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Evaluation of the anti-angiogenic activity of saponins from Maesa lanceolata by different assays

Kenn Foubert, Annelies Breynaert, Mart Theunis, Rita Van Den Bossche, Guido RY De Meyer, André Van Daele, Ahmad Faizal UGent, Alain Goossens UGent, Danny Geelen UGent and Edward M Conway, et al. (2012) NATURAL PRODUCT COMMUNICATIONS. 7(9). p.1149-1154
abstract
Angiogenesis, in which a vascular network is established from pre-existing vessels, is a complex multistep process. Mechanisms underlying angiogenesis can be investigated using a variety of in vitro, ex vivo and in vivo approaches. Evaluation of several promising plants and plant metabolites, including terpenoids, revealed promising anti-angiogenic activity. Since the maesasaponins displayed anti-angiogenic activity in the chick chorioallantoic membrane (CAM) assay, their activity was further investigated in several test systems. The rat aorta ring assay was compared with the placental vein assay and then selected for the ex vivo investigation of the saponins. Besides their effect on the viability of HUVEC, the anti-angiogenic capacity of the compounds was also investigated in an in vivo zebrafish assay. The activity of the saponins in the viability assay was more pronounced than in the rat aorta ring assay and similar to the effect observed in the CAM assay. The use of different test systems, however, implies different results in the case of saponins.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Zebrafish assay, Angiogenesis, Saponins, Rat aorta ring assay, HUVEC, Maesa lanceolata, TRITERPENOID SAPONINS, GROWTH-FACTOR, IN-VITRO, VIVO, SODIUM
journal title
NATURAL PRODUCT COMMUNICATIONS
Nat. Prod. Commun.
volume
7
issue
9
pages
1149 - 1154
Web of Science type
Article
Web of Science id
000309319700010
ISSN
1555-9475
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3008743
handle
http://hdl.handle.net/1854/LU-3008743
date created
2012-10-08 14:58:08
date last changed
2013-07-12 11:53:27
@article{3008743,
  abstract     = {Angiogenesis, in which a vascular network is established from pre-existing vessels, is a complex multistep process. Mechanisms underlying angiogenesis can be investigated using a variety of in vitro, ex vivo and in vivo approaches. Evaluation of several promising plants and plant metabolites, including terpenoids, revealed promising anti-angiogenic activity. Since the maesasaponins displayed anti-angiogenic activity in the chick chorioallantoic membrane (CAM) assay, their activity was further investigated in several test systems. The rat aorta ring assay was compared with the placental vein assay and then selected for the ex vivo investigation of the saponins. Besides their effect on the viability of HUVEC, the anti-angiogenic capacity of the compounds was also investigated in an in vivo zebrafish assay. The activity of the saponins in the viability assay was more pronounced than in the rat aorta ring assay and similar to the effect observed in the CAM assay. The use of different test systems, however, implies different results in the case of saponins.},
  author       = {Foubert, Kenn and Breynaert, Annelies and Theunis, Mart and Van Den Bossche, Rita and De Meyer, Guido RY and Van Daele, Andr{\'e} and Faizal, Ahmad and Goossens, Alain and Geelen, Danny and Conway, Edward M and Vlietinck, Arnold and Pieters, Luc and Apers, Sandra},
  issn         = {1555-9475},
  journal      = {NATURAL PRODUCT COMMUNICATIONS},
  keyword      = {Zebrafish assay,Angiogenesis,Saponins,Rat aorta ring assay,HUVEC,Maesa lanceolata,TRITERPENOID SAPONINS,GROWTH-FACTOR,IN-VITRO,VIVO,SODIUM},
  language     = {eng},
  number       = {9},
  pages        = {1149--1154},
  title        = {Evaluation of the anti-angiogenic activity of saponins from Maesa lanceolata by different assays},
  volume       = {7},
  year         = {2012},
}

Chicago
Foubert, Kenn, Annelies Breynaert, Mart Theunis, Rita Van Den Bossche, Guido RY De Meyer, André Van Daele, Ahmad Faizal, et al. 2012. “Evaluation of the Anti-angiogenic Activity of Saponins from Maesa Lanceolata by Different Assays.” Natural Product Communications 7 (9): 1149–1154.
APA
Foubert, Kenn, Breynaert, A., Theunis, M., Van Den Bossche, R., De Meyer, G. R., Van Daele, A., Faizal, A., et al. (2012). Evaluation of the anti-angiogenic activity of saponins from Maesa lanceolata by different assays. NATURAL PRODUCT COMMUNICATIONS, 7(9), 1149–1154.
Vancouver
1.
Foubert K, Breynaert A, Theunis M, Van Den Bossche R, De Meyer GR, Van Daele A, et al. Evaluation of the anti-angiogenic activity of saponins from Maesa lanceolata by different assays. NATURAL PRODUCT COMMUNICATIONS. 2012;7(9):1149–54.
MLA
Foubert, Kenn, Annelies Breynaert, Mart Theunis, et al. “Evaluation of the Anti-angiogenic Activity of Saponins from Maesa Lanceolata by Different Assays.” NATURAL PRODUCT COMMUNICATIONS 7.9 (2012): 1149–1154. Print.