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Improving the glycosylation activity of cellobiose/cellodextrin phosphorylase through enzyme engineering

Hai Giang Tran UGent (2012)
abstract
This PhD project is part of a larger project that aims to develop a generic technology for the biocatalytic glycosylation of small molecules. Glycosylation plays a crucial role in many biological processes and can also be used for a variety of industrial applications. Indeed, the attachment of a carbohydrate moiety can significantly improve both the physicochemical and biological properties of small molecules like drugs, cosmetics, fragrances and food ingredients. Unfortunately, only a few biocatalysts are available today that can be used cost-efficiently on an industrial scale. The goal of this research is to explore the use of glycoside phosphorylases for the production of glycosylated compounds. Particular attention will be paid to glycolipid products, which can be used as biosurfactants in a wide range of sectors such as the chemical, cosmetic and detergent industries. Their specific action, low toxicity and biodegradability are the reasons for their popularity as high value microbial products.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
keyword
lactolipid, cellodextrin phosphorylase, cellobiose phosphorylase, loop engineering, glycolipid
pages
196 pages
publisher
Ghent University. Faculty of Bioscience Engineering
place of publication
Ghent, Belgium
defense location
Gent : Faculteit Bio-ingenieurswetenschappen (A0.030)
defense date
2012-10-11 13:30
ISBN
9789059895546
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
3010085
handle
http://hdl.handle.net/1854/LU-3010085
date created
2012-10-09 15:26:28
date last changed
2012-10-10 08:58:51
@phdthesis{3010085,
  abstract     = {This PhD project is part of a larger project that aims to develop a generic technology for the biocatalytic glycosylation of small molecules. Glycosylation plays a crucial role in many biological processes and can also be used for a variety of industrial applications. Indeed, the attachment of a  carbohydrate moiety can significantly improve both the
physicochemical and biological properties of small molecules like drugs, cosmetics, fragrances and food ingredients. Unfortunately, only a few biocatalysts are available today that can be used cost-efficiently on an industrial scale. The goal of this research is to explore the use of glycoside phosphorylases for the production of glycosylated compounds. Particular attention will be paid to glycolipid products, which can be used as biosurfactants in a wide range of sectors such as the chemical, cosmetic and detergent industries. Their specific action, low toxicity and biodegradability are the reasons for their popularity as high value microbial products.},
  author       = {Tran, Hai Giang},
  isbn         = {9789059895546},
  keyword      = {lactolipid,cellodextrin phosphorylase,cellobiose phosphorylase,loop engineering,glycolipid},
  language     = {eng},
  pages        = {196},
  publisher    = {Ghent University. Faculty of Bioscience Engineering},
  school       = {Ghent University},
  title        = {Improving the glycosylation activity of cellobiose/cellodextrin phosphorylase through enzyme engineering},
  year         = {2012},
}

Chicago
Tran, Hai Giang. 2012. “Improving the Glycosylation Activity of Cellobiose/cellodextrin Phosphorylase Through Enzyme Engineering”. Ghent, Belgium: Ghent University. Faculty of Bioscience Engineering.
APA
Tran, H. G. (2012). Improving the glycosylation activity of cellobiose/cellodextrin phosphorylase through enzyme engineering. Ghent University. Faculty of Bioscience Engineering, Ghent, Belgium.
Vancouver
1.
Tran HG. Improving the glycosylation activity of cellobiose/cellodextrin phosphorylase through enzyme engineering. [Ghent, Belgium]: Ghent University. Faculty of Bioscience Engineering; 2012.
MLA
Tran, Hai Giang. “Improving the Glycosylation Activity of Cellobiose/cellodextrin Phosphorylase Through Enzyme Engineering.” 2012 : n. pag. Print.