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Chronic rhinosinusitis: from one disease to different phenotypes

Claus Bachert UGent, Nan Zhang UGent, Thibaut Van Zele UGent and Philippe Gevaert UGent (2012) PEDIATRIC ALLERGY AND IMMUNOLOGY. 23(suppl. 22). p.2-4
abstract
Chronic rhinosinusitis (CRS) has now been discovered as a frequent disease affecting about 11% of the European population. In clinical terms, CRS may be differentiated in two phenotypes, CRS with and without nasal polyps. This differentiation is also confirmed by immunohistochemical studies on the remodeling pattern of those diseases, identifying TGF-beta as the key regulator. Further differentiation may be based on the inflammatory patterns, differentiating endotypes based on prominent T helper cell cytokines such as interleukin-5 and the presence of IgE antibodies against Staphylococcus aureus enterotoxins. The importance of those endotypes has been confirmed by innovative studies using humanized antibodies applied to nasal polyp disease, and by their predictive value for asthma comorbidity. Biomarkers may thus be needed to fully appreciate the CRS disease spectrum and its link to asthma.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
IgE, IL-5, NASAL POLYPS, IGE ANTIBODIES, ASTHMA, ASSOCIATION, RHINITIS, ALLERGEN, GA(2)LEN, EUROPE, nasal polyps, Chronic rhinosinusitis, TGF-ss
journal title
PEDIATRIC ALLERGY AND IMMUNOLOGY
Pediatr. Allergy Immunol.
volume
23
issue
suppl. 22
issue title
Otorhinosinusology issues in pediatric age : from functional anatomy and pathophysiology to diagnosis and treatment
pages
2 - 4
Web of Science type
Review
Web of Science id
000306001800002
JCR category
PEDIATRICS
JCR impact factor
3.376 (2012)
JCR rank
9/119 (2012)
JCR quartile
1 (2012)
ISSN
0905-6157
DOI
10.1111/j.1399-3038.2012.01318.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3023329
handle
http://hdl.handle.net/1854/LU-3023329
date created
2012-10-11 12:22:00
date last changed
2012-10-12 14:24:31
@article{3023329,
  abstract     = {Chronic rhinosinusitis (CRS) has now been discovered as a frequent disease affecting about 11\% of the European population. In clinical terms, CRS may be differentiated in two phenotypes, CRS with and without nasal polyps. This differentiation is also confirmed by immunohistochemical studies on the remodeling pattern of those diseases, identifying TGF-beta as the key regulator. Further differentiation may be based on the inflammatory patterns, differentiating endotypes based on prominent T helper cell cytokines such as interleukin-5 and the presence of IgE antibodies against Staphylococcus aureus enterotoxins. The importance of those endotypes has been confirmed by innovative studies using humanized antibodies applied to nasal polyp disease, and by their predictive value for asthma comorbidity. Biomarkers may thus be needed to fully appreciate the CRS disease spectrum and its link to asthma.},
  author       = {Bachert, Claus and Zhang, Nan and Van Zele, Thibaut and Gevaert, Philippe},
  issn         = {0905-6157},
  journal      = {PEDIATRIC ALLERGY AND IMMUNOLOGY},
  keyword      = {IgE,IL-5,NASAL POLYPS,IGE ANTIBODIES,ASTHMA,ASSOCIATION,RHINITIS,ALLERGEN,GA(2)LEN,EUROPE,nasal polyps,Chronic rhinosinusitis,TGF-ss},
  language     = {eng},
  number       = {suppl. 22},
  pages        = {2--4},
  title        = {Chronic rhinosinusitis: from one disease to different phenotypes},
  url          = {http://dx.doi.org/10.1111/j.1399-3038.2012.01318.x},
  volume       = {23},
  year         = {2012},
}

Chicago
Bachert, Claus, Nan Zhang, Thibaut Van Zele, and Philippe Gevaert. 2012. “Chronic Rhinosinusitis: From One Disease to Different Phenotypes.” Pediatric Allergy and Immunology 23 (suppl. 22): 2–4.
APA
Bachert, C., Zhang, N., Van Zele, T., & Gevaert, P. (2012). Chronic rhinosinusitis: from one disease to different phenotypes. PEDIATRIC ALLERGY AND IMMUNOLOGY, 23(suppl. 22), 2–4.
Vancouver
1.
Bachert C, Zhang N, Van Zele T, Gevaert P. Chronic rhinosinusitis: from one disease to different phenotypes. PEDIATRIC ALLERGY AND IMMUNOLOGY. 2012;23(suppl. 22):2–4.
MLA
Bachert, Claus, Nan Zhang, Thibaut Van Zele, et al. “Chronic Rhinosinusitis: From One Disease to Different Phenotypes.” PEDIATRIC ALLERGY AND IMMUNOLOGY 23.suppl. 22 (2012): 2–4. Print.