATORY JOURNAL. 41(5). p.1189-1199
abstract
Epidemiological studies indicate that cigarette smoke (CS) exposure is a risk factor for increased sensitization and asthma development. The aim of the study was to examine the impact of CS on sensitization and allergic airway inflammation, in response to a low dose of house dust mite (HDM), and to obtain potential mechanistic insights.Mice were exposed to low doses of HDM extract combined with air or CS exposure, either during allergen sensitization or during development of allergic airway disease.Mice concomitantly exposed to low dose HDM, combined with CS for 3 weeks, demonstrated an asthmatic phenotype with significantly increased airway eosinophilia, goblet cell metaplasia, airway hyperresponsiveness and a rise in HDM-specific serum IgG1, compared to sole HDM or CS exposure. In addition, short CS inhalation, during the initial contact with HDM allergens, was sufficient to facilitate sensitization and development of a complete asthmatic phenotype after rechallenge with HDM. Mechanistically, short CS exposure amplified DC-mediated transport of FITC-labelled HDM allergens to the intrathoracic lymph nodes and generated a local Th2 response.Short CS exposure is sufficient to facilitate allergic sensitization and the development of low dose HDM-induced allergic asthma, possibly through affecting dendritic cell function.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
dendritic cell, HOUSE-DUST MITE, environmental pollutants, murine, Airway allergy, ALLERGIC AIRWAY INFLAMMATION, DERMATOPHAGOIDES-PTERONYSSINUS, DENDRITIC CELLS, CARBOXYHEMOGLOBIN LEVELS, ENVIRONMENTAL TOBACCO-SMOKE, INDUCED PULMONARY INFLAMMATION, EPITHELIAL-CELLS, LUNG-FUNCTION, MOUSE MODEL
journal title
EUROPEAN RESPIRATORY JOURNAL
Eur. Resp. J.
volume
41
issue
5
pages
1189 - 1199
Web of Science type
Article
Web of Science id
000318750300029
JCR category
RESPIRATORY SYSTEM
JCR impact factor
7.125 (2013)
JCR rank
4/54 (2013)
JCR quartile
1 (2013)
ISSN
0903-1936
DOI
10.1183/09031936.00096612
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3028966
handle
http://hdl.handle.net/1854/LU-3028966
date created
2012-10-15 14:02:35
date last changed
2013-07-09 16:34:25
@article{3028966,
  abstract     = {Epidemiological studies indicate that cigarette smoke (CS) exposure is a risk factor for increased sensitization and asthma development. The aim of the study was to examine the impact of CS on sensitization and allergic airway inflammation, in response to a low dose of house dust mite (HDM), and to obtain potential mechanistic insights.Mice were exposed to low doses of HDM extract combined with air or CS exposure, either during allergen sensitization or during development of allergic airway disease.Mice concomitantly exposed to low dose HDM, combined with CS for 3 weeks, demonstrated an asthmatic phenotype with significantly increased airway eosinophilia, goblet cell metaplasia, airway hyperresponsiveness and a rise in HDM-specific serum IgG1, compared to sole HDM or CS exposure. In addition, short CS inhalation, during the initial contact with HDM allergens, was sufficient to facilitate sensitization and development of a complete asthmatic phenotype after rechallenge with HDM. Mechanistically, short CS exposure amplified DC-mediated transport of FITC-labelled HDM allergens to the intrathoracic lymph nodes and generated a local Th2 response.Short CS exposure is sufficient to facilitate allergic sensitization and the development of low dose HDM-induced allergic asthma, possibly through affecting dendritic cell function.},
  author       = {Lanckacker, Ellen and Tournoy, Kurt and Hammad, Hamida and Holtappels, Gabri{\"e}le and Lambrecht, Bart and Joos, Guy and Maes, Tania},
  issn         = {0903-1936},
  journal      = {EUROPEAN RESPIRATORY JOURNAL},
  keyword      = {dendritic cell,HOUSE-DUST MITE,environmental pollutants,murine,Airway allergy,ALLERGIC AIRWAY INFLAMMATION,DERMATOPHAGOIDES-PTERONYSSINUS,DENDRITIC CELLS,CARBOXYHEMOGLOBIN LEVELS,ENVIRONMENTAL TOBACCO-SMOKE,INDUCED PULMONARY INFLAMMATION,EPITHELIAL-CELLS,LUNG-FUNCTION,MOUSE MODEL},
  language     = {eng},
  number       = {5},
  pages        = {1189--1199},
  title        = {Short cigarette smoke exposure facilitates sensitisation and asthma development in mice},
  url          = {http://dx.doi.org/10.1183/09031936.00096612},
  volume       = {41},
  year         = {2013},
}

Chicago
Lanckacker, Ellen, Kurt Tournoy, Hamida Hammad, Gabriële Holtappels, Bart Lambrecht, Guy Joos, and Tania Maes. 2013. “Short Cigarette Smoke Exposure Facilitates Sensitisation and Asthma Development in Mice.” European Respiratory Journal 41 (5): 1189–1199.
APA
Lanckacker, E., Tournoy, K., Hammad, H., Holtappels, G., Lambrecht, B., Joos, G., & Maes, T. (2013). Short cigarette smoke exposure facilitates sensitisation and asthma development in mice. EUROPEAN RESPIRATORY JOURNAL, 41(5), 1189–1199.
Vancouver
1.
Lanckacker E, Tournoy K, Hammad H, Holtappels G, Lambrecht B, Joos G, et al. Short cigarette smoke exposure facilitates sensitisation and asthma development in mice. EUROPEAN RESPIRATORY JOURNAL. 2013;41(5):1189–99.
MLA
Lanckacker, Ellen, Kurt Tournoy, Hamida Hammad, et al. “Short Cigarette Smoke Exposure Facilitates Sensitisation and Asthma Development in Mice.” EUROPEAN RESPIRATORY JOURNAL 41.5 (2013): 1189–1199. Print.