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Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation

Caroline Borday, Pauline Cabochette, Karine Parain, Nicolas Mazurier, Sylvie Janssens UGent, Hong Tran Thi UGent, Belaid Sekkali, Odile Bronchain, Kris Vleminckx UGent and Morgane Locker, et al. (2012) DEVELOPMENT. 139(19). p.3499-3509
abstract
Continuous neurogenesis in the adult nervous system requires a delicate balance between proliferation and differentiation. Although Wnt/beta-catenin and Hedgehog signalling pathways are thought to share a mitogenic function in adult neural stem/progenitor cells, it remains unclear how they interact in this process. Adult amphibians produce retinal neurons from a pool of neural stem cells localised in the ciliary marginal zone (CMZ). Surprisingly, we found that perturbations of the Wnt and Hedgehog pathways result in opposite proliferative outcomes of neural stem/progenitor cells in the CMZ. Additionally, our study revealed that Wnt and Hedgehog morphogens are produced in mutually exclusive territories of the post-embryonic retina. Using genetic and pharmacological tools, we found that the Wnt and Hedgehog pathways exhibit reciprocal inhibition. Our data suggest that Sfrp-1 and Gli3 contribute to this negative cross-regulation. Altogether, our results reveal an unexpected antagonistic interplay of Wnt and Hedgehog signals that may tightly regulate the extent of neural stem/progenitor cell proliferation in the Xenopus retina.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Retina, Wnt and Hedgehog signalling, Neural stem cells, NEURAL STEM-CELLS, SONIC HEDGEHOG, XENOPUS RETINA, PROGENITOR PROLIFERATION, SUBVENTRICULAR ZONE, INDIAN HEDGEHOG, CILIARY MARGIN, FLOOR PLATE, IN-VIVO, DIFFERENTIATION
journal title
DEVELOPMENT
Development
volume
139
issue
19
pages
3499 - 3509
Web of Science type
Article
Web of Science id
000308391400004
JCR category
DEVELOPMENTAL BIOLOGY
JCR impact factor
6.208 (2012)
JCR rank
5/41 (2012)
JCR quartile
1 (2012)
ISSN
0950-1991
DOI
10.1242/dev.079582
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3022007
handle
http://hdl.handle.net/1854/LU-3022007
date created
2012-10-11 09:19:25
date last changed
2012-10-12 11:53:27
@article{3022007,
  abstract     = {Continuous neurogenesis in the adult nervous system requires a delicate balance between proliferation and differentiation. Although Wnt/beta-catenin and Hedgehog signalling pathways are thought to share a mitogenic function in adult neural stem/progenitor cells, it remains unclear how they interact in this process. Adult amphibians produce retinal neurons from a pool of neural stem cells localised in the ciliary marginal zone (CMZ). Surprisingly, we found that perturbations of the Wnt and Hedgehog pathways result in opposite proliferative outcomes of neural stem/progenitor cells in the CMZ. Additionally, our study revealed that Wnt and Hedgehog morphogens are produced in mutually exclusive territories of the post-embryonic retina. Using genetic and pharmacological tools, we found that the Wnt and Hedgehog pathways exhibit reciprocal inhibition. Our data suggest that Sfrp-1 and Gli3 contribute to this negative cross-regulation. Altogether, our results reveal an unexpected antagonistic interplay of Wnt and Hedgehog signals that may tightly regulate the extent of neural stem/progenitor cell proliferation in the Xenopus retina.},
  author       = {Borday, Caroline and Cabochette, Pauline and Parain, Karine and Mazurier, Nicolas and Janssens, Sylvie and Tran Thi, Hong and Sekkali, Belaid and Bronchain, Odile and Vleminckx, Kris and Locker, Morgane and Perron, Muriel},
  issn         = {0950-1991},
  journal      = {DEVELOPMENT},
  keyword      = {Retina,Wnt and Hedgehog signalling,Neural stem cells,NEURAL STEM-CELLS,SONIC HEDGEHOG,XENOPUS RETINA,PROGENITOR PROLIFERATION,SUBVENTRICULAR ZONE,INDIAN HEDGEHOG,CILIARY MARGIN,FLOOR PLATE,IN-VIVO,DIFFERENTIATION},
  language     = {eng},
  number       = {19},
  pages        = {3499--3509},
  title        = {Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation},
  url          = {http://dx.doi.org/10.1242/dev.079582},
  volume       = {139},
  year         = {2012},
}

Chicago
Borday, Caroline, Pauline Cabochette, Karine Parain, Nicolas Mazurier, Sylvie Janssens, Hong Tran Thi, Belaid Sekkali, et al. 2012. “Antagonistic Cross-regulation Between Wnt and Hedgehog Signalling Pathways Controls Post-embryonic Retinal Proliferation.” Development 139 (19): 3499–3509.
APA
Borday, C., Cabochette, P., Parain, K., Mazurier, N., Janssens, S., Tran Thi, H., Sekkali, B., et al. (2012). Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation. DEVELOPMENT, 139(19), 3499–3509.
Vancouver
1.
Borday C, Cabochette P, Parain K, Mazurier N, Janssens S, Tran Thi H, et al. Antagonistic cross-regulation between Wnt and Hedgehog signalling pathways controls post-embryonic retinal proliferation. DEVELOPMENT. 2012;139(19):3499–509.
MLA
Borday, Caroline, Pauline Cabochette, Karine Parain, et al. “Antagonistic Cross-regulation Between Wnt and Hedgehog Signalling Pathways Controls Post-embryonic Retinal Proliferation.” DEVELOPMENT 139.19 (2012): 3499–3509. Print.