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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Louise V Wain, Germaine C Verwoert, Paul F O'Reilly, Gang Shi, Toby Johnson, Andrew D Johnson, Murielle Bochud, Kenneth M Rice, Peter Henneman, Albert V Smith, et al. (2011) NATURE GENETICS. 43(10). p.1005-1011
abstract
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
RELEVANCE, MICE, GENE, MORTALITY, METAANALYSIS, ADRENERGIC-RECEPTOR TRAFFICKING, HYPERTENSION, HEART-FAILURE, CARDIOVASCULAR-DISEASE RISK, BLOOD-PRESSURE
journal title
NATURE GENETICS
Nature Genet.
volume
43
issue
10
pages
1005 - 1011
Web of Science type
Article
Web of Science id
000295316200017
JCR category
GENETICS & HEREDITY
JCR impact factor
35.532 (2011)
JCR rank
2/155 (2011)
JCR quartile
1 (2011)
ISSN
1061-4036
DOI
10.1038/ng.922
project
Asklepios Study and AortaGen consortium
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3020251
handle
http://hdl.handle.net/1854/LU-3020251
date created
2012-10-10 16:10:27
date last changed
2016-12-19 15:39:45
@article{3020251,
  abstract     = {Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.},
  author       = {Wain, Louise V and Verwoert, Germaine C and O'Reilly, Paul F and Shi, Gang and Johnson, Toby and Johnson, Andrew D and Bochud, Murielle and Rice, Kenneth M and Henneman, Peter and Smith, Albert V and Ehret, Georg B and Amin, Najaf and Larson, Martin G and Mooser, Vincent and Hadley, David and D{\"o}rr, Marcus and Bis, Joshua C and Aspelund, Thor and Esko, T{\~o}nu and Janssens, A Cecile JW and Zhao, Jing Hua and Heath, Simon and Laan, Maris and Fu, Jingyuan and Pistis, Giorgio and Luan, Jian'an and Arora, Pankaj and Lucas, Gavin and Pirastu, Nicola and Pichler, Irene and Jackson, Anne U and Webster, Rebecca J and Zhang, Feng and Peden, John F and Schmidt, Helena and Tanaka, Toshiko and Campbell, Harry and Igl, Wilmar and Milaneschi, Yuri and Hottenga, Jouke-Jan and Vitart, Veronique and Chasman, Daniel I and Trompet, Stella and Bragg-Gresham, Jennifer L and Alizadeh, Behrooz Z and Chambers, John C and Guo, Xiuqing and Lehtim{\"a}ki, Terho and K{\"u}hnel, Brigitte and Lopez, Lorna M and Pola\v{s}ek, Ozren and Boban, Mladen and Nelson, Christopher P and Morrison, Alanna C and Pihur, Vasyl and Ganesh, Santhi K and Hofman, Albert and Kundu, Suman and Mattace-Raso, Francesco US and Rivadeneira, Fernando and Sijbrands, Eric JG and Uitterlinden, Andre G and Hwang, Shih-Jen and Vasan, Ramachandran S and Wang, Thomas J and Bergmann, Sven and Vollenweider, Peter and Waeber, G{\'e}rard and Laitinen, Jaana and Pouta, Anneli and Zitting, Paavo and McArdle, Wendy L and Kroemer, Heyo K and V{\"o}lker, Uwe and V{\"o}lzke, Henry and Glazer, Nicole L and Taylor, Kent D and Harris, Tamara B and Alavere, Helene and Haller, Toomas and Keis, Aime and Tammesoo, Mari-Liis and Aulchenko, Yurii and Barroso, In{\^e}s and Khaw, Kay-Tee and Galan, Pilar and Hercberg, Serge and Lathrop, Mark and Eyheramendy, Susana and Org, Elin and S{\~o}ber, Siim and Lu, Xiaowen and Nolte, Ilja M and Penninx, Brenda W and Corre, Tanguy and Masciullo, Corrado and Sala, Cinzia and Groop, Leif and Voight, Benjamin F and Melander, Olle and O'Donnell, Christopher J and Salomaa, Veikko and d'Adamo, Adamo Pio and Fabretto, Antonella and Faletra, Flavio and Ulivi, Sheila and Del Greco, Fabiola M and Facheris, Maurizio and Collins, Francis S and Bergman, Richard N and Beilby, John P and Hung, Joseph and Musk, A William and Mangino, Massimo and Shin, So-Youn and Soranzo, Nicole and Watkins, Hugh and Goel, Anuj and Hamsten, Anders and Gider, Pierre and Loitfelder, Marisa and Zeginigg, Marion and Hernandez, Dena and Najjar, Samer S and Navarro, Pau and Wild, Sarah H and Corsi, Anna Maria and Singleton, Andrew and de Geus, Eco JC and Willemsen, Gonneke and Parker, Alex N and Rose, Lynda M and Buckley, Brendan and Stott, David and Orru, Marco and Uda, Manuela and van der Klauw, Melanie M and Zhang, Weihua and Li, Xinzhong and Scott, James and Chen, Yii-Der Ida and Burke, Gregory L and K{\"a}h{\"o}nen, Mika and Viikari, Jorma and D{\"o}ring, Angela and Meitinger, Thomas and Davies, Gail and Starr, John M and Emilsson, Valur and Plump, Andrew and Lindeman, Jan H and 't Hoen, Peter AC and K{\"o}nig, Inke R and Felix, Janine F and Clarke, Robert and Hopewell, Jemma C and Ongen, Halit and Breteler, Monique and Debette, St{\'e}phanie and Destefano, Anita L and Fornage, Myriam and Mitchell, Gary F and Smith, Nicholas L and Holm, Hilma and Stefansson, Kari and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Samani, Nilesh J and Preuss, Michael and Rudan, Igor and Hayward, Caroline and Deary, Ian J and Wichmann, H-Erich and Raitakari, Olli T and Palmas, Walter and Kooner, Jaspal S and Stolk, Ronald P and Jukema, J Wouter and Wright, Alan F and Boomsma, Dorret I and Bandinelli, Stefania and Gyllensten, Ulf B and Wilson, James F and Ferrucci, Luigi and Schmidt, Reinhold and Farrall, Martin and Spector, Tim D and Palmer, Lyle J and Tuomilehto, Jaakko and Pfeufer, Arne and Gasparini, Paolo and Siscovick, David and Altshuler, David and Loos, Ruth J and Toniolo, Daniela and Snieder, Harold and Gieger, Christian and Meneton, Pierre and Wareham, Nicholas J and Oostra, Ben A and Metspalu, Andres and Launer, Lenore and Rettig, Rainer and Strachan, David P and Beckmann, Jacques S and Witteman, Jacqueline CM and Erdmann, Jeanette and van Dijk, Ko Willems and Boerwinkle, Eric and Boehnke, Michael and Ridker, Paul M and Jarvelin, Marjo-Riitta and Chakravarti, Aravinda and Abecasis, Goncalo R and Gudnason, Vilmundur and Newton-Cheh, Christopher and Levy, Daniel and Munroe, Patricia B and Psaty, Bruce M and Caulfield, Mark J and Rao, Dabeeru C and Tobin, Martin D and Elliott, Paul and van Duijn, Cornelia M and LifeLines Cohort Study, the and EchoGen Consortium, the and AortaGen Consortium, the and De Bacquer, Dirk and Rietzschel, Ernst and De Backer, Gui and Van Bortel, Lucas and De Buyzere, Marc and Segers, Patrick and Bekaert, Sofie and Gillebert, Thierry and De Meyer, Tim and CHARGE Consortium Heart Failure, the and KidneyGen Consortium, the and CKDGen Consortium, the and Cardiogenics Consortium, the and CardioGram, the},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keyword      = {RELEVANCE,MICE,GENE,MORTALITY,METAANALYSIS,ADRENERGIC-RECEPTOR TRAFFICKING,HYPERTENSION,HEART-FAILURE,CARDIOVASCULAR-DISEASE RISK,BLOOD-PRESSURE},
  language     = {eng},
  number       = {10},
  pages        = {1005--1011},
  title        = {Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure},
  url          = {http://dx.doi.org/10.1038/ng.922},
  volume       = {43},
  year         = {2011},
}

Chicago
Wain, Louise V, Germaine C Verwoert, Paul F O’Reilly, Gang Shi, Toby Johnson, Andrew D Johnson, Murielle Bochud, et al. 2011. “Genome-wide Association Study Identifies Six New Loci Influencing Pulse Pressure and Mean Arterial Pressure.” Nature Genetics 43 (10): 1005–1011.
APA
Wain, L. V., Verwoert, G. C., O’Reilly, P. F., Shi, G., Johnson, T., Johnson, A. D., Bochud, M., et al. (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. NATURE GENETICS, 43(10), 1005–1011.
Vancouver
1.
Wain LV, Verwoert GC, O’Reilly PF, Shi G, Johnson T, Johnson AD, et al. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. NATURE GENETICS. 2011;43(10):1005–11.
MLA
Wain, Louise V, Germaine C Verwoert, Paul F O’Reilly, et al. “Genome-wide Association Study Identifies Six New Loci Influencing Pulse Pressure and Mean Arterial Pressure.” NATURE GENETICS 43.10 (2011): 1005–1011. Print.