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Recommendations for the treatment of epilepsy in adult patients in general practice in Belgium : an update

(2012) ACTA NEUROLOGICA BELGICA. 112(2). p.119-131
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Abstract
In 2008, a group of Belgian epilepsy experts published recommendations for antiepileptic drug (AED) treatment of epilepsies in adults and children. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence for efficacy, common daily practice and the personal views and experiences of the authors. In November 2011 the validity of these recommendations was reviewed by the same group of Belgian epilepsy experts who contributed to the preparation of the original paper. The recommendations made in 2008 for initial monotherapy in paediatric patients were still considered to be valid, except for the first choice treatment for childhood absence epilepsy. This update therefore focuses on the treatment recommendations for initial monotherapy and add-on treatment in adult patients. Several other relevant aspects of treatment with AEDs are addressed, including considerations for optimal combination of AEDs (rational polytherapy), pharmacokinetic properties, pharmacodynamic and pharmacokinetic interaction profile, adverse effects, comorbidity, treatment of elderly patients, AED treatment during pregnancy, and generic substitution of AEDs.
Keywords
Epilepsy, Antiepileptic drugs, Seizures, Treatment, Recommendations, TECHNOLOGY-ASSESSMENT SUBCOMMITTEE, QUALITY STANDARDS SUBCOMMITTEE, ANTIEPILEPTIC DRUGS, ELDERLY-PATIENTS, POSTSTROKE SEIZURES, MANAGEMENT ISSUES, AMERICAN ACADEMY, ILAE COMMISSION, ONSET EPILEPSY, LEVETIRACETAM

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Chicago
Boon, Paul, Sebastiaan Engelborghs, Henri Hauman, An Jansen, Lieven Lagae, Benjamin Legros, Michel Ossemann, et al. 2012. “Recommendations for the Treatment of Epilepsy in Adult Patients in General Practice in Belgium : an Update.” Acta Neurologica Belgica 112 (2): 119–131.
APA
Boon, Paul, Engelborghs, S., Hauman, H., Jansen, A., Lagae, L., Legros, B., Ossemann, M., et al. (2012). Recommendations for the treatment of epilepsy in adult patients in general practice in Belgium : an update. ACTA NEUROLOGICA BELGICA, 112(2), 119–131.
Vancouver
1.
Boon P, Engelborghs S, Hauman H, Jansen A, Lagae L, Legros B, et al. Recommendations for the treatment of epilepsy in adult patients in general practice in Belgium : an update. ACTA NEUROLOGICA BELGICA. 2012;112(2):119–31.
MLA
Boon, Paul, Sebastiaan Engelborghs, Henri Hauman, et al. “Recommendations for the Treatment of Epilepsy in Adult Patients in General Practice in Belgium : an Update.” ACTA NEUROLOGICA BELGICA 112.2 (2012): 119–131. Print.
@article{3025010,
  abstract     = {In 2008, a group of Belgian epilepsy experts published recommendations for antiepileptic drug (AED) treatment of epilepsies in adults and children. Selection of compounds was based on the registration and reimbursement status in Belgium, the level of evidence for efficacy, common daily practice and the personal views and experiences of the authors. In November 2011 the validity of these recommendations was reviewed by the same group of Belgian epilepsy experts who contributed to the preparation of the original paper. The recommendations made in 2008 for initial monotherapy in paediatric patients were still considered to be valid, except for the first choice treatment for childhood absence epilepsy. This update therefore focuses on the treatment recommendations for initial monotherapy and add-on treatment in adult patients. Several other relevant aspects of treatment with AEDs are addressed, including considerations for optimal combination of AEDs (rational polytherapy), pharmacokinetic properties, pharmacodynamic and pharmacokinetic interaction profile, adverse effects, comorbidity, treatment of elderly patients, AED treatment during pregnancy, and generic substitution of AEDs.},
  author       = {Boon, Paul and Engelborghs, Sebastiaan and Hauman, Henri and Jansen, An and Lagae, Lieven and Legros, Benjamin and Ossemann, Michel and Sadzot, Bernard and Smets, Katrien and Urbain, Etienne and van Rijckevorsel, Kenou},
  issn         = {0300-9009},
  journal      = {ACTA NEUROLOGICA BELGICA},
  keyword      = {Epilepsy,Antiepileptic drugs,Seizures,Treatment,Recommendations,TECHNOLOGY-ASSESSMENT SUBCOMMITTEE,QUALITY STANDARDS SUBCOMMITTEE,ANTIEPILEPTIC DRUGS,ELDERLY-PATIENTS,POSTSTROKE SEIZURES,MANAGEMENT ISSUES,AMERICAN ACADEMY,ILAE COMMISSION,ONSET EPILEPSY,LEVETIRACETAM},
  language     = {eng},
  number       = {2},
  pages        = {119--131},
  title        = {Recommendations for the treatment of epilepsy in adult patients in general practice in Belgium : an update},
  url          = {http://dx.doi.org/10.1007/s13760-012-0070-9},
  volume       = {112},
  year         = {2012},
}

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