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Experience with Lexicomp® Online Drug Database for medication review and drug-drug interaction analysis within a comprehensive geriatric assessment in elderly cancer patients

Lies Pottel, Michelle Lycke, Tom Boterberg UGent, Lore Ketelaars, Hans Pottel, Laurence Goethals, Nele Van Den Noortgate UGent, FREDERIC DUPREZ UGent, Wilfried De Neve UGent and Sylvie Rottey UGent, et al. (2012) JOURNAL OF ANALYTICAL ONCOLOGY. 1(1). p.32-41
abstract
Background: we studied the use of Lexicomp, an online drug information database, for adequate identification of drug-drug interactions within comprehensive geriatric assessment in cancer patients. Materials and Methods: data of 149 onco-geriatric patients were reviewed. Sixty-tree percent participated in an observational study recruiting head and neck cancer patients, 37% in a registry recruiting general oncology patients. Baseline drug information was collected by a health professional, through the medical interview within CGA. Drug class usage was quantified and potentional DDIs were assessed and categorized with Lexicomp. Results: on average, H&H and GO-patients took 5 and 8 prescription drugs at presentation, respectively. An average of 4 drugs were added in both groups as part of their proposed therapy. Potential DDIs were detected by Lexicomp in 64.9% and 83.6% of H&H and GO patients, respectively, at therapy start. Administration of cancer-therapy-related drugs lead to additional DDIs in 73.7% and 58.3% of H&H and GO cases, respectively. DDIs occured mainly with supportive drugs. Sixteen percent of potential DDIs were identified with anti-neoplastic drugs in the GO-group. Iin 28.7% and 60.0% of H&H and GO patients, respectively, at least one drug was recognized by Lexicomp. Conclusions: use of Lexicomp drug database within CGA is feasible. It could reduce the administration of inappropiate drugs, and in that way improve the quality of patient-individualized therapie.
Please use this url to cite or link to this publication:
author
organization
alternative title
Experience with Lexicomp (R) Online Drug Database for medication review and drug-drug interaction analysis within a comprehensive geriatric assessment in elderly cancer patients
year
type
journalArticle (original)
publication status
published
subject
keyword
drug-drug interactions, safe prescription behavior, lexicomp online drug database, comprehensive geriatric assessment, elderly cancer patients, polypharmacy, cancer treatment
journal title
JOURNAL OF ANALYTICAL ONCOLOGY
J. Anal. Oncol.
volume
1
issue
1
pages
32 - 41
ISSN
1927-7210
language
English
UGent publication?
yes
classification
A2
copyright statement
I have transferred the copyright for this publication to the publisher
id
3025543
handle
http://hdl.handle.net/1854/LU-3025543
date created
2012-10-12 09:22:06
date last changed
2012-10-16 15:43:44
@article{3025543,
  abstract     = {Background: we studied the use of Lexicomp, an online drug information database, for adequate identification of drug-drug interactions within comprehensive geriatric assessment in cancer patients.
Materials and Methods: data of 149 onco-geriatric patients were reviewed. Sixty-tree percent participated in an observational study recruiting head and neck cancer patients, 37\% in a registry recruiting general oncology patients. Baseline drug information was collected by a health professional, through the medical interview within CGA. Drug class usage was quantified and potentional DDIs were assessed and categorized with Lexicomp.
Results: on average, H\&H and GO-patients took 5 and 8 prescription drugs at presentation, respectively. An average of 4 drugs were added in both groups as part of their proposed therapy. Potential DDIs were detected by Lexicomp in 64.9\% and 83.6\% of H\&H and GO patients, respectively, at therapy start. Administration of cancer-therapy-related drugs lead to additional DDIs in 73.7\% and 58.3\% of H\&H and GO cases, respectively. DDIs occured mainly with supportive drugs. Sixteen percent of potential DDIs were identified with anti-neoplastic drugs in the GO-group. Iin 28.7\% and 60.0\% of H\&H and GO patients, respectively, at least one drug was recognized by Lexicomp.
Conclusions: use of Lexicomp drug database within CGA is feasible. It could reduce the administration of inappropiate drugs, and in that way improve the quality of patient-individualized therapie.},
  author       = {Pottel, Lies  and Lycke , Michelle and Boterberg, Tom and Ketelaars, Lore and Pottel, Hans and Goethals, Laurence  and Van Den Noortgate, Nele and DUPREZ, FREDERIC and De Neve, Wilfried and Rottey, Sylvie and Geldhof, Kurt and Van Eygen, Koen  and Kargar-Samani, Khalil and Ghekiere, V{\'e}ronique and Verhaeghe, Anne  and Debruyne, Philip},
  issn         = {1927-7210},
  journal      = {JOURNAL OF ANALYTICAL ONCOLOGY},
  keyword      = {drug-drug interactions,safe prescription behavior,lexicomp online drug database,comprehensive geriatric assessment,elderly cancer patients,polypharmacy,cancer treatment},
  language     = {eng},
  number       = {1},
  pages        = {32--41},
  title        = {Experience with Lexicomp{\textregistered} Online Drug Database for medication review and drug-drug interaction analysis within a comprehensive geriatric assessment in elderly cancer patients},
  volume       = {1},
  year         = {2012},
}

Chicago
Pottel, Lies , Michelle Lycke , Tom Boterberg, Lore Ketelaars, Hans Pottel, Laurence Goethals, Nele Van Den Noortgate, et al. 2012. “Experience with Lexicomp® Online Drug Database for Medication Review and Drug-drug Interaction Analysis Within a Comprehensive Geriatric Assessment in Elderly Cancer Patients.” Journal of Analytical Oncology 1 (1): 32–41.
APA
Pottel, L., Lycke , M., Boterberg, T., Ketelaars, L., Pottel, H., Goethals, L., Van Den Noortgate, N., et al. (2012). Experience with Lexicomp® Online Drug Database for medication review and drug-drug interaction analysis within a comprehensive geriatric assessment in elderly cancer patients. JOURNAL OF ANALYTICAL ONCOLOGY, 1(1), 32–41.
Vancouver
1.
Pottel L, Lycke M, Boterberg T, Ketelaars L, Pottel H, Goethals L, et al. Experience with Lexicomp® Online Drug Database for medication review and drug-drug interaction analysis within a comprehensive geriatric assessment in elderly cancer patients. JOURNAL OF ANALYTICAL ONCOLOGY. 2012;1(1):32–41.
MLA
Pottel, Lies , Michelle Lycke , Tom Boterberg, et al. “Experience with Lexicomp® Online Drug Database for Medication Review and Drug-drug Interaction Analysis Within a Comprehensive Geriatric Assessment in Elderly Cancer Patients.” JOURNAL OF ANALYTICAL ONCOLOGY 1.1 (2012): 32–41. Print.