Ghent University Academic Bibliography

Advanced

Preparation and evaluation of taste masked famotidine formulation using drug/β-cyclodextrin/polymer ternary complexation approach

Ashok Patel UGent and Pradeep R Vavia (2008) AAPS PHARMSCITECH. 9(2). p.544-550
abstract
The main aim of the present study was to evaluate potential of ternary complexation (comprising of drug, cyclodextrin and polymer) as an approach for taste masking. For this purpose famotidine with property of bitter taste was selected as a model drug. Improvement in taste masking capability of cyclodextrin towards famotidine was evaluated by formulating a ternary complex including hydrophilic polymer hydroxyl propyl methyl cellulose (HPMC 5 cps) as the third component. Phase solubility analysis at 25 degrees C was carried out for both the binary systems (viz. drug-cyclodextrin and drug-polymer) and the ternary system (drug-cyclodextrin-polymer). Ternary complex was prepared using solution method and was further characterized using XRD, DSC, FT-IR and microscopic studies. In vitro dissolution study was carried out to see the effect of ternary complexation on drug release. Taste perception study was carried out on human volunteers to evaluate the taste masking ability of ternary complexation. Results obtained from phase solubility analysis showed that the combined use of polymer and cyclodextrin effectively increased the stability constant of the complex [from 538 M-1 for binary system to 15,096 M-1 for ternary system]. Ternary system showed effective taste masking as compared to binary complex and at the same time showed no limiting effect on the drug release (D.E-15min=90%). The effective taste masking was attributed to the enhanced complexation of famotidine in ternary system compared to binary system and the same was confirmed from the characterization studies. In conclusion, the study confirmed that ternary complexation can be utilized as an alternative approach for effective taste masking.
Please use this url to cite or link to this publication:
author
organization
alternative title
Preparation and evaluation of taste masked famotidine formulation using drug/beta-cyclodextrin/polymer ternary complexation approach
year
type
journalArticle (original)
publication status
published
subject
keyword
famotidine, cyclodextrin, hydrophillic polymer, stability constant, taste masking, WATER-SOLUBLE POLYMERS, PHARMACEUTICAL APPLICATIONS, BETA-CYCLODEXTRIN, DRUG, SOLUBILIZATION, DELIVERY, FUTURE
journal title
AAPS PHARMSCITECH
AAPS PharmSciTech
volume
9
issue
2
pages
544 - 550
Web of Science type
Article
Web of Science id
000257710000028
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
1.445 (2008)
JCR rank
155/216 (2008)
JCR quartile
3 (2008)
ISSN
1530-9932
DOI
10.1208/s12249-008-9078-0
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
3007968
handle
http://hdl.handle.net/1854/LU-3007968
date created
2012-10-05 23:03:30
date last changed
2012-10-09 15:49:50
@article{3007968,
  abstract     = {The main aim of the present study was to evaluate potential of ternary complexation (comprising of drug, cyclodextrin and polymer) as an approach for taste masking. For this purpose famotidine with property of bitter taste was selected as a model drug. Improvement in taste masking capability of cyclodextrin towards famotidine was evaluated by formulating a ternary complex including hydrophilic polymer hydroxyl propyl methyl cellulose (HPMC 5 cps) as the third component. Phase solubility analysis at 25 degrees C was carried out for both the binary systems (viz. drug-cyclodextrin and drug-polymer) and the ternary system (drug-cyclodextrin-polymer). Ternary complex was prepared using solution method and was further characterized using XRD, DSC, FT-IR and microscopic studies. In vitro dissolution study was carried out to see the effect of ternary complexation on drug release. Taste perception study was carried out on human volunteers to evaluate the taste masking ability of ternary complexation. Results obtained from phase solubility analysis showed that the combined use of polymer and cyclodextrin effectively increased the stability constant of the complex [from 538 M-1 for binary system to 15,096 M-1 for ternary system]. Ternary system showed effective taste masking as compared to binary complex and at the same time showed no limiting effect on the drug release (D.E-15min=90\%). The effective taste masking was attributed to the enhanced complexation of famotidine in ternary system compared to binary system and the same was confirmed from the characterization studies. In conclusion, the study confirmed that ternary complexation can be utilized as an alternative approach for effective taste masking.},
  author       = {Patel, Ashok and Vavia, Pradeep R},
  issn         = {1530-9932},
  journal      = {AAPS PHARMSCITECH},
  keyword      = {famotidine,cyclodextrin,hydrophillic polymer,stability constant,taste masking,WATER-SOLUBLE POLYMERS,PHARMACEUTICAL APPLICATIONS,BETA-CYCLODEXTRIN,DRUG,SOLUBILIZATION,DELIVERY,FUTURE},
  language     = {eng},
  number       = {2},
  pages        = {544--550},
  title        = {Preparation and evaluation of taste masked famotidine formulation using drug/\ensuremath{\beta}-cyclodextrin/polymer ternary complexation approach},
  url          = {http://dx.doi.org/10.1208/s12249-008-9078-0},
  volume       = {9},
  year         = {2008},
}

Chicago
Patel, Ashok, and Pradeep R Vavia. 2008. “Preparation and Evaluation of Taste Masked Famotidine Formulation Using Drug/β-cyclodextrin/polymer Ternary Complexation Approach.” Aaps Pharmscitech 9 (2): 544–550.
APA
Patel, A., & Vavia, P. R. (2008). Preparation and evaluation of taste masked famotidine formulation using drug/β-cyclodextrin/polymer ternary complexation approach. AAPS PHARMSCITECH, 9(2), 544–550.
Vancouver
1.
Patel A, Vavia PR. Preparation and evaluation of taste masked famotidine formulation using drug/β-cyclodextrin/polymer ternary complexation approach. AAPS PHARMSCITECH. 2008;9(2):544–50.
MLA
Patel, Ashok, and Pradeep R Vavia. “Preparation and Evaluation of Taste Masked Famotidine Formulation Using Drug/β-cyclodextrin/polymer Ternary Complexation Approach.” AAPS PHARMSCITECH 9.2 (2008): 544–550. Print.