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Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration

Tuan HN Nguyen, Mathieu Bertrand UGent, Christiane Sterpin, Younes Achouri and Olivier RY De Backer (2010) BMC CELL BIOLOGY. 11.
abstract
Background: In normal adult skeletal muscle, cell turnover is very slow. However, after an acute lesion or in chronic pathological conditions, such as primary myopathies, muscle stem cells, called satellite cells, are induced to proliferate, then withdraw definitively from the cell cycle and fuse to reconstitute functional myofibers. Results: We show that Maged1 is expressed at very low levels in normal adult muscle but is strongly induced after injury, during the early phase of myoblast differentiation. By comparing in vitro differentiation of myoblasts derived from wild-type or Maged1 knockout mice, we observed that Maged1 deficiency results in reduced levels of p21(CIP1/WAF1), defective cell cycle exit and impaired myotube maturation. In vivo, this defect results in delayed regeneration of injured muscle. Conclusions: These data demonstrate for the first time that Maged1 is an important factor required for proper skeletal myoblast differentiation and muscle healing.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CELL-CYCLE ARREST, GENE-EXPRESSION, DNA-BINDING, RETINOBLASTOMA PROTEIN, NEUROTROPHIN RECEPTOR, NECDIN INTERACTS, CDK INHIBITORS, FAMILY PROTEIN, IN-VIVO, MYOD
journal title
BMC CELL BIOLOGY
BMC Cell Biol.
volume
11
article_number
57
pages
9 pages
Web of Science type
Article
Web of Science id
000282732700001
JCR category
CELL BIOLOGY
JCR impact factor
2.464 (2010)
JCR rank
113/174 (2010)
JCR quartile
3 (2010)
ISSN
1471-2121
DOI
10.1186/1471-2121-11-57
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
3025286
handle
http://hdl.handle.net/1854/LU-3025286
date created
2012-10-11 15:53:46
date last changed
2012-10-12 13:15:12
@article{3025286,
  abstract     = {Background: In normal adult skeletal muscle, cell turnover is very slow. However, after an acute lesion or in chronic pathological conditions, such as primary myopathies, muscle stem cells, called satellite cells, are induced to proliferate, then withdraw definitively from the cell cycle and fuse to reconstitute functional myofibers.
Results: We show that Maged1 is expressed at very low levels in normal adult muscle but is strongly induced after injury, during the early phase of myoblast differentiation. By comparing in vitro differentiation of myoblasts derived from wild-type or Maged1 knockout mice, we observed that Maged1 deficiency results in reduced levels of p21(CIP1/WAF1), defective cell cycle exit and impaired myotube maturation. In vivo, this defect results in delayed regeneration of injured muscle.
Conclusions: These data demonstrate for the first time that Maged1 is an important factor required for proper skeletal myoblast differentiation and muscle healing.},
  articleno    = {57},
  author       = {Nguyen, Tuan HN and Bertrand, Mathieu and Sterpin, Christiane and Achouri, Younes and De Backer, Olivier RY},
  issn         = {1471-2121},
  journal      = {BMC CELL BIOLOGY},
  keyword      = {CELL-CYCLE ARREST,GENE-EXPRESSION,DNA-BINDING,RETINOBLASTOMA PROTEIN,NEUROTROPHIN RECEPTOR,NECDIN INTERACTS,CDK INHIBITORS,FAMILY PROTEIN,IN-VIVO,MYOD},
  language     = {eng},
  pages        = {9},
  title        = {Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration},
  url          = {http://dx.doi.org/10.1186/1471-2121-11-57},
  volume       = {11},
  year         = {2010},
}

Chicago
Nguyen, Tuan HN, Mathieu Bertrand, Christiane Sterpin, Younes Achouri, and Olivier RY De Backer. 2010. “Maged1, a New Regulator of Skeletal Myogenic Differentiation and Muscle Regeneration.” Bmc Cell Biology 11.
APA
Nguyen, T. H., Bertrand, M., Sterpin, C., Achouri, Y., & De Backer, O. R. (2010). Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration. BMC CELL BIOLOGY, 11.
Vancouver
1.
Nguyen TH, Bertrand M, Sterpin C, Achouri Y, De Backer OR. Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration. BMC CELL BIOLOGY. 2010;11.
MLA
Nguyen, Tuan HN, Mathieu Bertrand, Christiane Sterpin, et al. “Maged1, a New Regulator of Skeletal Myogenic Differentiation and Muscle Regeneration.” BMC CELL BIOLOGY 11 (2010): n. pag. Print.