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Evaluation of alkyl polyglucoside as an alternative surfactant in the preparation of peptide-loaded nanoparticles

Ashok Patel UGent, Swati Kulkarni, Tarala D Nandekar and Pradeep R Vavia (2008) JOURNAL OF MICROENCAPSULATION. 25(8). p.531-540
abstract
The present study was carried out to evaluate potentials of alkyl polyglucoside (APG) as an alternative surfactant/stabilizer in the preparation of peptide-loaded nanoparticles. hGF2 (human gel filtration fraction 2) was used as a model peptide and APG based on C10 fatty alcohol (decyl polylglucoside) was used as a representative surfactant. PLA (poly D,L-lactide) and PLGA (poly D,L-lactide-co-glycolide) based nanoparticles were prepared and the effect of APG on particle size, entrapment efficiency and biological activity was evaluated. At a concentration as low as 0.05% w/v, APG provided an excellent stabilization effect, resulting in nanoparticles with better encapsulation efficiency and particle size well below 450 nm. The effective concentration of APG was found to be much less (10-fold) as compared to PVA. Moreover, APG also showed low residual content as compared to PVA. In-vitro and in-vivo biological activity evaluation confirmed that encapsulated peptide was compatible with APG. These preliminary results suggest that APGs can be used as alternate surfactants for nanoparticle preparation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
hGF2, Alkyl polyglucosides, residual surfactant content, ELISA, flow cytometry, SOLVENT EVAPORATION METHOD, POLYVINYL-ALCOHOL, CALLITHRIX-JACCHUS, DELIVERY, MICROENCAPSULATION, NIOSOMES, SIZE
journal title
JOURNAL OF MICROENCAPSULATION
J. Microencapsul.
volume
25
issue
8
pages
531 - 540
Web of Science type
Article
Web of Science id
000260799500002
JCR category
ENGINEERING, CHEMICAL
JCR impact factor
1.314 (2008)
JCR rank
40/116 (2008)
JCR quartile
2 (2008)
ISSN
0265-2048
DOI
10.1080/02652040802075526
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3007971
handle
http://hdl.handle.net/1854/LU-3007971
date created
2012-10-05 23:05:15
date last changed
2012-10-09 16:09:20
@article{3007971,
  abstract     = {The present study was carried out to evaluate potentials of alkyl polyglucoside (APG) as an alternative surfactant/stabilizer in the preparation of peptide-loaded nanoparticles. hGF2 (human gel filtration fraction 2) was used as a model peptide and APG based on C10 fatty alcohol (decyl polylglucoside) was used as a representative surfactant. PLA (poly D,L-lactide) and PLGA (poly D,L-lactide-co-glycolide) based nanoparticles were prepared and the effect of APG on particle size, entrapment efficiency and biological activity was evaluated. At a concentration as low as 0.05\% w/v, APG provided an excellent stabilization effect, resulting in nanoparticles with better encapsulation efficiency and particle size well below 450 nm. The effective concentration of APG was found to be much less (10-fold) as compared to PVA. Moreover, APG also showed low residual content as compared to PVA. In-vitro and in-vivo biological activity evaluation confirmed that encapsulated peptide was compatible with APG. These preliminary results suggest that APGs can be used as alternate surfactants for nanoparticle preparation.},
  author       = {Patel, Ashok and Kulkarni, Swati and Nandekar, Tarala D and Vavia, Pradeep R},
  issn         = {0265-2048},
  journal      = {JOURNAL OF MICROENCAPSULATION},
  keyword      = {hGF2,Alkyl polyglucosides,residual surfactant content,ELISA,flow cytometry,SOLVENT EVAPORATION METHOD,POLYVINYL-ALCOHOL,CALLITHRIX-JACCHUS,DELIVERY,MICROENCAPSULATION,NIOSOMES,SIZE},
  language     = {eng},
  number       = {8},
  pages        = {531--540},
  title        = {Evaluation of alkyl polyglucoside as an alternative surfactant in the preparation of peptide-loaded nanoparticles},
  url          = {http://dx.doi.org/10.1080/02652040802075526},
  volume       = {25},
  year         = {2008},
}

Chicago
Patel, Ashok, Swati Kulkarni, Tarala D Nandekar, and Pradeep R Vavia. 2008. “Evaluation of Alkyl Polyglucoside as an Alternative Surfactant in the Preparation of Peptide-loaded Nanoparticles.” Journal of Microencapsulation 25 (8): 531–540.
APA
Patel, A., Kulkarni, S., Nandekar, T. D., & Vavia, P. R. (2008). Evaluation of alkyl polyglucoside as an alternative surfactant in the preparation of peptide-loaded nanoparticles. JOURNAL OF MICROENCAPSULATION, 25(8), 531–540.
Vancouver
1.
Patel A, Kulkarni S, Nandekar TD, Vavia PR. Evaluation of alkyl polyglucoside as an alternative surfactant in the preparation of peptide-loaded nanoparticles. JOURNAL OF MICROENCAPSULATION. 2008;25(8):531–40.
MLA
Patel, Ashok, Swati Kulkarni, Tarala D Nandekar, et al. “Evaluation of Alkyl Polyglucoside as an Alternative Surfactant in the Preparation of Peptide-loaded Nanoparticles.” JOURNAL OF MICROENCAPSULATION 25.8 (2008): 531–540. Print.