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Chronic rhinosinusitis and asthma: novel understanding of the role of IgE 'above atopy'

Claus Bachert UGent and Nan Zhang UGent (2012) JOURNAL OF INTERNAL MEDICINE. 272(2). p.133-143
abstract
Chronic rhinosinusitis (CRS) affects more than 10% of the European population and is often associated with asthma. Phenotypes of CRS can be differentiated based on mucosal remodelling and inflammatory patterns. Understanding the role of central mediators, such as interleukin-5, in these different phenotypes may lead to the development of specific therapeutic approaches. The impact of staphylococcal superantigens has been shown to further modify the immune response, contributing to persistent severe disease via the activation of T and B cells and the formation of local IgE. It is clear that these mechanisms are involved in the systemic spread of upper airway disease with resulting asthma comorbidity, when IgE antibodies to staphylococcal enterotoxins are present at measurable levels in serum. Recent findings point to superantigens as possible causal agents in the intrinsic form of severe asthma, and an anti-IgE strategy has shown promising therapeutic potential in nonatopic patients with nasal polyps and asthma. These findings should lead to a clinically relevant endotyping of patients with upper and lower airway disease and to a new understanding of the role of IgE above atopy.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
chronic rhinosinusitis, nasal polyps, asthma, Staphylococcus aureus, superantigens, T helper cells, AUREUS ENTEROTOXIN-B, NASAL POLYP TISSUE, STAPHYLOCOCCUS-AUREUS, MICROBIAL SUPERANTIGENS, RESEARCH-PROGRAM, SINUS DISEASE, CELLS, INFLAMMATION, ASSOCIATION, BACTERIAL
journal title
JOURNAL OF INTERNAL MEDICINE
J. Intern. Med.
volume
272
issue
2
pages
133 - 143
Web of Science type
Review
Web of Science id
000306895300005
JCR category
MEDICINE, GENERAL & INTERNAL
JCR impact factor
6.455 (2012)
JCR rank
9/149 (2012)
JCR quartile
1 (2012)
ISSN
0954-6820
DOI
10.1111/j.1365-2796.2012.02559.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3023324
handle
http://hdl.handle.net/1854/LU-3023324
date created
2012-10-11 12:19:45
date last changed
2012-10-12 15:04:42
@article{3023324,
  abstract     = {Chronic rhinosinusitis (CRS) affects more than 10\% of the European population and is often associated with asthma. Phenotypes of CRS can be differentiated based on mucosal remodelling and inflammatory patterns. Understanding the role of central mediators, such as interleukin-5, in these different phenotypes may lead to the development of specific therapeutic approaches. The impact of staphylococcal superantigens has been shown to further modify the immune response, contributing to persistent severe disease via the activation of T and B cells and the formation of local IgE. It is clear that these mechanisms are involved in the systemic spread of upper airway disease with resulting asthma comorbidity, when IgE antibodies to staphylococcal enterotoxins are present at measurable levels in serum. Recent findings point to superantigens as possible causal agents in the intrinsic form of severe asthma, and an anti-IgE strategy has shown promising therapeutic potential in nonatopic patients with nasal polyps and asthma. These findings should lead to a clinically relevant endotyping of patients with upper and lower airway disease and to a new understanding of the role of IgE above atopy.},
  author       = {Bachert, Claus and Zhang, Nan},
  issn         = {0954-6820},
  journal      = {JOURNAL OF INTERNAL MEDICINE},
  keyword      = {chronic rhinosinusitis,nasal polyps,asthma,Staphylococcus aureus,superantigens,T helper cells,AUREUS ENTEROTOXIN-B,NASAL POLYP TISSUE,STAPHYLOCOCCUS-AUREUS,MICROBIAL SUPERANTIGENS,RESEARCH-PROGRAM,SINUS DISEASE,CELLS,INFLAMMATION,ASSOCIATION,BACTERIAL},
  language     = {eng},
  number       = {2},
  pages        = {133--143},
  title        = {Chronic rhinosinusitis and asthma: novel understanding of the role of IgE 'above atopy'},
  url          = {http://dx.doi.org/10.1111/j.1365-2796.2012.02559.x},
  volume       = {272},
  year         = {2012},
}

Chicago
Bachert, Claus, and Nan Zhang. 2012. “Chronic Rhinosinusitis and Asthma: Novel Understanding of the Role of IgE ‘Above Atopy’.” Journal of Internal Medicine 272 (2): 133–143.
APA
Bachert, C., & Zhang, N. (2012). Chronic rhinosinusitis and asthma: novel understanding of the role of IgE “above atopy.” JOURNAL OF INTERNAL MEDICINE, 272(2), 133–143.
Vancouver
1.
Bachert C, Zhang N. Chronic rhinosinusitis and asthma: novel understanding of the role of IgE “above atopy.”JOURNAL OF INTERNAL MEDICINE. 2012;272(2):133–43.
MLA
Bachert, Claus, and Nan Zhang. “Chronic Rhinosinusitis and Asthma: Novel Understanding of the Role of IgE ‘Above Atopy’.” JOURNAL OF INTERNAL MEDICINE 272.2 (2012): 133–143. Print.